Peripheral expression of brain-penetrant progranulin rescues pathologies in mouse models of frontotemporal lobar degeneration.
Saved in:
| Title: | Peripheral expression of brain-penetrant progranulin rescues pathologies in mouse models of frontotemporal lobar degeneration. |
|---|---|
| Authors: | Reich M; German Center for Neurodegenerative Diseases (DZNE), 81377 Munich, Germany.; Graduate School of Systemic Neurosciences (GSN), LMU Munich, 82152 Planegg, Germany.; Institute for Stroke and Dementia Research (ISD), University Hospital, LMU Munich, 81377 Munich, Germany., Simon MJ; Denali Therapeutics Inc., South San Francisco, CA 94080, USA., Polke B; Metabolic Biochemistry, Biomedical Centre (BMC), Faculty of Medicine, LMU Munich, 81377 Munich, Germany., Paris I; Metabolic Biochemistry, Biomedical Centre (BMC), Faculty of Medicine, LMU Munich, 81377 Munich, Germany., Werner G; Metabolic Biochemistry, Biomedical Centre (BMC), Faculty of Medicine, LMU Munich, 81377 Munich, Germany., Schrader C; Metabolic Biochemistry, Biomedical Centre (BMC), Faculty of Medicine, LMU Munich, 81377 Munich, Germany., Spieth L; German Center for Neurodegenerative Diseases (DZNE), 81377 Munich, Germany.; Institute of Neuronal Cell Biology, Technical University Munich, 80802 Munich, Germany.; Max Planck Institute for Multidisciplinary Sciences, 37077 Göttingen, Germany., Davis SS; Denali Therapeutics Inc., South San Francisco, CA 94080, USA., Robinson S; Graduate School of Systemic Neurosciences (GSN), LMU Munich, 82152 Planegg, Germany.; Institute for Stroke and Dementia Research (ISD), University Hospital, LMU Munich, 81377 Munich, Germany.; Metabolic Biochemistry, Biomedical Centre (BMC), Faculty of Medicine, LMU Munich, 81377 Munich, Germany., de Melo GL; Denali Therapeutics Inc., South San Francisco, CA 94080, USA., Schlaphoff L; German Center for Neurodegenerative Diseases (DZNE), 81377 Munich, Germany.; Graduate School of Systemic Neurosciences (GSN), LMU Munich, 82152 Planegg, Germany.; Institute of Neuronal Cell Biology, Technical University Munich, 80802 Munich, Germany., Buschmann K; Metabolic Biochemistry, Biomedical Centre (BMC), Faculty of Medicine, LMU Munich, 81377 Munich, Germany., Berghoff S; German Center for Neurodegenerative Diseases (DZNE), 81377 Munich, Germany.; Institute of Neuronal Cell Biology, Technical University Munich, 80802 Munich, Germany.; Max Planck Institute for Multidisciplinary Sciences, 37077 Göttingen, Germany., Logan T; Denali Therapeutics Inc., South San Francisco, CA 94080, USA., Nuscher B; Metabolic Biochemistry, Biomedical Centre (BMC), Faculty of Medicine, LMU Munich, 81377 Munich, Germany., de Weerd L; German Center for Neurodegenerative Diseases (DZNE), 81377 Munich, Germany., Edbauer D; German Center for Neurodegenerative Diseases (DZNE), 81377 Munich, Germany.; Munich Cluster for Systems Neurology (Synergy), 81377 Munich, Germany., Simons M; German Center for Neurodegenerative Diseases (DZNE), 81377 Munich, Germany.; Institute for Stroke and Dementia Research (ISD), University Hospital, LMU Munich, 81377 Munich, Germany.; Institute of Neuronal Cell Biology, Technical University Munich, 80802 Munich, Germany.; Munich Cluster for Systems Neurology (Synergy), 81377 Munich, Germany., Suh JH; Denali Therapeutics Inc., South San Francisco, CA 94080, USA., Sandmann T; Denali Therapeutics Inc., South San Francisco, CA 94080, USA., Kariolis MS; Denali Therapeutics Inc., South San Francisco, CA 94080, USA., DeVos SL; Denali Therapeutics Inc., South San Francisco, CA 94080, USA., Lewcock JW; Denali Therapeutics Inc., South San Francisco, CA 94080, USA., Paquet D; Institute for Stroke and Dementia Research (ISD), University Hospital, LMU Munich, 81377 Munich, Germany.; Munich Cluster for Systems Neurology (Synergy), 81377 Munich, Germany., Capell A; German Center for Neurodegenerative Diseases (DZNE), 81377 Munich, Germany.; Metabolic Biochemistry, Biomedical Centre (BMC), Faculty of Medicine, LMU Munich, 81377 Munich, Germany., Di Paolo G; Denali Therapeutics Inc., South San Francisco, CA 94080, USA., Haass C; German Center for Neurodegenerative Diseases (DZNE), 81377 Munich, Germany.; Metabolic Biochemistry, Biomedical Centre (BMC), Faculty of Medicine, LMU Munich, 81377 Munich, Germany.; Munich Cluster for Systems Neurology (Synergy), 81377 Munich, Germany. |
| Source: | Science translational medicine [Sci Transl Med] 2024 Jun 05; Vol. 16 (750), pp. eadj7308. Date of Electronic Publication: 2024 Jun 05. |
| Publication Type: | Journal Article; Research Support, Non-U.S. Gov't |
| Journal Info: | Publisher: American Association for the Advancement of Science Country of Publication: United States NLM ID: 101505086 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1946-6242 (Electronic) Linking ISSN: 19466234 NLM ISO Abbreviation: Sci Transl Med Subsets: MEDLINE |
| Database: | MEDLINE Ultimate |
|
Full text is not displayed to guests.
Login for full access.
|
|
| ISSN: | 1946-6242 |
|---|---|
| DOI: | 10.1126/scitranslmed.adj7308 |
