Extracellular modulation of TREK-2 activity with nanobodies provides insight into the mechanisms of K2P channel regulation.
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| Title: | Extracellular modulation of TREK-2 activity with nanobodies provides insight into the mechanisms of K2P channel regulation. |
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| Authors: | Rödström KEJ; Clarendon Laboratory, Department of Physics, University of Oxford, Oxford, UK.; Kavli Institute for Nanoscience Discovery, University of Oxford, Oxford, UK.; Centre for Medicines Discovery, University of Oxford, Oxford, UK.; Department of Biochemistry, University of Oxford, Oxford, UK., Cloake A; Clarendon Laboratory, Department of Physics, University of Oxford, Oxford, UK., Sörmann J; Clarendon Laboratory, Department of Physics, University of Oxford, Oxford, UK.; Kavli Institute for Nanoscience Discovery, University of Oxford, Oxford, UK., Baronina A; Centre for Medicines Discovery, University of Oxford, Oxford, UK., Smith KHM; Clarendon Laboratory, Department of Physics, University of Oxford, Oxford, UK.; Kavli Institute for Nanoscience Discovery, University of Oxford, Oxford, UK.; Department of Biochemistry, University of Oxford, Oxford, UK., Pike ACW; Centre for Medicines Discovery, University of Oxford, Oxford, UK., Ang J; Centre for Medicines Discovery, University of Oxford, Oxford, UK., Proks P; Clarendon Laboratory, Department of Physics, University of Oxford, Oxford, UK.; Kavli Institute for Nanoscience Discovery, University of Oxford, Oxford, UK., Schewe M; Institute of Physiology, Medical Faculty, Kiel University, Kiel, Germany., Holland-Kaye I; Department of Biochemistry, University of Oxford, Oxford, UK., Bushell SR; Centre for Medicines Discovery, University of Oxford, Oxford, UK., Elliott J; Clarendon Laboratory, Department of Physics, University of Oxford, Oxford, UK., Pardon E; Structural Biology Brussels, Vrije Universiteit Brussel, Brussels, Belgium.; VIB-VUB Center for Structural Biology, VIB, Brussels, Belgium., Baukrowitz T; Institute of Physiology, Medical Faculty, Kiel University, Kiel, Germany., Owens RJ; The Rosalind Franklin Institute, Harwell Campus, Didcot, UK.; Division of Structural Biology, University of Oxford, Oxford, UK., Newstead S; Kavli Institute for Nanoscience Discovery, University of Oxford, Oxford, UK.; Department of Biochemistry, University of Oxford, Oxford, UK.; OXION Initiative in Ion Channels and Disease, University of Oxford, Oxford, UK., Steyaert J; Structural Biology Brussels, Vrije Universiteit Brussel, Brussels, Belgium.; VIB-VUB Center for Structural Biology, VIB, Brussels, Belgium., Carpenter EP; Centre for Medicines Discovery, University of Oxford, Oxford, UK. lizcarpen1@gmail.com.; OXION Initiative in Ion Channels and Disease, University of Oxford, Oxford, UK. lizcarpen1@gmail.com., Tucker SJ; Clarendon Laboratory, Department of Physics, University of Oxford, Oxford, UK. stephen.tucker@physics.ox.ac.uk.; Kavli Institute for Nanoscience Discovery, University of Oxford, Oxford, UK. stephen.tucker@physics.ox.ac.uk.; OXION Initiative in Ion Channels and Disease, University of Oxford, Oxford, UK. stephen.tucker@physics.ox.ac.uk. |
| Source: | Nature communications [Nat Commun] 2024 May 16; Vol. 15 (1), pp. 4173. Date of Electronic Publication: 2024 May 16. |
| Publication Type: | Journal Article |
| Journal Info: | Publisher: Nature Pub. Group Country of Publication: England NLM ID: 101528555 Publication Model: Electronic Cited Medium: Internet ISSN: 2041-1723 (Electronic) Linking ISSN: 20411723 NLM ISO Abbreviation: Nat Commun Subsets: MEDLINE |
| Database: | MEDLINE Ultimate |
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| ISSN: | 2041-1723 |
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| DOI: | 10.1038/s41467-024-48536-2 |
