A TrkB and TrkC partial agonist restores deficits in synaptic function and promotes activity-dependent synaptic and microglial transcriptomic changes in a late-stage Alzheimer's mouse model.
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| Title: | A TrkB and TrkC partial agonist restores deficits in synaptic function and promotes activity-dependent synaptic and microglial transcriptomic changes in a late-stage Alzheimer's mouse model. |
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| Authors: | Latif-Hernandez A; Department of Neurology & Neurological Sciences, Stanford University School of Medicine, Palo Alto, California, USA., Yang T; Department of Neurology & Neurological Sciences, Stanford University School of Medicine, Palo Alto, California, USA., Butler RR 3rd; Department of Neurology & Neurological Sciences, Stanford University School of Medicine, Palo Alto, California, USA., Losada PM; Department of Neurology & Neurological Sciences, Stanford University School of Medicine, Palo Alto, California, USA.; Wu Tsai Neurosciences Institute, Stanford University, Stanford, California, USA., Minhas PS; Department of Neurology & Neurological Sciences, Stanford University School of Medicine, Palo Alto, California, USA., White H; Department of Neurology & Neurological Sciences, Stanford University School of Medicine, Palo Alto, California, USA., Tran KC; Department of Neurology & Neurological Sciences, Stanford University School of Medicine, Palo Alto, California, USA., Liu H; Department of Neurology & Neurological Sciences, Stanford University School of Medicine, Palo Alto, California, USA., Simmons DA; Department of Neurology & Neurological Sciences, Stanford University School of Medicine, Palo Alto, California, USA., Langness V; Department of Neurology & Neurological Sciences, Stanford University School of Medicine, Palo Alto, California, USA., Andreasson KI; Department of Neurology & Neurological Sciences, Stanford University School of Medicine, Palo Alto, California, USA.; Wu Tsai Neurosciences Institute, Stanford University, Stanford, California, USA.; Chan Zuckerberg Biohub, San Francisco, California, USA., Wyss-Coray T; Department of Neurology & Neurological Sciences, Stanford University School of Medicine, Palo Alto, California, USA.; Wu Tsai Neurosciences Institute, Stanford University, Stanford, California, USA.; The Phil and Penny Knight Initiative for Brain Resilience, Stanford University, Stanford, California, USA., Longo FM; Department of Neurology & Neurological Sciences, Stanford University School of Medicine, Palo Alto, California, USA.; Wu Tsai Neurosciences Institute, Stanford University, Stanford, California, USA. |
| Source: | Alzheimer's & dementia : the journal of the Alzheimer's Association [Alzheimers Dement] 2024 Jul; Vol. 20 (7), pp. 4434-4460. Date of Electronic Publication: 2024 May 23. |
| Publication Type: | Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't |
| Journal Info: | Publisher: John Wiley & Sons, Ltd Country of Publication: United States NLM ID: 101231978 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1552-5279 (Electronic) Linking ISSN: 15525260 NLM ISO Abbreviation: Alzheimers Dement Subsets: MEDLINE |
| Database: | MEDLINE Ultimate |
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| ISSN: | 1552-5279 |
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| DOI: | 10.1002/alz.13857 |
