Mediator kinase inhibition impedes transcriptional plasticity and prevents resistance to ERK/MAPK-targeted therapy in KRAS-mutant cancers.
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| Title: | Mediator kinase inhibition impedes transcriptional plasticity and prevents resistance to ERK/MAPK-targeted therapy in KRAS-mutant cancers. |
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| Authors: | Nussbaum DP; Department of Surgery, Duke University School of Medicine, Durham, NC, USA., Martz CA; Department of Pharmacology and Cancer Biology, Duke University School of Medicine, Durham, NC, USA., Waters AM; Department of Pharmacology, University of North Carolina at Chapel Hill, Lineberger Comprehensive Cancer Center, Chapel Hill, NC, USA., Barrera A; Department of Biostatistics and Bioinformatics, Duke University School of Medicine, Durham, NC, USA., Liu A; Department of Surgery, Duke University School of Medicine, Durham, NC, USA., Rutter JC; Department of Pharmacology and Cancer Biology, Duke University School of Medicine, Durham, NC, USA., Cerda-Smith CG; Department of Pharmacology and Cancer Biology, Duke University School of Medicine, Durham, NC, USA., Stewart AE; Department of Pharmacology and Cancer Biology, Duke University School of Medicine, Durham, NC, USA., Wu C; Department of Surgery, Memorial Sloan Kettering Cancer Center, Colorectal Service, New York, NY, USA., Cakir M; Department of Pharmacology and Cancer Biology, Duke University School of Medicine, Durham, NC, USA., Levandowski CB; Department of Biochemistry, University of Colorado Boulder, Boulder, CO, USA., Kantrowitz DE; Department of Pharmacology and Cancer Biology, Duke University School of Medicine, Durham, NC, USA., McCall SJ; Department of Pathology, Duke University School of Medicine, Durham, NC, USA., Pierobon M; George Mason University, Center for Applied Proteomics and Molecular Medicine, Fairfax, VA, USA., Petricoin EF 3rd; George Mason University, Center for Applied Proteomics and Molecular Medicine, Fairfax, VA, USA., Joshua Smith J; Department of Surgery, Memorial Sloan Kettering Cancer Center, Colorectal Service, New York, NY, USA., Reddy TE; Department of Biostatistics and Bioinformatics, Duke University School of Medicine, Durham, NC, USA., Der CJ; Department of Pharmacology, University of North Carolina at Chapel Hill, Lineberger Comprehensive Cancer Center, Chapel Hill, NC, USA., Taatjes DJ; Department of Biochemistry, University of Colorado Boulder, Boulder, CO, USA., Wood KC; Department of Pharmacology and Cancer Biology, Duke University School of Medicine, Durham, NC, USA. kris.wood@duke.edu. |
| Source: | NPJ precision oncology [NPJ Precis Oncol] 2024 May 31; Vol. 8 (1), pp. 124. Date of Electronic Publication: 2024 May 31. |
| Publication Type: | Journal Article |
| Journal Info: | Publisher: Springer Nature Country of Publication: England NLM ID: 101708166 Publication Model: Electronic Cited Medium: Print ISSN: 2397-768X (Print) Linking ISSN: 2397768X NLM ISO Abbreviation: NPJ Precis Oncol Subsets: PubMed not MEDLINE |
| Database: | MEDLINE Ultimate |
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| ISSN: | 2397-768X |
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| DOI: | 10.1038/s41698-024-00615-9 |
