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Mediator kinase inhibition impedes transcriptional plasticity and prevents resistance to ERK/MAPK-targeted therapy in KRAS-mutant cancers.

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Title: Mediator kinase inhibition impedes transcriptional plasticity and prevents resistance to ERK/MAPK-targeted therapy in KRAS-mutant cancers.
Authors: Nussbaum DP; Department of Surgery, Duke University School of Medicine, Durham, NC, USA., Martz CA; Department of Pharmacology and Cancer Biology, Duke University School of Medicine, Durham, NC, USA., Waters AM; Department of Pharmacology, University of North Carolina at Chapel Hill, Lineberger Comprehensive Cancer Center, Chapel Hill, NC, USA., Barrera A; Department of Biostatistics and Bioinformatics, Duke University School of Medicine, Durham, NC, USA., Liu A; Department of Surgery, Duke University School of Medicine, Durham, NC, USA., Rutter JC; Department of Pharmacology and Cancer Biology, Duke University School of Medicine, Durham, NC, USA., Cerda-Smith CG; Department of Pharmacology and Cancer Biology, Duke University School of Medicine, Durham, NC, USA., Stewart AE; Department of Pharmacology and Cancer Biology, Duke University School of Medicine, Durham, NC, USA., Wu C; Department of Surgery, Memorial Sloan Kettering Cancer Center, Colorectal Service, New York, NY, USA., Cakir M; Department of Pharmacology and Cancer Biology, Duke University School of Medicine, Durham, NC, USA., Levandowski CB; Department of Biochemistry, University of Colorado Boulder, Boulder, CO, USA., Kantrowitz DE; Department of Pharmacology and Cancer Biology, Duke University School of Medicine, Durham, NC, USA., McCall SJ; Department of Pathology, Duke University School of Medicine, Durham, NC, USA., Pierobon M; George Mason University, Center for Applied Proteomics and Molecular Medicine, Fairfax, VA, USA., Petricoin EF 3rd; George Mason University, Center for Applied Proteomics and Molecular Medicine, Fairfax, VA, USA., Joshua Smith J; Department of Surgery, Memorial Sloan Kettering Cancer Center, Colorectal Service, New York, NY, USA., Reddy TE; Department of Biostatistics and Bioinformatics, Duke University School of Medicine, Durham, NC, USA., Der CJ; Department of Pharmacology, University of North Carolina at Chapel Hill, Lineberger Comprehensive Cancer Center, Chapel Hill, NC, USA., Taatjes DJ; Department of Biochemistry, University of Colorado Boulder, Boulder, CO, USA., Wood KC; Department of Pharmacology and Cancer Biology, Duke University School of Medicine, Durham, NC, USA. kris.wood@duke.edu.
Source: NPJ precision oncology [NPJ Precis Oncol] 2024 May 31; Vol. 8 (1), pp. 124. Date of Electronic Publication: 2024 May 31.
Publication Type: Journal Article
Journal Info: Publisher: Springer Nature Country of Publication: England NLM ID: 101708166 Publication Model: Electronic Cited Medium: Print ISSN: 2397-768X (Print) Linking ISSN: 2397768X NLM ISO Abbreviation: NPJ Precis Oncol Subsets: PubMed not MEDLINE
Database: MEDLINE Ultimate
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  Data: Mediator kinase inhibition impedes transcriptional plasticity and prevents resistance to ERK/MAPK-targeted therapy in KRAS-mutant cancers.
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  Data: <searchLink fieldCode="AU" term="%22Nussbaum+DP%22">Nussbaum DP</searchLink>; Department of Surgery, Duke University School of Medicine, Durham, NC, USA.<br /><searchLink fieldCode="AU" term="%22Martz+CA%22">Martz CA</searchLink>; Department of Pharmacology and Cancer Biology, Duke University School of Medicine, Durham, NC, USA.<br /><searchLink fieldCode="AU" term="%22Waters+AM%22">Waters AM</searchLink>; Department of Pharmacology, University of North Carolina at Chapel Hill, Lineberger Comprehensive Cancer Center, Chapel Hill, NC, USA.<br /><searchLink fieldCode="AU" term="%22Barrera+A%22">Barrera A</searchLink>; Department of Biostatistics and Bioinformatics, Duke University School of Medicine, Durham, NC, USA.<br /><searchLink fieldCode="AU" term="%22Liu+A%22">Liu A</searchLink>; Department of Surgery, Duke University School of Medicine, Durham, NC, USA.<br /><searchLink fieldCode="AU" term="%22Rutter+JC%22">Rutter JC</searchLink>; Department of Pharmacology and Cancer Biology, Duke University School of Medicine, Durham, NC, USA.<br /><searchLink fieldCode="AU" term="%22Cerda-Smith+CG%22">Cerda-Smith CG</searchLink>; Department of Pharmacology and Cancer Biology, Duke University School of Medicine, Durham, NC, USA.<br /><searchLink fieldCode="AU" term="%22Stewart+AE%22">Stewart AE</searchLink>; Department of Pharmacology and Cancer Biology, Duke University School of Medicine, Durham, NC, USA.<br /><searchLink fieldCode="AU" term="%22Wu+C%22">Wu C</searchLink>; Department of Surgery, Memorial Sloan Kettering Cancer Center, Colorectal Service, New York, NY, USA.<br /><searchLink fieldCode="AU" term="%22Cakir+M%22">Cakir M</searchLink>; Department of Pharmacology and Cancer Biology, Duke University School of Medicine, Durham, NC, USA.<br /><searchLink fieldCode="AU" term="%22Levandowski+CB%22">Levandowski CB</searchLink>; Department of Biochemistry, University of Colorado Boulder, Boulder, CO, USA.<br /><searchLink fieldCode="AU" term="%22Kantrowitz+DE%22">Kantrowitz DE</searchLink>; Department of Pharmacology and Cancer Biology, Duke University School of Medicine, Durham, NC, USA.<br /><searchLink fieldCode="AU" term="%22McCall+SJ%22">McCall SJ</searchLink>; Department of Pathology, Duke University School of Medicine, Durham, NC, USA.<br /><searchLink fieldCode="AU" term="%22Pierobon+M%22">Pierobon M</searchLink>; George Mason University, Center for Applied Proteomics and Molecular Medicine, Fairfax, VA, USA.<br /><searchLink fieldCode="AU" term="%22Petricoin+EF+3rd%22">Petricoin EF 3rd</searchLink>; George Mason University, Center for Applied Proteomics and Molecular Medicine, Fairfax, VA, USA.<br /><searchLink fieldCode="AU" term="%22Joshua+Smith+J%22">Joshua Smith J</searchLink>; Department of Surgery, Memorial Sloan Kettering Cancer Center, Colorectal Service, New York, NY, USA.<br /><searchLink fieldCode="AU" term="%22Reddy+TE%22">Reddy TE</searchLink>; Department of Biostatistics and Bioinformatics, Duke University School of Medicine, Durham, NC, USA.<br /><searchLink fieldCode="AU" term="%22Der+CJ%22">Der CJ</searchLink>; Department of Pharmacology, University of North Carolina at Chapel Hill, Lineberger Comprehensive Cancer Center, Chapel Hill, NC, USA.<br /><searchLink fieldCode="AU" term="%22Taatjes+DJ%22">Taatjes DJ</searchLink>; Department of Biochemistry, University of Colorado Boulder, Boulder, CO, USA.<br /><searchLink fieldCode="AU" term="%22Wood+KC%22">Wood KC</searchLink>; Department of Pharmacology and Cancer Biology, Duke University School of Medicine, Durham, NC, USA. kris.wood@duke.edu.
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  Data: <i>Publisher: </i><searchLink fieldCode="PB" term="%22Springer+Nature%22">Springer Nature </searchLink><i>Country of Publication: </i>England <i>NLM ID: </i>101708166 <i>Publication Model: </i>Electronic <i>Cited Medium: </i>Print <i>ISSN: </i>2397-768X (Print) <i>Linking ISSN: </i><searchLink fieldCode="IS" term="%222397768X%22">2397768X </searchLink><i>NLM ISO Abbreviation: </i>NPJ Precis Oncol <i>Subsets: </i>PubMed not MEDLINE
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