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Intratumoral antigen signaling traps CD8+ T cells to confine exhaustion to the tumor site.

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Title: Intratumoral antigen signaling traps CD8+ T cells to confine exhaustion to the tumor site.
Authors: Takahashi M; Medical Research Council Toxicology Unit, University of Cambridge, Gleeson Building, Tennis Court Road, Cambridge CB2 1QR, UK.; Graduate School of Medicine and Faculty of Medicine, University of Tokyo, Tokyo 113-0033, Japan., So TY; Medical Research Council Toxicology Unit, University of Cambridge, Gleeson Building, Tennis Court Road, Cambridge CB2 1QR, UK.; University of Cambridge, CRUK Cambridge Institute, Cambridge CB2 0RE, UK., Chamberlain-Evans V; Medical Research Council Toxicology Unit, University of Cambridge, Gleeson Building, Tennis Court Road, Cambridge CB2 1QR, UK., Hughes R; Medical Research Council Toxicology Unit, University of Cambridge, Gleeson Building, Tennis Court Road, Cambridge CB2 1QR, UK., Yam-Puc JC; Medical Research Council Toxicology Unit, University of Cambridge, Gleeson Building, Tennis Court Road, Cambridge CB2 1QR, UK., Kania K; University of Cambridge, CRUK Cambridge Institute, Cambridge CB2 0RE, UK., Ruhle M; University of Cambridge, CRUK Cambridge Institute, Cambridge CB2 0RE, UK., Mann T; Medical Research Council Toxicology Unit, University of Cambridge, Gleeson Building, Tennis Court Road, Cambridge CB2 1QR, UK., Schuijs MJ; University of Cambridge, CRUK Cambridge Institute, Cambridge CB2 0RE, UK., Coupland P; University of Cambridge, CRUK Cambridge Institute, Cambridge CB2 0RE, UK.; Altos Labs Cambridge Institute, Cambridge CB21 6GP, UK., Naisbitt D; Department of Pharmacology and Therapeutics, University of Liverpool, Sherrington Building, Ashton Street, Liverpool L69 3G, UK., Halim TYF; University of Cambridge, CRUK Cambridge Institute, Cambridge CB2 0RE, UK., Lyons PA; Cambridge Institute of Therapeutic Immunology and Infectious Disease, University of Cambridge, Jeffrey Cheah Biomedical Centre, Cambridge Biomedical Campus, Cambridge, UK.; Department of Medicine, University of Cambridge, School of Clinical Medicine, Cambridge Biomedical Campus, Cambridge, UK., Lio P; Department of Computer Science and Technology, University of Cambridge, Cambridge CB3 0FD, UK., Roychoudhuri R; Department of Pathology, University of Cambridge, Cambridge, UK., Okkenhaug K; Department of Pathology, University of Cambridge, Cambridge, UK., Adams DJ; Experimental Cancer Genetics, Wellcome Sanger Institute, Hinxton, Cambridgeshire CB10 1SA, UK., Smith KGC; Cambridge Institute of Therapeutic Immunology and Infectious Disease, University of Cambridge, Jeffrey Cheah Biomedical Centre, Cambridge Biomedical Campus, Cambridge, UK.; Department of Medicine, University of Cambridge, School of Clinical Medicine, Cambridge Biomedical Campus, Cambridge, UK.; Walter and Eliza Hall Institute of Medical Research, Parkville, VIC 3052, Australia.; University of Melbourne, Parkville, VIC 3052, Australia., Jodrell DI; Department of Oncology, University of Cambridge, School of Clinical Medicine, Cambridge Biomedical Campus, Box 197, Cambridge CB2 0XZ, UK., Chapman MA; Medical Research Council Toxicology Unit, University of Cambridge, Gleeson Building, Tennis Court Road, Cambridge CB2 1QR, UK.; Department of Hematology, University of Cambridge, Cambridge CB2 0RE, UK., Thaventhiran JED; Medical Research Council Toxicology Unit, University of Cambridge, Gleeson Building, Tennis Court Road, Cambridge CB2 1QR, UK.; University of Cambridge, CRUK Cambridge Institute, Cambridge CB2 0RE, UK.
Source: Science immunology [Sci Immunol] 2024 May 24; Vol. 9 (95), pp. eade2094. Date of Electronic Publication: 2024 May 24.
Publication Type: Journal Article; Research Support, Non-U.S. Gov't
Journal Info: Publisher: American Association for the Advancement of Science Country of Publication: United States NLM ID: 101688624 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 2470-9468 (Electronic) Linking ISSN: 24709468 NLM ISO Abbreviation: Sci Immunol Subsets: MEDLINE
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  Data: Intratumoral antigen signaling traps CD8<superscript>+</superscript> T cells to confine exhaustion to the tumor site.
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  Data: <searchLink fieldCode="AU" term="%22Takahashi+M%22">Takahashi M</searchLink>; Medical Research Council Toxicology Unit, University of Cambridge, Gleeson Building, Tennis Court Road, Cambridge CB2 1QR, UK.; Graduate School of Medicine and Faculty of Medicine, University of Tokyo, Tokyo 113-0033, Japan.<br /><searchLink fieldCode="AU" term="%22So+TY%22">So TY</searchLink>; Medical Research Council Toxicology Unit, University of Cambridge, Gleeson Building, Tennis Court Road, Cambridge CB2 1QR, UK.; University of Cambridge, CRUK Cambridge Institute, Cambridge CB2 0RE, UK.<br /><searchLink fieldCode="AU" term="%22Chamberlain-Evans+V%22">Chamberlain-Evans V</searchLink>; Medical Research Council Toxicology Unit, University of Cambridge, Gleeson Building, Tennis Court Road, Cambridge CB2 1QR, UK.<br /><searchLink fieldCode="AU" term="%22Hughes+R%22">Hughes R</searchLink>; Medical Research Council Toxicology Unit, University of Cambridge, Gleeson Building, Tennis Court Road, Cambridge CB2 1QR, UK.<br /><searchLink fieldCode="AU" term="%22Yam-Puc+JC%22">Yam-Puc JC</searchLink>; Medical Research Council Toxicology Unit, University of Cambridge, Gleeson Building, Tennis Court Road, Cambridge CB2 1QR, UK.<br /><searchLink fieldCode="AU" term="%22Kania+K%22">Kania K</searchLink>; University of Cambridge, CRUK Cambridge Institute, Cambridge CB2 0RE, UK.<br /><searchLink fieldCode="AU" term="%22Ruhle+M%22">Ruhle M</searchLink>; University of Cambridge, CRUK Cambridge Institute, Cambridge CB2 0RE, UK.<br /><searchLink fieldCode="AU" term="%22Mann+T%22">Mann T</searchLink>; Medical Research Council Toxicology Unit, University of Cambridge, Gleeson Building, Tennis Court Road, Cambridge CB2 1QR, UK.<br /><searchLink fieldCode="AU" term="%22Schuijs+MJ%22">Schuijs MJ</searchLink>; University of Cambridge, CRUK Cambridge Institute, Cambridge CB2 0RE, UK.<br /><searchLink fieldCode="AU" term="%22Coupland+P%22">Coupland P</searchLink>; University of Cambridge, CRUK Cambridge Institute, Cambridge CB2 0RE, UK.; Altos Labs Cambridge Institute, Cambridge CB21 6GP, UK.<br /><searchLink fieldCode="AU" term="%22Naisbitt+D%22">Naisbitt D</searchLink>; Department of Pharmacology and Therapeutics, University of Liverpool, Sherrington Building, Ashton Street, Liverpool L69 3G, UK.<br /><searchLink fieldCode="AU" term="%22Halim+TYF%22">Halim TYF</searchLink>; University of Cambridge, CRUK Cambridge Institute, Cambridge CB2 0RE, UK.<br /><searchLink fieldCode="AU" term="%22Lyons+PA%22">Lyons PA</searchLink>; Cambridge Institute of Therapeutic Immunology and Infectious Disease, University of Cambridge, Jeffrey Cheah Biomedical Centre, Cambridge Biomedical Campus, Cambridge, UK.; Department of Medicine, University of Cambridge, School of Clinical Medicine, Cambridge Biomedical Campus, Cambridge, UK.<br /><searchLink fieldCode="AU" term="%22Lio+P%22">Lio P</searchLink>; Department of Computer Science and Technology, University of Cambridge, Cambridge CB3 0FD, UK.<br /><searchLink fieldCode="AU" term="%22Roychoudhuri+R%22">Roychoudhuri R</searchLink>; Department of Pathology, University of Cambridge, Cambridge, UK.<br /><searchLink fieldCode="AU" term="%22Okkenhaug+K%22">Okkenhaug K</searchLink>; Department of Pathology, University of Cambridge, Cambridge, UK.<br /><searchLink fieldCode="AU" term="%22Adams+DJ%22">Adams DJ</searchLink>; Experimental Cancer Genetics, Wellcome Sanger Institute, Hinxton, Cambridgeshire CB10 1SA, UK.<br /><searchLink fieldCode="AU" term="%22Smith+KGC%22">Smith KGC</searchLink>; Cambridge Institute of Therapeutic Immunology and Infectious Disease, University of Cambridge, Jeffrey Cheah Biomedical Centre, Cambridge Biomedical Campus, Cambridge, UK.; Department of Medicine, University of Cambridge, School of Clinical Medicine, Cambridge Biomedical Campus, Cambridge, UK.; Walter and Eliza Hall Institute of Medical Research, Parkville, VIC 3052, Australia.; University of Melbourne, Parkville, VIC 3052, Australia.<br /><searchLink fieldCode="AU" term="%22Jodrell+DI%22">Jodrell DI</searchLink>; Department of Oncology, University of Cambridge, School of Clinical Medicine, Cambridge Biomedical Campus, Box 197, Cambridge CB2 0XZ, UK.<br /><searchLink fieldCode="AU" term="%22Chapman+MA%22">Chapman MA</searchLink>; Medical Research Council Toxicology Unit, University of Cambridge, Gleeson Building, Tennis Court Road, Cambridge CB2 1QR, UK.; Department of Hematology, University of Cambridge, Cambridge CB2 0RE, UK.<br /><searchLink fieldCode="AU" term="%22Thaventhiran+JED%22">Thaventhiran JED</searchLink>; Medical Research Council Toxicology Unit, University of Cambridge, Gleeson Building, Tennis Court Road, Cambridge CB2 1QR, UK.; University of Cambridge, CRUK Cambridge Institute, Cambridge CB2 0RE, UK.
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