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A TrkB and TrkC partial agonist restores deficits in synaptic function and promotes activity-dependent synaptic and microglial transcriptomic changes in a late-stage Alzheimer's mouse model.

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Title: A TrkB and TrkC partial agonist restores deficits in synaptic function and promotes activity-dependent synaptic and microglial transcriptomic changes in a late-stage Alzheimer's mouse model.
Authors: Latif-Hernandez A; Department of Neurology & Neurological Sciences, Stanford University School of Medicine, Palo Alto, California, USA., Yang T; Department of Neurology & Neurological Sciences, Stanford University School of Medicine, Palo Alto, California, USA., Butler RR 3rd; Department of Neurology & Neurological Sciences, Stanford University School of Medicine, Palo Alto, California, USA., Losada PM; Department of Neurology & Neurological Sciences, Stanford University School of Medicine, Palo Alto, California, USA.; Wu Tsai Neurosciences Institute, Stanford University, Stanford, California, USA., Minhas PS; Department of Neurology & Neurological Sciences, Stanford University School of Medicine, Palo Alto, California, USA., White H; Department of Neurology & Neurological Sciences, Stanford University School of Medicine, Palo Alto, California, USA., Tran KC; Department of Neurology & Neurological Sciences, Stanford University School of Medicine, Palo Alto, California, USA., Liu H; Department of Neurology & Neurological Sciences, Stanford University School of Medicine, Palo Alto, California, USA., Simmons DA; Department of Neurology & Neurological Sciences, Stanford University School of Medicine, Palo Alto, California, USA., Langness V; Department of Neurology & Neurological Sciences, Stanford University School of Medicine, Palo Alto, California, USA., Andreasson KI; Department of Neurology & Neurological Sciences, Stanford University School of Medicine, Palo Alto, California, USA.; Wu Tsai Neurosciences Institute, Stanford University, Stanford, California, USA.; Chan Zuckerberg Biohub, San Francisco, California, USA., Wyss-Coray T; Department of Neurology & Neurological Sciences, Stanford University School of Medicine, Palo Alto, California, USA.; Wu Tsai Neurosciences Institute, Stanford University, Stanford, California, USA.; The Phil and Penny Knight Initiative for Brain Resilience, Stanford University, Stanford, California, USA., Longo FM; Department of Neurology & Neurological Sciences, Stanford University School of Medicine, Palo Alto, California, USA.; Wu Tsai Neurosciences Institute, Stanford University, Stanford, California, USA.
Source: Alzheimer's & dementia : the journal of the Alzheimer's Association [Alzheimers Dement] 2024 Jul; Vol. 20 (7), pp. 4434-4460. Date of Electronic Publication: 2024 May 23.
Publication Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
Journal Info: Publisher: John Wiley & Sons, Ltd Country of Publication: United States NLM ID: 101231978 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1552-5279 (Electronic) Linking ISSN: 15525260 NLM ISO Abbreviation: Alzheimers Dement Subsets: MEDLINE
Database: MEDLINE Ultimate
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PubType: Academic Journal
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  Data: A TrkB and TrkC partial agonist restores deficits in synaptic function and promotes activity-dependent synaptic and microglial transcriptomic changes in a late-stage Alzheimer's mouse model.
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  Data: <searchLink fieldCode="AU" term="%22Latif-Hernandez+A%22">Latif-Hernandez A</searchLink>; Department of Neurology & Neurological Sciences, Stanford University School of Medicine, Palo Alto, California, USA.<br /><searchLink fieldCode="AU" term="%22Yang+T%22">Yang T</searchLink>; Department of Neurology & Neurological Sciences, Stanford University School of Medicine, Palo Alto, California, USA.<br /><searchLink fieldCode="AU" term="%22Butler+RR+3rd%22">Butler RR 3rd</searchLink>; Department of Neurology & Neurological Sciences, Stanford University School of Medicine, Palo Alto, California, USA.<br /><searchLink fieldCode="AU" term="%22Losada+PM%22">Losada PM</searchLink>; Department of Neurology & Neurological Sciences, Stanford University School of Medicine, Palo Alto, California, USA.; Wu Tsai Neurosciences Institute, Stanford University, Stanford, California, USA.<br /><searchLink fieldCode="AU" term="%22Minhas+PS%22">Minhas PS</searchLink>; Department of Neurology & Neurological Sciences, Stanford University School of Medicine, Palo Alto, California, USA.<br /><searchLink fieldCode="AU" term="%22White+H%22">White H</searchLink>; Department of Neurology & Neurological Sciences, Stanford University School of Medicine, Palo Alto, California, USA.<br /><searchLink fieldCode="AU" term="%22Tran+KC%22">Tran KC</searchLink>; Department of Neurology & Neurological Sciences, Stanford University School of Medicine, Palo Alto, California, USA.<br /><searchLink fieldCode="AU" term="%22Liu+H%22">Liu H</searchLink>; Department of Neurology & Neurological Sciences, Stanford University School of Medicine, Palo Alto, California, USA.<br /><searchLink fieldCode="AU" term="%22Simmons+DA%22">Simmons DA</searchLink>; Department of Neurology & Neurological Sciences, Stanford University School of Medicine, Palo Alto, California, USA.<br /><searchLink fieldCode="AU" term="%22Langness+V%22">Langness V</searchLink>; Department of Neurology & Neurological Sciences, Stanford University School of Medicine, Palo Alto, California, USA.<br /><searchLink fieldCode="AU" term="%22Andreasson+KI%22">Andreasson KI</searchLink>; Department of Neurology & Neurological Sciences, Stanford University School of Medicine, Palo Alto, California, USA.; Wu Tsai Neurosciences Institute, Stanford University, Stanford, California, USA.; Chan Zuckerberg Biohub, San Francisco, California, USA.<br /><searchLink fieldCode="AU" term="%22Wyss-Coray+T%22">Wyss-Coray T</searchLink>; Department of Neurology & Neurological Sciences, Stanford University School of Medicine, Palo Alto, California, USA.; Wu Tsai Neurosciences Institute, Stanford University, Stanford, California, USA.; The Phil and Penny Knight Initiative for Brain Resilience, Stanford University, Stanford, California, USA.<br /><searchLink fieldCode="AU" term="%22Longo+FM%22">Longo FM</searchLink>; Department of Neurology & Neurological Sciences, Stanford University School of Medicine, Palo Alto, California, USA.; Wu Tsai Neurosciences Institute, Stanford University, Stanford, California, USA.
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  Data: <searchLink fieldCode="JN" term="%22101231978%22">Alzheimer's & dementia : the journal of the Alzheimer's Association</searchLink> [Alzheimers Dement] 2024 Jul; Vol. 20 (7), pp. 4434-4460. <i>Date of Electronic Publication: </i>2024 May 23.
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  Data: <i>Publisher: </i><searchLink fieldCode="PB" term="%22John+Wiley+%26+Sons%2C+Ltd%22">John Wiley & Sons, Ltd </searchLink><i>Country of Publication: </i>United States <i>NLM ID: </i>101231978 <i>Publication Model: </i>Print-Electronic <i>Cited Medium: </i>Internet <i>ISSN: </i>1552-5279 (Electronic) <i>Linking ISSN: </i><searchLink fieldCode="IS" term="%2215525260%22">15525260 </searchLink><i>NLM ISO Abbreviation: </i>Alzheimers Dement <i>Subsets: </i>MEDLINE
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        Value: 10.1002/alz.13857
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              Text: 2024 Jul
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