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Peripheral expression of brain-penetrant progranulin rescues pathologies in mouse models of frontotemporal lobar degeneration.

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Title: Peripheral expression of brain-penetrant progranulin rescues pathologies in mouse models of frontotemporal lobar degeneration.
Authors: Reich M; German Center for Neurodegenerative Diseases (DZNE), 81377 Munich, Germany.; Graduate School of Systemic Neurosciences (GSN), LMU Munich, 82152 Planegg, Germany.; Institute for Stroke and Dementia Research (ISD), University Hospital, LMU Munich, 81377 Munich, Germany., Simon MJ; Denali Therapeutics Inc., South San Francisco, CA 94080, USA., Polke B; Metabolic Biochemistry, Biomedical Centre (BMC), Faculty of Medicine, LMU Munich, 81377 Munich, Germany., Paris I; Metabolic Biochemistry, Biomedical Centre (BMC), Faculty of Medicine, LMU Munich, 81377 Munich, Germany., Werner G; Metabolic Biochemistry, Biomedical Centre (BMC), Faculty of Medicine, LMU Munich, 81377 Munich, Germany., Schrader C; Metabolic Biochemistry, Biomedical Centre (BMC), Faculty of Medicine, LMU Munich, 81377 Munich, Germany., Spieth L; German Center for Neurodegenerative Diseases (DZNE), 81377 Munich, Germany.; Institute of Neuronal Cell Biology, Technical University Munich, 80802 Munich, Germany.; Max Planck Institute for Multidisciplinary Sciences, 37077 Göttingen, Germany., Davis SS; Denali Therapeutics Inc., South San Francisco, CA 94080, USA., Robinson S; Graduate School of Systemic Neurosciences (GSN), LMU Munich, 82152 Planegg, Germany.; Institute for Stroke and Dementia Research (ISD), University Hospital, LMU Munich, 81377 Munich, Germany.; Metabolic Biochemistry, Biomedical Centre (BMC), Faculty of Medicine, LMU Munich, 81377 Munich, Germany., de Melo GL; Denali Therapeutics Inc., South San Francisco, CA 94080, USA., Schlaphoff L; German Center for Neurodegenerative Diseases (DZNE), 81377 Munich, Germany.; Graduate School of Systemic Neurosciences (GSN), LMU Munich, 82152 Planegg, Germany.; Institute of Neuronal Cell Biology, Technical University Munich, 80802 Munich, Germany., Buschmann K; Metabolic Biochemistry, Biomedical Centre (BMC), Faculty of Medicine, LMU Munich, 81377 Munich, Germany., Berghoff S; German Center for Neurodegenerative Diseases (DZNE), 81377 Munich, Germany.; Institute of Neuronal Cell Biology, Technical University Munich, 80802 Munich, Germany.; Max Planck Institute for Multidisciplinary Sciences, 37077 Göttingen, Germany., Logan T; Denali Therapeutics Inc., South San Francisco, CA 94080, USA., Nuscher B; Metabolic Biochemistry, Biomedical Centre (BMC), Faculty of Medicine, LMU Munich, 81377 Munich, Germany., de Weerd L; German Center for Neurodegenerative Diseases (DZNE), 81377 Munich, Germany., Edbauer D; German Center for Neurodegenerative Diseases (DZNE), 81377 Munich, Germany.; Munich Cluster for Systems Neurology (Synergy), 81377 Munich, Germany., Simons M; German Center for Neurodegenerative Diseases (DZNE), 81377 Munich, Germany.; Institute for Stroke and Dementia Research (ISD), University Hospital, LMU Munich, 81377 Munich, Germany.; Institute of Neuronal Cell Biology, Technical University Munich, 80802 Munich, Germany.; Munich Cluster for Systems Neurology (Synergy), 81377 Munich, Germany., Suh JH; Denali Therapeutics Inc., South San Francisco, CA 94080, USA., Sandmann T; Denali Therapeutics Inc., South San Francisco, CA 94080, USA., Kariolis MS; Denali Therapeutics Inc., South San Francisco, CA 94080, USA., DeVos SL; Denali Therapeutics Inc., South San Francisco, CA 94080, USA., Lewcock JW; Denali Therapeutics Inc., South San Francisco, CA 94080, USA., Paquet D; Institute for Stroke and Dementia Research (ISD), University Hospital, LMU Munich, 81377 Munich, Germany.; Munich Cluster for Systems Neurology (Synergy), 81377 Munich, Germany., Capell A; German Center for Neurodegenerative Diseases (DZNE), 81377 Munich, Germany.; Metabolic Biochemistry, Biomedical Centre (BMC), Faculty of Medicine, LMU Munich, 81377 Munich, Germany., Di Paolo G; Denali Therapeutics Inc., South San Francisco, CA 94080, USA., Haass C; German Center for Neurodegenerative Diseases (DZNE), 81377 Munich, Germany.; Metabolic Biochemistry, Biomedical Centre (BMC), Faculty of Medicine, LMU Munich, 81377 Munich, Germany.; Munich Cluster for Systems Neurology (Synergy), 81377 Munich, Germany.
Source: Science translational medicine [Sci Transl Med] 2024 Jun 05; Vol. 16 (750), pp. eadj7308. Date of Electronic Publication: 2024 Jun 05.
Publication Type: Journal Article; Research Support, Non-U.S. Gov't
Journal Info: Publisher: American Association for the Advancement of Science Country of Publication: United States NLM ID: 101505086 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1946-6242 (Electronic) Linking ISSN: 19466234 NLM ISO Abbreviation: Sci Transl Med Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: Peripheral expression of brain-penetrant progranulin rescues pathologies in mouse models of frontotemporal lobar degeneration.
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  Data: <searchLink fieldCode="AU" term="%22Reich+M%22">Reich M</searchLink>; German Center for Neurodegenerative Diseases (DZNE), 81377 Munich, Germany.; Graduate School of Systemic Neurosciences (GSN), LMU Munich, 82152 Planegg, Germany.; Institute for Stroke and Dementia Research (ISD), University Hospital, LMU Munich, 81377 Munich, Germany.<br /><searchLink fieldCode="AU" term="%22Simon+MJ%22">Simon MJ</searchLink>; Denali Therapeutics Inc., South San Francisco, CA 94080, USA.<br /><searchLink fieldCode="AU" term="%22Polke+B%22">Polke B</searchLink>; Metabolic Biochemistry, Biomedical Centre (BMC), Faculty of Medicine, LMU Munich, 81377 Munich, Germany.<br /><searchLink fieldCode="AU" term="%22Paris+I%22">Paris I</searchLink>; Metabolic Biochemistry, Biomedical Centre (BMC), Faculty of Medicine, LMU Munich, 81377 Munich, Germany.<br /><searchLink fieldCode="AU" term="%22Werner+G%22">Werner G</searchLink>; Metabolic Biochemistry, Biomedical Centre (BMC), Faculty of Medicine, LMU Munich, 81377 Munich, Germany.<br /><searchLink fieldCode="AU" term="%22Schrader+C%22">Schrader C</searchLink>; Metabolic Biochemistry, Biomedical Centre (BMC), Faculty of Medicine, LMU Munich, 81377 Munich, Germany.<br /><searchLink fieldCode="AU" term="%22Spieth+L%22">Spieth L</searchLink>; German Center for Neurodegenerative Diseases (DZNE), 81377 Munich, Germany.; Institute of Neuronal Cell Biology, Technical University Munich, 80802 Munich, Germany.; Max Planck Institute for Multidisciplinary Sciences, 37077 Göttingen, Germany.<br /><searchLink fieldCode="AU" term="%22Davis+SS%22">Davis SS</searchLink>; Denali Therapeutics Inc., South San Francisco, CA 94080, USA.<br /><searchLink fieldCode="AU" term="%22Robinson+S%22">Robinson S</searchLink>; Graduate School of Systemic Neurosciences (GSN), LMU Munich, 82152 Planegg, Germany.; Institute for Stroke and Dementia Research (ISD), University Hospital, LMU Munich, 81377 Munich, Germany.; Metabolic Biochemistry, Biomedical Centre (BMC), Faculty of Medicine, LMU Munich, 81377 Munich, Germany.<br /><searchLink fieldCode="AU" term="%22de+Melo+GL%22">de Melo GL</searchLink>; Denali Therapeutics Inc., South San Francisco, CA 94080, USA.<br /><searchLink fieldCode="AU" term="%22Schlaphoff+L%22">Schlaphoff L</searchLink>; German Center for Neurodegenerative Diseases (DZNE), 81377 Munich, Germany.; Graduate School of Systemic Neurosciences (GSN), LMU Munich, 82152 Planegg, Germany.; Institute of Neuronal Cell Biology, Technical University Munich, 80802 Munich, Germany.<br /><searchLink fieldCode="AU" term="%22Buschmann+K%22">Buschmann K</searchLink>; Metabolic Biochemistry, Biomedical Centre (BMC), Faculty of Medicine, LMU Munich, 81377 Munich, Germany.<br /><searchLink fieldCode="AU" term="%22Berghoff+S%22">Berghoff S</searchLink>; German Center for Neurodegenerative Diseases (DZNE), 81377 Munich, Germany.; Institute of Neuronal Cell Biology, Technical University Munich, 80802 Munich, Germany.; Max Planck Institute for Multidisciplinary Sciences, 37077 Göttingen, Germany.<br /><searchLink fieldCode="AU" term="%22Logan+T%22">Logan T</searchLink>; Denali Therapeutics Inc., South San Francisco, CA 94080, USA.<br /><searchLink fieldCode="AU" term="%22Nuscher+B%22">Nuscher B</searchLink>; Metabolic Biochemistry, Biomedical Centre (BMC), Faculty of Medicine, LMU Munich, 81377 Munich, Germany.<br /><searchLink fieldCode="AU" term="%22de+Weerd+L%22">de Weerd L</searchLink>; German Center for Neurodegenerative Diseases (DZNE), 81377 Munich, Germany.<br /><searchLink fieldCode="AU" term="%22Edbauer+D%22">Edbauer D</searchLink>; German Center for Neurodegenerative Diseases (DZNE), 81377 Munich, Germany.; Munich Cluster for Systems Neurology (Synergy), 81377 Munich, Germany.<br /><searchLink fieldCode="AU" term="%22Simons+M%22">Simons M</searchLink>; German Center for Neurodegenerative Diseases (DZNE), 81377 Munich, Germany.; Institute for Stroke and Dementia Research (ISD), University Hospital, LMU Munich, 81377 Munich, Germany.; Institute of Neuronal Cell Biology, Technical University Munich, 80802 Munich, Germany.; Munich Cluster for Systems Neurology (Synergy), 81377 Munich, Germany.<br /><searchLink fieldCode="AU" term="%22Suh+JH%22">Suh JH</searchLink>; Denali Therapeutics Inc., South San Francisco, CA 94080, USA.<br /><searchLink fieldCode="AU" term="%22Sandmann+T%22">Sandmann T</searchLink>; Denali Therapeutics Inc., South San Francisco, CA 94080, USA.<br /><searchLink fieldCode="AU" term="%22Kariolis+MS%22">Kariolis MS</searchLink>; Denali Therapeutics Inc., South San Francisco, CA 94080, USA.<br /><searchLink fieldCode="AU" term="%22DeVos+SL%22">DeVos SL</searchLink>; Denali Therapeutics Inc., South San Francisco, CA 94080, USA.<br /><searchLink fieldCode="AU" term="%22Lewcock+JW%22">Lewcock JW</searchLink>; Denali Therapeutics Inc., South San Francisco, CA 94080, USA.<br /><searchLink fieldCode="AU" term="%22Paquet+D%22">Paquet D</searchLink>; Institute for Stroke and Dementia Research (ISD), University Hospital, LMU Munich, 81377 Munich, Germany.; Munich Cluster for Systems Neurology (Synergy), 81377 Munich, Germany.<br /><searchLink fieldCode="AU" term="%22Capell+A%22">Capell A</searchLink>; German Center for Neurodegenerative Diseases (DZNE), 81377 Munich, Germany.; Metabolic Biochemistry, Biomedical Centre (BMC), Faculty of Medicine, LMU Munich, 81377 Munich, Germany.<br /><searchLink fieldCode="AU" term="%22Di+Paolo+G%22">Di Paolo G</searchLink>; Denali Therapeutics Inc., South San Francisco, CA 94080, USA.<br /><searchLink fieldCode="AU" term="%22Haass+C%22">Haass C</searchLink>; German Center for Neurodegenerative Diseases (DZNE), 81377 Munich, Germany.; Metabolic Biochemistry, Biomedical Centre (BMC), Faculty of Medicine, LMU Munich, 81377 Munich, Germany.; Munich Cluster for Systems Neurology (Synergy), 81377 Munich, Germany.
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  Data: <searchLink fieldCode="JN" term="%22101505086%22">Science translational medicine</searchLink> [Sci Transl Med] 2024 Jun 05; Vol. 16 (750), pp. eadj7308. <i>Date of Electronic Publication: </i>2024 Jun 05.
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