Intratumoral antigen signaling traps CD8+ T cells to confine exhaustion to the tumor site.
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| Title: | Intratumoral antigen signaling traps CD8+ T cells to confine exhaustion to the tumor site. |
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| Authors: | Takahashi M; Medical Research Council Toxicology Unit, University of Cambridge, Gleeson Building, Tennis Court Road, Cambridge CB2 1QR, UK.; Graduate School of Medicine and Faculty of Medicine, University of Tokyo, Tokyo 113-0033, Japan., So TY; Medical Research Council Toxicology Unit, University of Cambridge, Gleeson Building, Tennis Court Road, Cambridge CB2 1QR, UK.; University of Cambridge, CRUK Cambridge Institute, Cambridge CB2 0RE, UK., Chamberlain-Evans V; Medical Research Council Toxicology Unit, University of Cambridge, Gleeson Building, Tennis Court Road, Cambridge CB2 1QR, UK., Hughes R; Medical Research Council Toxicology Unit, University of Cambridge, Gleeson Building, Tennis Court Road, Cambridge CB2 1QR, UK., Yam-Puc JC; Medical Research Council Toxicology Unit, University of Cambridge, Gleeson Building, Tennis Court Road, Cambridge CB2 1QR, UK., Kania K; University of Cambridge, CRUK Cambridge Institute, Cambridge CB2 0RE, UK., Ruhle M; University of Cambridge, CRUK Cambridge Institute, Cambridge CB2 0RE, UK., Mann T; Medical Research Council Toxicology Unit, University of Cambridge, Gleeson Building, Tennis Court Road, Cambridge CB2 1QR, UK., Schuijs MJ; University of Cambridge, CRUK Cambridge Institute, Cambridge CB2 0RE, UK., Coupland P; University of Cambridge, CRUK Cambridge Institute, Cambridge CB2 0RE, UK.; Altos Labs Cambridge Institute, Cambridge CB21 6GP, UK., Naisbitt D; Department of Pharmacology and Therapeutics, University of Liverpool, Sherrington Building, Ashton Street, Liverpool L69 3G, UK., Halim TYF; University of Cambridge, CRUK Cambridge Institute, Cambridge CB2 0RE, UK., Lyons PA; Cambridge Institute of Therapeutic Immunology and Infectious Disease, University of Cambridge, Jeffrey Cheah Biomedical Centre, Cambridge Biomedical Campus, Cambridge, UK.; Department of Medicine, University of Cambridge, School of Clinical Medicine, Cambridge Biomedical Campus, Cambridge, UK., Lio P; Department of Computer Science and Technology, University of Cambridge, Cambridge CB3 0FD, UK., Roychoudhuri R; Department of Pathology, University of Cambridge, Cambridge, UK., Okkenhaug K; Department of Pathology, University of Cambridge, Cambridge, UK., Adams DJ; Experimental Cancer Genetics, Wellcome Sanger Institute, Hinxton, Cambridgeshire CB10 1SA, UK., Smith KGC; Cambridge Institute of Therapeutic Immunology and Infectious Disease, University of Cambridge, Jeffrey Cheah Biomedical Centre, Cambridge Biomedical Campus, Cambridge, UK.; Department of Medicine, University of Cambridge, School of Clinical Medicine, Cambridge Biomedical Campus, Cambridge, UK.; Walter and Eliza Hall Institute of Medical Research, Parkville, VIC 3052, Australia.; University of Melbourne, Parkville, VIC 3052, Australia., Jodrell DI; Department of Oncology, University of Cambridge, School of Clinical Medicine, Cambridge Biomedical Campus, Box 197, Cambridge CB2 0XZ, UK., Chapman MA; Medical Research Council Toxicology Unit, University of Cambridge, Gleeson Building, Tennis Court Road, Cambridge CB2 1QR, UK.; Department of Hematology, University of Cambridge, Cambridge CB2 0RE, UK., Thaventhiran JED; Medical Research Council Toxicology Unit, University of Cambridge, Gleeson Building, Tennis Court Road, Cambridge CB2 1QR, UK.; University of Cambridge, CRUK Cambridge Institute, Cambridge CB2 0RE, UK. |
| Source: | Science immunology [Sci Immunol] 2024 May 24; Vol. 9 (95), pp. eade2094. Date of Electronic Publication: 2024 May 24. |
| Publication Type: | Journal Article; Research Support, Non-U.S. Gov't |
| Journal Info: | Publisher: American Association for the Advancement of Science Country of Publication: United States NLM ID: 101688624 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 2470-9468 (Electronic) Linking ISSN: 24709468 NLM ISO Abbreviation: Sci Immunol Subsets: MEDLINE |
| Database: | MEDLINE Ultimate |
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| ISSN: | 2470-9468 |
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| DOI: | 10.1126/sciimmunol.ade2094 |
