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G protein-specific mechanisms in the serotonin 5-HT2A receptor regulate psychosis-related effects and memory deficits.

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Title: G protein-specific mechanisms in the serotonin 5-HT2A receptor regulate psychosis-related effects and memory deficits.
Authors: Kossatz E; Integrative Pharmacology and Systems Neuroscience Research Group, Hospital del Mar Research Institute, Barcelona, Spain., Diez-Alarcia R; Department of Pharmacology, University of the Basque Country/Euskal Herriko Unibertsitatea, Leioa, Bizkaia, Spain.; Centro de Investigación Biomédica en Red de Salud Mental CIBERSAM, Madrid, Spain.; Instituto de Investigación Sanitaria Biobizkaia, Barakaldo, Bizkaia, Spain., Gaitonde SA; Department of Biochemistry and Molecular Medicine, Institute for Research in Immunology and Cancer (IRIC), Université de Montréal, Montréal, Québec, H3T 1J4, Canada., Ramon-Duaso C; Cell-type mechanisms in normal and pathological behaviour Research Group, IMIM-Hospital del Mar Medical Research Institute, Barcelona, Spain., Stepniewski TM; Research Programme on Biomedical Informatics (GRIB), Hospital del Mar Research Institute, Barcelona, Spain.; InterAx Biotech AG, PARK InnovAARE, 5234, Villigen, Switzerland., Aranda-Garcia D; Research Programme on Biomedical Informatics (GRIB), Hospital del Mar Research Institute, Barcelona, Spain.; Department of Medicine and Life Sciences, Pompeu Fabra University, Barcelona, Spain., Muneta-Arrate I; Department of Pharmacology, University of the Basque Country/Euskal Herriko Unibertsitatea, Leioa, Bizkaia, Spain.; Centro de Investigación Biomédica en Red de Salud Mental CIBERSAM, Madrid, Spain., Tepaz E; Department of Biochemistry and Molecular Medicine, Institute for Research in Immunology and Cancer (IRIC), Université de Montréal, Montréal, Québec, H3T 1J4, Canada., Saen-Oon S; NBD NOSTRUM BIODISCOVERY, Av. de Josep Tarradellas, 8-10, 3-2, 08029, Barcelona, Spain., Soliva R; NBD NOSTRUM BIODISCOVERY, Av. de Josep Tarradellas, 8-10, 3-2, 08029, Barcelona, Spain., Shahraki A; Pharmaceutical Chemistry, University of Marburg, Marbacher Weg 8, Marburg, 35037, Germany., Moreira D; Innopharma Drug Screening and Pharmacogenomics Platform. BioFarma research group. Center for Research in Molecular Medicine and Chronic Diseases (CiMUS). Department of Pharmacology, Pharmacy and Pharmaceutical Technology, University of Santiago de Compostela, Santiago de Compostela, Spain.; Health Research Institute of Santiago de Compostela (IDIS), University Hospital of Santiago de Compostela (SERGAS), Trav. Choupana s/n, 15706, Santiago de Compostela, Spain., Brea J; Pharmaceutical Chemistry, University of Marburg, Marbacher Weg 8, Marburg, 35037, Germany.; Innopharma Drug Screening and Pharmacogenomics Platform. BioFarma research group. Center for Research in Molecular Medicine and Chronic Diseases (CiMUS). Department of Pharmacology, Pharmacy and Pharmaceutical Technology, University of Santiago de Compostela, Santiago de Compostela, Spain., Loza MI; Innopharma Drug Screening and Pharmacogenomics Platform. BioFarma research group. Center for Research in Molecular Medicine and Chronic Diseases (CiMUS). Department of Pharmacology, Pharmacy and Pharmaceutical Technology, University of Santiago de Compostela, Santiago de Compostela, Spain.; Health Research Institute of Santiago de Compostela (IDIS), University Hospital of Santiago de Compostela (SERGAS), Trav. Choupana s/n, 15706, Santiago de Compostela, Spain., de la Torre R; Integrative Pharmacology and Systems Neuroscience Research Group, Hospital del Mar Research Institute, Barcelona, Spain., Kolb P; Pharmaceutical Chemistry, University of Marburg, Marbacher Weg 8, Marburg, 35037, Germany., Bouvier M; Department of Biochemistry and Molecular Medicine, Institute for Research in Immunology and Cancer (IRIC), Université de Montréal, Montréal, Québec, H3T 1J4, Canada., Meana JJ; Department of Pharmacology, University of the Basque Country/Euskal Herriko Unibertsitatea, Leioa, Bizkaia, Spain.; Centro de Investigación Biomédica en Red de Salud Mental CIBERSAM, Madrid, Spain.; Instituto de Investigación Sanitaria Biobizkaia, Barakaldo, Bizkaia, Spain., Robledo P; Integrative Pharmacology and Systems Neuroscience Research Group, Hospital del Mar Research Institute, Barcelona, Spain. probledo@imim.es., Selent J; Research Programme on Biomedical Informatics (GRIB), Hospital del Mar Research Institute, Barcelona, Spain. jana.selent@upf.edu.; Department of Medicine and Life Sciences, Pompeu Fabra University, Barcelona, Spain. jana.selent@upf.edu.
Source: Nature communications [Nat Commun] 2024 May 29; Vol. 15 (1), pp. 4307. Date of Electronic Publication: 2024 May 29.
Publication Type: Journal Article
Journal Info: Publisher: Nature Pub. Group Country of Publication: England NLM ID: 101528555 Publication Model: Electronic Cited Medium: Internet ISSN: 2041-1723 (Electronic) Linking ISSN: 20411723 NLM ISO Abbreviation: Nat Commun Subsets: MEDLINE
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  Data: G protein-specific mechanisms in the serotonin 5-HT<subscript>2A</subscript> receptor regulate psychosis-related effects and memory deficits.
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  Data: <searchLink fieldCode="AU" term="%22Kossatz+E%22">Kossatz E</searchLink>; Integrative Pharmacology and Systems Neuroscience Research Group, Hospital del Mar Research Institute, Barcelona, Spain.<br /><searchLink fieldCode="AU" term="%22Diez-Alarcia+R%22">Diez-Alarcia R</searchLink>; Department of Pharmacology, University of the Basque Country/Euskal Herriko Unibertsitatea, Leioa, Bizkaia, Spain.; Centro de Investigación Biomédica en Red de Salud Mental CIBERSAM, Madrid, Spain.; Instituto de Investigación Sanitaria Biobizkaia, Barakaldo, Bizkaia, Spain.<br /><searchLink fieldCode="AU" term="%22Gaitonde+SA%22">Gaitonde SA</searchLink>; Department of Biochemistry and Molecular Medicine, Institute for Research in Immunology and Cancer (IRIC), Université de Montréal, Montréal, Québec, H3T 1J4, Canada.<br /><searchLink fieldCode="AU" term="%22Ramon-Duaso+C%22">Ramon-Duaso C</searchLink>; Cell-type mechanisms in normal and pathological behaviour Research Group, IMIM-Hospital del Mar Medical Research Institute, Barcelona, Spain.<br /><searchLink fieldCode="AU" term="%22Stepniewski+TM%22">Stepniewski TM</searchLink>; Research Programme on Biomedical Informatics (GRIB), Hospital del Mar Research Institute, Barcelona, Spain.; InterAx Biotech AG, PARK InnovAARE, 5234, Villigen, Switzerland.<br /><searchLink fieldCode="AU" term="%22Aranda-Garcia+D%22">Aranda-Garcia D</searchLink>; Research Programme on Biomedical Informatics (GRIB), Hospital del Mar Research Institute, Barcelona, Spain.; Department of Medicine and Life Sciences, Pompeu Fabra University, Barcelona, Spain.<br /><searchLink fieldCode="AU" term="%22Muneta-Arrate+I%22">Muneta-Arrate I</searchLink>; Department of Pharmacology, University of the Basque Country/Euskal Herriko Unibertsitatea, Leioa, Bizkaia, Spain.; Centro de Investigación Biomédica en Red de Salud Mental CIBERSAM, Madrid, Spain.<br /><searchLink fieldCode="AU" term="%22Tepaz+E%22">Tepaz E</searchLink>; Department of Biochemistry and Molecular Medicine, Institute for Research in Immunology and Cancer (IRIC), Université de Montréal, Montréal, Québec, H3T 1J4, Canada.<br /><searchLink fieldCode="AU" term="%22Saen-Oon+S%22">Saen-Oon S</searchLink>; NBD NOSTRUM BIODISCOVERY, Av. de Josep Tarradellas, 8-10, 3-2, 08029, Barcelona, Spain.<br /><searchLink fieldCode="AU" term="%22Soliva+R%22">Soliva R</searchLink>; NBD NOSTRUM BIODISCOVERY, Av. de Josep Tarradellas, 8-10, 3-2, 08029, Barcelona, Spain.<br /><searchLink fieldCode="AU" term="%22Shahraki+A%22">Shahraki A</searchLink>; Pharmaceutical Chemistry, University of Marburg, Marbacher Weg 8, Marburg, 35037, Germany.<br /><searchLink fieldCode="AU" term="%22Moreira+D%22">Moreira D</searchLink>; Innopharma Drug Screening and Pharmacogenomics Platform. BioFarma research group. Center for Research in Molecular Medicine and Chronic Diseases (CiMUS). Department of Pharmacology, Pharmacy and Pharmaceutical Technology, University of Santiago de Compostela, Santiago de Compostela, Spain.; Health Research Institute of Santiago de Compostela (IDIS), University Hospital of Santiago de Compostela (SERGAS), Trav. Choupana s/n, 15706, Santiago de Compostela, Spain.<br /><searchLink fieldCode="AU" term="%22Brea+J%22">Brea J</searchLink>; Pharmaceutical Chemistry, University of Marburg, Marbacher Weg 8, Marburg, 35037, Germany.; Innopharma Drug Screening and Pharmacogenomics Platform. BioFarma research group. Center for Research in Molecular Medicine and Chronic Diseases (CiMUS). Department of Pharmacology, Pharmacy and Pharmaceutical Technology, University of Santiago de Compostela, Santiago de Compostela, Spain.<br /><searchLink fieldCode="AU" term="%22Loza+MI%22">Loza MI</searchLink>; Innopharma Drug Screening and Pharmacogenomics Platform. BioFarma research group. Center for Research in Molecular Medicine and Chronic Diseases (CiMUS). Department of Pharmacology, Pharmacy and Pharmaceutical Technology, University of Santiago de Compostela, Santiago de Compostela, Spain.; Health Research Institute of Santiago de Compostela (IDIS), University Hospital of Santiago de Compostela (SERGAS), Trav. Choupana s/n, 15706, Santiago de Compostela, Spain.<br /><searchLink fieldCode="AU" term="%22de+la+Torre+R%22">de la Torre R</searchLink>; Integrative Pharmacology and Systems Neuroscience Research Group, Hospital del Mar Research Institute, Barcelona, Spain.<br /><searchLink fieldCode="AU" term="%22Kolb+P%22">Kolb P</searchLink>; Pharmaceutical Chemistry, University of Marburg, Marbacher Weg 8, Marburg, 35037, Germany.<br /><searchLink fieldCode="AU" term="%22Bouvier+M%22">Bouvier M</searchLink>; Department of Biochemistry and Molecular Medicine, Institute for Research in Immunology and Cancer (IRIC), Université de Montréal, Montréal, Québec, H3T 1J4, Canada.<br /><searchLink fieldCode="AU" term="%22Meana+JJ%22">Meana JJ</searchLink>; Department of Pharmacology, University of the Basque Country/Euskal Herriko Unibertsitatea, Leioa, Bizkaia, Spain.; Centro de Investigación Biomédica en Red de Salud Mental CIBERSAM, Madrid, Spain.; Instituto de Investigación Sanitaria Biobizkaia, Barakaldo, Bizkaia, Spain.<br /><searchLink fieldCode="AU" term="%22Robledo+P%22">Robledo P</searchLink>; Integrative Pharmacology and Systems Neuroscience Research Group, Hospital del Mar Research Institute, Barcelona, Spain. probledo@imim.es.<br /><searchLink fieldCode="AU" term="%22Selent+J%22">Selent J</searchLink>; Research Programme on Biomedical Informatics (GRIB), Hospital del Mar Research Institute, Barcelona, Spain. jana.selent@upf.edu.; Department of Medicine and Life Sciences, Pompeu Fabra University, Barcelona, Spain. jana.selent@upf.edu.
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