TMPRSS2-mediated SARS-CoV-2 uptake boosts innate immune activation, enhances cytopathology, and drives convergent virus evolution.

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Title: TMPRSS2-mediated SARS-CoV-2 uptake boosts innate immune activation, enhances cytopathology, and drives convergent virus evolution.
Authors: Qu B; Division of Veterinary Medicine, Paul-Ehrlich-Institut, 63225 Langen, Germany.; European Virus Bioinformatics Center, 07743 Jena, Germany., Miskey C; Division of Medical Biotechnology, Paul-Ehrlich-Institut, 63225 Langen, Germany., Gömer A; Department of Molecular and Medical Virology, Ruhr University Bochum, 44801 Bochum, Germany., Kleinert RDV; Division of Veterinary Medicine, Paul-Ehrlich-Institut, 63225 Langen, Germany., Ibanez SC; Electron Microscopy of Pathogens, Paul-Ehrlich-Institut, 63225 Langen, Germany., Eberle R; Electron Microscopy of Pathogens, Paul-Ehrlich-Institut, 63225 Langen, Germany., Ebenig A; Division of Veterinary Medicine, Paul-Ehrlich-Institut, 63225 Langen, Germany., Postmus D; Department of Tropical Disease Biology, Liverpool School of Tropical Medicine, Liverpool L3 5QA, United Kingdom.; Institute of Virology, Charité-Universitätsmedizin Berlin, 10117 Berlin, Germany., Nocke MK; Department of Molecular and Medical Virology, Ruhr University Bochum, 44801 Bochum, Germany., Herrmann M; Division of Veterinary Medicine, Paul-Ehrlich-Institut, 63225 Langen, Germany., Itotia TK; Division of Veterinary Medicine, Paul-Ehrlich-Institut, 63225 Langen, Germany.; Department of Physical Sciences, Chuka University, 60400 Chuka, Kenya., Herrmann ST; Department of Molecular and Medical Virology, Ruhr University Bochum, 44801 Bochum, Germany., Heinen N; Department of Molecular and Medical Virology, Ruhr University Bochum, 44801 Bochum, Germany., Höck S; Division of Veterinary Medicine, Paul-Ehrlich-Institut, 63225 Langen, Germany., Hastert FD; Division of Virology, Paul-Ehrlich-Institut, 63225 Langen, Germany., von Rhein C; Division of Virology, Paul-Ehrlich-Institut, 63225 Langen, Germany., Schürmann C; Division of Veterinary Medicine, Paul-Ehrlich-Institut, 63225 Langen, Germany., Li X; Department of Cardiology, Medical University Hospital, 69120 Heidelberg, Germany., van Zandbergen G; Division of Immunology, Paul-Ehrlich-Institut, 63225 Langen, Germany.; Institute for Immunology, University Medical Center of the Johannes Gutenberg University of Mainz, 55131 Mainz, Germany.; Research Center for Immunotherapy, University Medical Center, Johannes Gutenberg-University Mainz, 55131 Mainz, Germany., Widera M; Institute for Medical Virology, University Hospital Frankfurt, Goethe University Frankfurt, 60596 Frankfurt am Main, Germany., Ciesek S; Institute for Medical Virology, University Hospital Frankfurt, Goethe University Frankfurt, 60596 Frankfurt am Main, Germany.; Fraunhofer Institute for Translational Medicine and Pharmacology, 60596 Frankfurt am Main, Germany.; German Center for Infection Research, 38124 Braunschweig, Germany., Schnierle BS; Division of Virology, Paul-Ehrlich-Institut, 63225 Langen, Germany., Tarr AW; School of Life Sciences, Faculty of Medicine and Health Sciences, University of Nottingham, Nottingham NG7 2UH, United Kingdom.; School of Life Sciences and National Institute for Health and Care Research, Nottingham Biomedical Research Centre, University of Nottingham, Nottingham NG7 2UH, United Kingdom., Steinmann E; Department of Molecular and Medical Virology, Ruhr University Bochum, 44801 Bochum, Germany., Goffinet C; Department of Tropical Disease Biology, Liverpool School of Tropical Medicine, Liverpool L3 5QA, United Kingdom.; Institute of Virology, Charité-Universitätsmedizin Berlin, 10117 Berlin, Germany., Pfaender S; Department of Molecular and Medical Virology, Ruhr University Bochum, 44801 Bochum, Germany.; Research Unit Emerging Viruses, Leibniz Institute of Virology, 20251 Hamburg, Germany.; University of Lübeck, 23562 Lübeck, Germany., Locker JK; Electron Microscopy of Pathogens, Paul-Ehrlich-Institut, 63225 Langen, Germany.; Justus Liebig University Geissen, 35390 Giessen, Germany., Mühlebach MD; Division of Veterinary Medicine, Paul-Ehrlich-Institut, 63225 Langen, Germany.; German Center for Infection Research, 63225 Giessen-Marburg-Langen, Germany., Todt D; European Virus Bioinformatics Center, 07743 Jena, Germany.; Department of Molecular and Medical Virology, Ruhr University Bochum, 44801 Bochum, Germany., Brown RJP; Division of Veterinary Medicine, Paul-Ehrlich-Institut, 63225 Langen, Germany.; Department of Molecular and Medical Virology, Ruhr University Bochum, 44801 Bochum, Germany.
Source: Proceedings of the National Academy of Sciences of the United States of America [Proc Natl Acad Sci U S A] 2024 Jun 04; Vol. 121 (23), pp. e2407437121. Date of Electronic Publication: 2024 May 30.
Publication Type: Journal Article
Journal Info: Publisher: National Academy of Sciences Country of Publication: United States NLM ID: 7505876 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1091-6490 (Electronic) Linking ISSN: 00278424 NLM ISO Abbreviation: Proc Natl Acad Sci U S A Subsets: MEDLINE
Database: MEDLINE Ultimate
Description
ISSN:1091-6490
DOI:10.1073/pnas.2407437121