Small molecule induced STING degradation facilitated by the HECT ligase HERC4.
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| Title: | Small molecule induced STING degradation facilitated by the HECT ligase HERC4. |
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| Authors: | Mutlu M; Novartis BioMedical Research, Basel, Switzerland. merve.koch@novartis.com., Schmidt I; Novartis BioMedical Research, Basel, Switzerland., Morrison AI; Novartis BioMedical Research, Basel, Switzerland.; Amsterdam UMC location Vrije Universiteit Amsterdam, Molecular Cell Biology & Immunology, Amsterdam institute for Infection and Immunity, De Boelelaan, 1117, Amsterdam, The Netherlands., Goretzki B; Novartis BioMedical Research, Basel, Switzerland., Freuler F; Novartis BioMedical Research, Basel, Switzerland., Begue D; Novartis BioMedical Research, Basel, Switzerland., Simic O; Novartis BioMedical Research, Basel, Switzerland., Pythoud N; Novartis BioMedical Research, Basel, Switzerland., Ahrne E; Novartis BioMedical Research, Basel, Switzerland., Kapps S; Novartis BioMedical Research, Basel, Switzerland., Roest S; Novartis BioMedical Research, Basel, Switzerland., Bonenfant D; Novartis BioMedical Research, Basel, Switzerland.; Monte Rosa Therapeutics, Basel, Switzerland., Jeanpierre D; Novartis BioMedical Research, Basel, Switzerland., Tran TT; Novartis BioMedical Research, Basel, Switzerland., Maher R; Novartis BioMedical Research, Cambridge, MA, USA., An S; Novartis BioMedical Research, Cambridge, MA, USA., Rietsch A; Novartis BioMedical Research, Basel, Switzerland., Nigsch F; Novartis BioMedical Research, Basel, Switzerland., Hofmann A; Novartis BioMedical Research, Basel, Switzerland., Reece-Hoyes J; Novartis BioMedical Research, Cambridge, MA, USA.; Vector Biology, Cambridge, MA, USA., Parker CN; Novartis BioMedical Research, Basel, Switzerland., Guerini D; Novartis BioMedical Research, Basel, Switzerland. |
| Source: | Nature communications [Nat Commun] 2024 May 29; Vol. 15 (1), pp. 4584. Date of Electronic Publication: 2024 May 29. |
| Publication Type: | Journal Article |
| Journal Info: | Publisher: Nature Pub. Group Country of Publication: England NLM ID: 101528555 Publication Model: Electronic Cited Medium: Internet ISSN: 2041-1723 (Electronic) Linking ISSN: 20411723 NLM ISO Abbreviation: Nat Commun Subsets: MEDLINE |
| Database: | MEDLINE Ultimate |
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| ISSN: | 2041-1723 |
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| DOI: | 10.1038/s41467-024-48922-w |
