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Single-value brain activity scores reflect both severity and risk across the Alzheimer's continuum.

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Title: Single-value brain activity scores reflect both severity and risk across the Alzheimer's continuum.
Authors: Soch J; German Center for Neurodegenerative Diseases (DZNE), 37075 Göttingen, Germany.; Bernstein Center for Computational Neuroscience (BCCN), 10117 Berlin, Germany.; Research Group Learning in Early Childhood, Max Planck Institute for Human Cognitive and Brain Sciences (MPI CBS), 04103 Leipzig, Germany., Richter A; Department of Behavioral Neurology, Leibniz Institute for Neurobiology (LIN), 39118 Magdeburg, Germany.; German Center for Mental Health (DZPG), partner site Halle-Jena-Magdeburg, 39120 Magdeburg, Germany.; Center for Intervention and Research on adaptive and maladaptive brain Circuits underlying mental health (C-I-R-C), Halle-Jena-Magdeburg, 39120 Magdeburg, Germany., Kizilirmak JM; German Center for Neurodegenerative Diseases (DZNE), 37075 Göttingen, Germany.; Research Area Educational Careers and Graduate Employment, German Center for Higher Education Research and Science Studies (DZHW), 30159 Hannover, Germany., Schütze H; German Center for Neurodegenerative Diseases (DZNE), 39120 Magdeburg, Germany.; Institute of Cognitive Neurology and Dementia Research (IKND), Otto von Guericke University, 39120 Magdeburg, Germany., Ziegler G; German Center for Neurodegenerative Diseases (DZNE), 39120 Magdeburg, Germany.; Institute of Cognitive Neurology and Dementia Research (IKND), Otto von Guericke University, 39120 Magdeburg, Germany., Altenstein S; German Center for Neurodegenerative Diseases (DZNE), 10117 Berlin, Germany.; Department of Psychiatry and Psychotherapy, Charité-Universitätsmedizin Berlin, corporate member of Freie Universität Berlin, Humboldt-Universität zu Berlin, and Berlin Institute of Health, 10117 Berlin, Germany., Brosseron F; German Center for Neurodegenerative Diseases (DZNE), Bonn, 53127 Bonn, Germany., Dechent P; MR-Research in Neurosciences, Department of Cognitive Neurology, Georg August University, 37075 Göttingen, Germany., Fliessbach K; German Center for Neurodegenerative Diseases (DZNE), Bonn, 53127 Bonn, Germany.; Department of Neurodegenerative Disease and Geriatric Psychiatry, University of Bonn Medical Center, 53127 Bonn, Germany., Freiesleben SD; German Center for Neurodegenerative Diseases (DZNE), 10117 Berlin, Germany.; Department of Psychiatry and Psychotherapy, Charité-Universitätsmedizin Berlin, corporate member of Freie Universität Berlin, Humboldt-Universität zu Berlin, and Berlin Institute of Health, 10117 Berlin, Germany., Glanz W; German Center for Neurodegenerative Diseases (DZNE), 39120 Magdeburg, Germany., Gref D; Department of Psychiatry and Psychotherapy, Charité-Universitätsmedizin Berlin, corporate member of Freie Universität Berlin, Humboldt-Universität zu Berlin, and Berlin Institute of Health, 10117 Berlin, Germany., Heneka MT; Luxembourg Centre for Systems Biomedicine (LCSB), University of Luxembourg, 4367 Belvaux, Luxembourg., Hetzer S; Berlin Center for Advanced Neuroimaging, Charité-Universitätsmedizin Berlin, corporate member of Freie Universität Berlin, Humboldt-Universität zu Berlin, and Berlin Institute of Health, 10117 Berlin, Germany., Incesoy EI; German Center for Neurodegenerative Diseases (DZNE), 39120 Magdeburg, Germany.; Institute of Cognitive Neurology and Dementia Research (IKND), Otto von Guericke University, 39120 Magdeburg, Germany.; Department for Psychiatry and Psychotherapy, University Clinic Magdeburg, 39120 Magdeburg, Germany., Kilimann I; German Center for Neurodegenerative Diseases (DZNE), 18147 Rostock, Germany.; Department of Psychosomatic Medicine, Rostock University Medical Center, 18147 Rostock, Germany., Kimmich O; German Center for Neurodegenerative Diseases (DZNE), Bonn, 53127 Bonn, Germany., Kleineidam L; German Center for Neurodegenerative Diseases (DZNE), Bonn, 53127 Bonn, Germany.; Department of Neurodegenerative Disease and Geriatric Psychiatry, University of Bonn Medical Center, 53127 Bonn, Germany., Kuhn E; German Center for Neurodegenerative Diseases (DZNE), Bonn, 53127 Bonn, Germany., Laske C; German Center for Neurodegenerative Diseases (DZNE), 72076 Tübingen, Germany.; Section for Dementia Research, Hertie Institute for Clinical Brain Research and Department of Psychiatry and Psychotherapy, University of Tübingen, 72076 Tübingen, Germany., Lohse A; Department of Psychiatry and Psychotherapy, Charité-Universitätsmedizin Berlin, corporate member of Freie Universität Berlin, Humboldt-Universität zu Berlin, and Berlin Institute of Health, 10117 Berlin, Germany., Lüsebrink F; German Center for Neurodegenerative Diseases (DZNE), 39120 Magdeburg, Germany., Munk MH; German Center for Neurodegenerative Diseases (DZNE), 72076 Tübingen, Germany.; Department of Psychiatry and Psychotherapy, University of Tübingen, 72076 Tübingen, Germany., Peters O; German Center for Neurodegenerative Diseases (DZNE), 10117 Berlin, Germany.; Department of Psychiatry and Psychotherapy, Charité-Universitätsmedizin Berlin, corporate member of Freie Universität Berlin, Humboldt-Universität zu Berlin, and Berlin Institute of Health, 10117 Berlin, Germany., Preis L; Department of Psychiatry and Psychotherapy, Charité-Universitätsmedizin Berlin, corporate member of Freie Universität Berlin, Humboldt-Universität zu Berlin, and Berlin Institute of Health, 10117 Berlin, Germany., Priller J; German Center for Neurodegenerative Diseases (DZNE), 10117 Berlin, Germany.; Department of Psychiatry and Psychotherapy, Charité-Universitätsmedizin Berlin, corporate member of Freie Universität Berlin, Humboldt-Universität zu Berlin, and Berlin Institute of Health, 10117 Berlin, Germany.; School of Medicine, Department of Psychiatry and Psychotherapy, Technical University of Munich, 81675 Munich, Germany.; Centre for Clinical Brain Sciences, University of Edinburgh and UK DRI, Edinburgh EH16 4SB, UK., Ramirez A; German Center for Neurodegenerative Diseases (DZNE), Bonn, 53127 Bonn, Germany.; Department of Neurodegenerative Disease and Geriatric Psychiatry, University of Bonn Medical Center, 53127 Bonn, Germany.; Excellence Cluster on Cellular Stress Responses in Aging-Associated Diseases (CECAD), University of Cologne, 50931 Köln, Germany.; Division of Neurogenetics and Molecular Psychiatry, Department of Psychiatry and Psychotherapy, Faculty of Medicine and University Hospital Cologne, University of Cologne, 50924 Cologne, Germany.; Department of Psychiatry and Glenn Biggs Institute for Alzheimer's and Neurodegenerative Diseases, UT Health San Antonio, San Antonio, TX 78229, USA., Roeske S; German Center for Neurodegenerative Diseases (DZNE), Bonn, 53127 Bonn, Germany., Rostamzadeh A; Medical Faculty, Department of Psychiatry, University of Cologne, 50924 Cologne, Germany., Roy-Kluth N; German Center for Neurodegenerative Diseases (DZNE), Bonn, 53127 Bonn, Germany., Scheffler K; Department for Biomedical Magnetic Resonance, University of Tübingen, 72076 Tübingen, Germany., Schmid M; German Center for Neurodegenerative Diseases (DZNE), Bonn, 53127 Bonn, Germany.; Institute for Medical Biometry, University Hospital Bonn, 53127 Bonn, Germany., Schneider A; German Center for Neurodegenerative Diseases (DZNE), Bonn, 53127 Bonn, Germany.; Department of Neurodegenerative Disease and Geriatric Psychiatry, University of Bonn Medical Center, 53127 Bonn, Germany., Spottke A; German Center for Neurodegenerative Diseases (DZNE), Bonn, 53127 Bonn, Germany.; Department of Neurology, University of Bonn, 53127 Bonn, Germany., Spruth EJ; German Center for Neurodegenerative Diseases (DZNE), 10117 Berlin, Germany.; Department of Psychiatry and Psychotherapy, Charité-Universitätsmedizin Berlin, corporate member of Freie Universität Berlin, Humboldt-Universität zu Berlin, and Berlin Institute of Health, 10117 Berlin, Germany., Teipel S; German Center for Neurodegenerative Diseases (DZNE), 18147 Rostock, Germany.; Department of Psychosomatic Medicine, Rostock University Medical Center, 18147 Rostock, Germany., Wiltfang J; German Center for Neurodegenerative Diseases (DZNE), 37075 Göttingen, Germany.; Department of Psychiatry and Psychotherapy, University Medical Center, 37075 Göttingen, Germany.; Neurosciences and Signaling Group, Institute of Biomedicine (iBiMED), Department of Medical Sciences, University of Aveiro, 3810-193 Aveiro, Portugal., Jessen F; German Center for Neurodegenerative Diseases (DZNE), Bonn, 53127 Bonn, Germany.; Excellence Cluster on Cellular Stress Responses in Aging-Associated Diseases (CECAD), University of Cologne, 50931 Köln, Germany.; Medical Faculty, Department of Psychiatry, University of Cologne, 50924 Cologne, Germany., Wagner M; German Center for Neurodegenerative Diseases (DZNE), Bonn, 53127 Bonn, Germany.; Department of Neurodegenerative Disease and Geriatric Psychiatry, University of Bonn Medical Center, 53127 Bonn, Germany., Düzel E; German Center for Neurodegenerative Diseases (DZNE), 39120 Magdeburg, Germany.; Institute of Cognitive Neurology and Dementia Research (IKND), Otto von Guericke University, 39120 Magdeburg, Germany.; Center for Behavioral Brain Sciences (CBBS), 39106 Magdeburg, Germany., Schott BH; German Center for Neurodegenerative Diseases (DZNE), 37075 Göttingen, Germany.; Department of Behavioral Neurology, Leibniz Institute for Neurobiology (LIN), 39118 Magdeburg, Germany.; Department of Psychiatry and Psychotherapy, University Medical Center, 37075 Göttingen, Germany.; Center for Behavioral Brain Sciences (CBBS), 39106 Magdeburg, Germany.
Source: Brain : a journal of neurology [Brain] 2024 Nov 04; Vol. 147 (11), pp. 3789-3803.
Publication Type: Journal Article; Multicenter Study
Journal Info: Publisher: Oxford University Press Country of Publication: England NLM ID: 0372537 Publication Model: Print Cited Medium: Internet ISSN: 1460-2156 (Electronic) Linking ISSN: 00068950 NLM ISO Abbreviation: Brain Subsets: MEDLINE
Database: MEDLINE Ultimate
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ISSN:1460-2156
DOI:10.1093/brain/awae149