Gain-of-function mutations of TRPV4 acting in endothelial cells drive blood-CNS barrier breakdown and motor neuron degeneration in mice.
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| Title: | Gain-of-function mutations of TRPV4 acting in endothelial cells drive blood-CNS barrier breakdown and motor neuron degeneration in mice. |
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| Authors: | Sullivan JM; Department of Neurology, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA., Bagnell AM; Department of Neurology, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA., Alevy J; Solomon H. Snyder Department of Neuroscience, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA., Avila EM; George and Anne Ryan Institute for Neuroscience, University of Rhode Island, Kingston, RI 02881, USA.; Department of Biomedical and Pharmaceutical Sciences, College of Pharmacy, University of Rhode Island, Kingston, RI 02881, USA., Mihaljević L; Department of Physiology, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA., Saavedra-Rivera PC; Department of Neurology, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA., Kong L; Department of Neurology, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA., Huh JS; Department of Neurology, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA., McCray BA; Department of Neurology, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA., Aisenberg WH; Department of Neurology, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA., Zuberi AR; Jackson Laboratory, Bar Harbor, ME 04609, USA., Bogdanik L; Jackson Laboratory, Bar Harbor, ME 04609, USA., Lutz CM; Jackson Laboratory, Bar Harbor, ME 04609, USA., Qiu Z; Solomon H. Snyder Department of Neuroscience, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA.; Department of Physiology, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA., Quinlan KA; George and Anne Ryan Institute for Neuroscience, University of Rhode Island, Kingston, RI 02881, USA.; Department of Biomedical and Pharmaceutical Sciences, College of Pharmacy, University of Rhode Island, Kingston, RI 02881, USA., Searson PC; Institute for Nanobiotechnology, Johns Hopkins University, Baltimore, MD 21218, USA.; Department of Biomedical Engineering, Johns Hopkins University, Baltimore, MD 21218, USA.; Department of Materials Science and Engineering, Johns Hopkins University, Baltimore, MD 21218, USA., Sumner CJ; Department of Neurology, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA.; Solomon H. Snyder Department of Neuroscience, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA. |
| Source: | Science translational medicine [Sci Transl Med] 2024 May 22; Vol. 16 (748), pp. eadk1358. Date of Electronic Publication: 2024 May 22. |
| Publication Type: | Journal Article; Research Support, Non-U.S. Gov't; Research Support, N.I.H., Extramural |
| Journal Info: | Publisher: American Association for the Advancement of Science Country of Publication: United States NLM ID: 101505086 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1946-6242 (Electronic) Linking ISSN: 19466234 NLM ISO Abbreviation: Sci Transl Med Subsets: MEDLINE |
| Database: | MEDLINE Ultimate |
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| ISSN: | 1946-6242 |
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| DOI: | 10.1126/scitranslmed.adk1358 |
