Multiomic ALS signatures highlight subclusters and sex differences suggesting the MAPK pathway as therapeutic target.
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| Title: | Multiomic ALS signatures highlight subclusters and sex differences suggesting the MAPK pathway as therapeutic target. |
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| Authors: | Caldi Gomes L; Technical University of Munich, School of Medicine, rechts der Isar Hospital, Clinical Department of Neurology, Munich, Germany., Hänzelmann S; III. Department of Medicine, University Medical Center Hamburg-Eppendorf, Hamburg, Germany.; Center for Biomedical AI, University Medical Center Hamburg-Eppendorf, Hamburg, Germany.; Institute of Medical Systems Biology, University Medical Center Hamburg-Eppendorf, Hamburg, Germany., Hausmann F; Center for Biomedical AI, University Medical Center Hamburg-Eppendorf, Hamburg, Germany.; Institute of Medical Systems Biology, University Medical Center Hamburg-Eppendorf, Hamburg, Germany., Khatri R; Center for Biomedical AI, University Medical Center Hamburg-Eppendorf, Hamburg, Germany.; Institute of Medical Systems Biology, University Medical Center Hamburg-Eppendorf, Hamburg, Germany., Oller S; Center for Biomedical AI, University Medical Center Hamburg-Eppendorf, Hamburg, Germany.; Institute of Medical Systems Biology, University Medical Center Hamburg-Eppendorf, Hamburg, Germany., Parvaz M; Technical University of Munich, School of Medicine, rechts der Isar Hospital, Clinical Department of Neurology, Munich, Germany., Tzeplaeff L; Technical University of Munich, School of Medicine, rechts der Isar Hospital, Clinical Department of Neurology, Munich, Germany., Pasetto L; Research Center for ALS, Istituto di Ricerche Farmacologiche Mario Negri IRCCS, Milan, Italy., Gebelin M; Laboratoire de Spectrométrie de Masse Bio-Organique, Université de Strasbourg, Infrastructure Nationale de Protéomique, Strasbourg, France., Ebbing M; Center for Biomedical AI, University Medical Center Hamburg-Eppendorf, Hamburg, Germany.; Institute of Medical Systems Biology, University Medical Center Hamburg-Eppendorf, Hamburg, Germany., Holzapfel C; Center for Biomedical AI, University Medical Center Hamburg-Eppendorf, Hamburg, Germany.; Institute of Medical Systems Biology, University Medical Center Hamburg-Eppendorf, Hamburg, Germany., Columbro SF; Research Center for ALS, Istituto di Ricerche Farmacologiche Mario Negri IRCCS, Milan, Italy., Scozzari S; Research Center for ALS, Istituto di Ricerche Farmacologiche Mario Negri IRCCS, Milan, Italy., Knöferle J; Technical University of Munich, School of Medicine, rechts der Isar Hospital, Clinical Department of Neurology, Munich, Germany., Cordts I; Technical University of Munich, School of Medicine, rechts der Isar Hospital, Clinical Department of Neurology, Munich, Germany., Demleitner AF; Technical University of Munich, School of Medicine, rechts der Isar Hospital, Clinical Department of Neurology, Munich, Germany., Deschauer M; Technical University of Munich, School of Medicine, rechts der Isar Hospital, Clinical Department of Neurology, Munich, Germany., Dufke C; Institute of Medical Genetics and Applied Genomics, University of Tübingen, Tübingen, Germany., Sturm M; Institute of Medical Genetics and Applied Genomics, University of Tübingen, Tübingen, Germany., Zhou Q; German Center for Neurodegenerative Diseases (DZNE), München, Germany.; Munich Cluster for Systems Neurology (SyNergy), Munich, Germany., Zelina P; Department of Translational Neuroscience, University Medical Center Utrecht, Utrecht University, Utrecht, The Netherlands., Sudria-Lopez E; Department of Translational Neuroscience, University Medical Center Utrecht, Utrecht University, Utrecht, The Netherlands., Haack TB; Institute of Medical Genetics and Applied Genomics, University of Tübingen, Tübingen, Germany.; Center for Rare Diseases, University of Tübingen, Tübingen, Germany., Streb S; Functional Genomics Center Zürich, ETH Zürich and University of Zürich, Zürich, Switzerland., Kuzma-Kozakiewicz M; Department of Neurology, Medical University of Warsaw, Warsaw, Poland., Edbauer D; German Center for Neurodegenerative Diseases (DZNE), München, Germany.; Munich Cluster for Systems Neurology (SyNergy), Munich, Germany., Pasterkamp RJ; Department of Translational Neuroscience, University Medical Center Utrecht, Utrecht University, Utrecht, The Netherlands., Laczko E; Functional Genomics Center Zürich, ETH Zürich and University of Zürich, Zürich, Switzerland., Rehrauer H; Functional Genomics Center Zürich, ETH Zürich and University of Zürich, Zürich, Switzerland., Schlapbach R; Functional Genomics Center Zürich, ETH Zürich and University of Zürich, Zürich, Switzerland., Carapito C; Laboratoire de Spectrométrie de Masse Bio-Organique, Université de Strasbourg, Infrastructure Nationale de Protéomique, Strasbourg, France., Bonetto V; Research Center for ALS, Istituto di Ricerche Farmacologiche Mario Negri IRCCS, Milan, Italy., Bonn S; Center for Biomedical AI, University Medical Center Hamburg-Eppendorf, Hamburg, Germany. stefan.bonn@zmnh.uni-hamburg.de.; Institute of Medical Systems Biology, University Medical Center Hamburg-Eppendorf, Hamburg, Germany. stefan.bonn@zmnh.uni-hamburg.de., Lingor P; Technical University of Munich, School of Medicine, rechts der Isar Hospital, Clinical Department of Neurology, Munich, Germany. paul.lingor@tum.de.; German Center for Neurodegenerative Diseases (DZNE), München, Germany. paul.lingor@tum.de.; Munich Cluster for Systems Neurology (SyNergy), Munich, Germany. paul.lingor@tum.de. |
| Source: | Nature communications [Nat Commun] 2024 Jun 07; Vol. 15 (1), pp. 4893. Date of Electronic Publication: 2024 Jun 07. |
| Publication Type: | Journal Article |
| Journal Info: | Publisher: Nature Pub. Group Country of Publication: England NLM ID: 101528555 Publication Model: Electronic Cited Medium: Internet ISSN: 2041-1723 (Electronic) Linking ISSN: 20411723 NLM ISO Abbreviation: Nat Commun Subsets: MEDLINE |
| Database: | MEDLINE Ultimate |
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| ISSN: | 2041-1723 |
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| DOI: | 10.1038/s41467-024-49196-y |
