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Small molecule induced STING degradation facilitated by the HECT ligase HERC4.

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Title: Small molecule induced STING degradation facilitated by the HECT ligase HERC4.
Authors: Mutlu M; Novartis BioMedical Research, Basel, Switzerland. merve.koch@novartis.com., Schmidt I; Novartis BioMedical Research, Basel, Switzerland., Morrison AI; Novartis BioMedical Research, Basel, Switzerland.; Amsterdam UMC location Vrije Universiteit Amsterdam, Molecular Cell Biology & Immunology, Amsterdam institute for Infection and Immunity, De Boelelaan, 1117, Amsterdam, The Netherlands., Goretzki B; Novartis BioMedical Research, Basel, Switzerland., Freuler F; Novartis BioMedical Research, Basel, Switzerland., Begue D; Novartis BioMedical Research, Basel, Switzerland., Simic O; Novartis BioMedical Research, Basel, Switzerland., Pythoud N; Novartis BioMedical Research, Basel, Switzerland., Ahrne E; Novartis BioMedical Research, Basel, Switzerland., Kapps S; Novartis BioMedical Research, Basel, Switzerland., Roest S; Novartis BioMedical Research, Basel, Switzerland., Bonenfant D; Novartis BioMedical Research, Basel, Switzerland.; Monte Rosa Therapeutics, Basel, Switzerland., Jeanpierre D; Novartis BioMedical Research, Basel, Switzerland., Tran TT; Novartis BioMedical Research, Basel, Switzerland., Maher R; Novartis BioMedical Research, Cambridge, MA, USA., An S; Novartis BioMedical Research, Cambridge, MA, USA., Rietsch A; Novartis BioMedical Research, Basel, Switzerland., Nigsch F; Novartis BioMedical Research, Basel, Switzerland., Hofmann A; Novartis BioMedical Research, Basel, Switzerland., Reece-Hoyes J; Novartis BioMedical Research, Cambridge, MA, USA.; Vector Biology, Cambridge, MA, USA., Parker CN; Novartis BioMedical Research, Basel, Switzerland., Guerini D; Novartis BioMedical Research, Basel, Switzerland.
Source: Nature communications [Nat Commun] 2024 May 29; Vol. 15 (1), pp. 4584. Date of Electronic Publication: 2024 May 29.
Publication Type: Journal Article
Journal Info: Publisher: Nature Pub. Group Country of Publication: England NLM ID: 101528555 Publication Model: Electronic Cited Medium: Internet ISSN: 2041-1723 (Electronic) Linking ISSN: 20411723 NLM ISO Abbreviation: Nat Commun Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: Small molecule induced STING degradation facilitated by the HECT ligase HERC4.
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  Data: <searchLink fieldCode="AU" term="%22Mutlu+M%22">Mutlu M</searchLink>; Novartis BioMedical Research, Basel, Switzerland. merve.koch@novartis.com.<br /><searchLink fieldCode="AU" term="%22Schmidt+I%22">Schmidt I</searchLink>; Novartis BioMedical Research, Basel, Switzerland.<br /><searchLink fieldCode="AU" term="%22Morrison+AI%22">Morrison AI</searchLink>; Novartis BioMedical Research, Basel, Switzerland.; Amsterdam UMC location Vrije Universiteit Amsterdam, Molecular Cell Biology & Immunology, Amsterdam institute for Infection and Immunity, De Boelelaan, 1117, Amsterdam, The Netherlands.<br /><searchLink fieldCode="AU" term="%22Goretzki+B%22">Goretzki B</searchLink>; Novartis BioMedical Research, Basel, Switzerland.<br /><searchLink fieldCode="AU" term="%22Freuler+F%22">Freuler F</searchLink>; Novartis BioMedical Research, Basel, Switzerland.<br /><searchLink fieldCode="AU" term="%22Begue+D%22">Begue D</searchLink>; Novartis BioMedical Research, Basel, Switzerland.<br /><searchLink fieldCode="AU" term="%22Simic+O%22">Simic O</searchLink>; Novartis BioMedical Research, Basel, Switzerland.<br /><searchLink fieldCode="AU" term="%22Pythoud+N%22">Pythoud N</searchLink>; Novartis BioMedical Research, Basel, Switzerland.<br /><searchLink fieldCode="AU" term="%22Ahrne+E%22">Ahrne E</searchLink>; Novartis BioMedical Research, Basel, Switzerland.<br /><searchLink fieldCode="AU" term="%22Kapps+S%22">Kapps S</searchLink>; Novartis BioMedical Research, Basel, Switzerland.<br /><searchLink fieldCode="AU" term="%22Roest+S%22">Roest S</searchLink>; Novartis BioMedical Research, Basel, Switzerland.<br /><searchLink fieldCode="AU" term="%22Bonenfant+D%22">Bonenfant D</searchLink>; Novartis BioMedical Research, Basel, Switzerland.; Monte Rosa Therapeutics, Basel, Switzerland.<br /><searchLink fieldCode="AU" term="%22Jeanpierre+D%22">Jeanpierre D</searchLink>; Novartis BioMedical Research, Basel, Switzerland.<br /><searchLink fieldCode="AU" term="%22Tran+TT%22">Tran TT</searchLink>; Novartis BioMedical Research, Basel, Switzerland.<br /><searchLink fieldCode="AU" term="%22Maher+R%22">Maher R</searchLink>; Novartis BioMedical Research, Cambridge, MA, USA.<br /><searchLink fieldCode="AU" term="%22An+S%22">An S</searchLink>; Novartis BioMedical Research, Cambridge, MA, USA.<br /><searchLink fieldCode="AU" term="%22Rietsch+A%22">Rietsch A</searchLink>; Novartis BioMedical Research, Basel, Switzerland.<br /><searchLink fieldCode="AU" term="%22Nigsch+F%22">Nigsch F</searchLink>; Novartis BioMedical Research, Basel, Switzerland.<br /><searchLink fieldCode="AU" term="%22Hofmann+A%22">Hofmann A</searchLink>; Novartis BioMedical Research, Basel, Switzerland.<br /><searchLink fieldCode="AU" term="%22Reece-Hoyes+J%22">Reece-Hoyes J</searchLink>; Novartis BioMedical Research, Cambridge, MA, USA.; Vector Biology, Cambridge, MA, USA.<br /><searchLink fieldCode="AU" term="%22Parker+CN%22">Parker CN</searchLink>; Novartis BioMedical Research, Basel, Switzerland.<br /><searchLink fieldCode="AU" term="%22Guerini+D%22">Guerini D</searchLink>; Novartis BioMedical Research, Basel, Switzerland.
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  Data: <searchLink fieldCode="JN" term="%22101528555%22">Nature communications</searchLink> [Nat Commun] 2024 May 29; Vol. 15 (1), pp. 4584. <i>Date of Electronic Publication: </i>2024 May 29.
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