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Multiomic ALS signatures highlight subclusters and sex differences suggesting the MAPK pathway as therapeutic target.

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Title: Multiomic ALS signatures highlight subclusters and sex differences suggesting the MAPK pathway as therapeutic target.
Authors: Caldi Gomes L; Technical University of Munich, School of Medicine, rechts der Isar Hospital, Clinical Department of Neurology, Munich, Germany., Hänzelmann S; III. Department of Medicine, University Medical Center Hamburg-Eppendorf, Hamburg, Germany.; Center for Biomedical AI, University Medical Center Hamburg-Eppendorf, Hamburg, Germany.; Institute of Medical Systems Biology, University Medical Center Hamburg-Eppendorf, Hamburg, Germany., Hausmann F; Center for Biomedical AI, University Medical Center Hamburg-Eppendorf, Hamburg, Germany.; Institute of Medical Systems Biology, University Medical Center Hamburg-Eppendorf, Hamburg, Germany., Khatri R; Center for Biomedical AI, University Medical Center Hamburg-Eppendorf, Hamburg, Germany.; Institute of Medical Systems Biology, University Medical Center Hamburg-Eppendorf, Hamburg, Germany., Oller S; Center for Biomedical AI, University Medical Center Hamburg-Eppendorf, Hamburg, Germany.; Institute of Medical Systems Biology, University Medical Center Hamburg-Eppendorf, Hamburg, Germany., Parvaz M; Technical University of Munich, School of Medicine, rechts der Isar Hospital, Clinical Department of Neurology, Munich, Germany., Tzeplaeff L; Technical University of Munich, School of Medicine, rechts der Isar Hospital, Clinical Department of Neurology, Munich, Germany., Pasetto L; Research Center for ALS, Istituto di Ricerche Farmacologiche Mario Negri IRCCS, Milan, Italy., Gebelin M; Laboratoire de Spectrométrie de Masse Bio-Organique, Université de Strasbourg, Infrastructure Nationale de Protéomique, Strasbourg, France., Ebbing M; Center for Biomedical AI, University Medical Center Hamburg-Eppendorf, Hamburg, Germany.; Institute of Medical Systems Biology, University Medical Center Hamburg-Eppendorf, Hamburg, Germany., Holzapfel C; Center for Biomedical AI, University Medical Center Hamburg-Eppendorf, Hamburg, Germany.; Institute of Medical Systems Biology, University Medical Center Hamburg-Eppendorf, Hamburg, Germany., Columbro SF; Research Center for ALS, Istituto di Ricerche Farmacologiche Mario Negri IRCCS, Milan, Italy., Scozzari S; Research Center for ALS, Istituto di Ricerche Farmacologiche Mario Negri IRCCS, Milan, Italy., Knöferle J; Technical University of Munich, School of Medicine, rechts der Isar Hospital, Clinical Department of Neurology, Munich, Germany., Cordts I; Technical University of Munich, School of Medicine, rechts der Isar Hospital, Clinical Department of Neurology, Munich, Germany., Demleitner AF; Technical University of Munich, School of Medicine, rechts der Isar Hospital, Clinical Department of Neurology, Munich, Germany., Deschauer M; Technical University of Munich, School of Medicine, rechts der Isar Hospital, Clinical Department of Neurology, Munich, Germany., Dufke C; Institute of Medical Genetics and Applied Genomics, University of Tübingen, Tübingen, Germany., Sturm M; Institute of Medical Genetics and Applied Genomics, University of Tübingen, Tübingen, Germany., Zhou Q; German Center for Neurodegenerative Diseases (DZNE), München, Germany.; Munich Cluster for Systems Neurology (SyNergy), Munich, Germany., Zelina P; Department of Translational Neuroscience, University Medical Center Utrecht, Utrecht University, Utrecht, The Netherlands., Sudria-Lopez E; Department of Translational Neuroscience, University Medical Center Utrecht, Utrecht University, Utrecht, The Netherlands., Haack TB; Institute of Medical Genetics and Applied Genomics, University of Tübingen, Tübingen, Germany.; Center for Rare Diseases, University of Tübingen, Tübingen, Germany., Streb S; Functional Genomics Center Zürich, ETH Zürich and University of Zürich, Zürich, Switzerland., Kuzma-Kozakiewicz M; Department of Neurology, Medical University of Warsaw, Warsaw, Poland., Edbauer D; German Center for Neurodegenerative Diseases (DZNE), München, Germany.; Munich Cluster for Systems Neurology (SyNergy), Munich, Germany., Pasterkamp RJ; Department of Translational Neuroscience, University Medical Center Utrecht, Utrecht University, Utrecht, The Netherlands., Laczko E; Functional Genomics Center Zürich, ETH Zürich and University of Zürich, Zürich, Switzerland., Rehrauer H; Functional Genomics Center Zürich, ETH Zürich and University of Zürich, Zürich, Switzerland., Schlapbach R; Functional Genomics Center Zürich, ETH Zürich and University of Zürich, Zürich, Switzerland., Carapito C; Laboratoire de Spectrométrie de Masse Bio-Organique, Université de Strasbourg, Infrastructure Nationale de Protéomique, Strasbourg, France., Bonetto V; Research Center for ALS, Istituto di Ricerche Farmacologiche Mario Negri IRCCS, Milan, Italy., Bonn S; Center for Biomedical AI, University Medical Center Hamburg-Eppendorf, Hamburg, Germany. stefan.bonn@zmnh.uni-hamburg.de.; Institute of Medical Systems Biology, University Medical Center Hamburg-Eppendorf, Hamburg, Germany. stefan.bonn@zmnh.uni-hamburg.de., Lingor P; Technical University of Munich, School of Medicine, rechts der Isar Hospital, Clinical Department of Neurology, Munich, Germany. paul.lingor@tum.de.; German Center for Neurodegenerative Diseases (DZNE), München, Germany. paul.lingor@tum.de.; Munich Cluster for Systems Neurology (SyNergy), Munich, Germany. paul.lingor@tum.de.
Source: Nature communications [Nat Commun] 2024 Jun 07; Vol. 15 (1), pp. 4893. Date of Electronic Publication: 2024 Jun 07.
Publication Type: Journal Article
Journal Info: Publisher: Nature Pub. Group Country of Publication: England NLM ID: 101528555 Publication Model: Electronic Cited Medium: Internet ISSN: 2041-1723 (Electronic) Linking ISSN: 20411723 NLM ISO Abbreviation: Nat Commun Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: Multiomic ALS signatures highlight subclusters and sex differences suggesting the MAPK pathway as therapeutic target.
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  Data: <searchLink fieldCode="AU" term="%22Caldi+Gomes+L%22">Caldi Gomes L</searchLink>; Technical University of Munich, School of Medicine, rechts der Isar Hospital, Clinical Department of Neurology, Munich, Germany.<br /><searchLink fieldCode="AU" term="%22Hänzelmann+S%22">Hänzelmann S</searchLink>; III. Department of Medicine, University Medical Center Hamburg-Eppendorf, Hamburg, Germany.; Center for Biomedical AI, University Medical Center Hamburg-Eppendorf, Hamburg, Germany.; Institute of Medical Systems Biology, University Medical Center Hamburg-Eppendorf, Hamburg, Germany.<br /><searchLink fieldCode="AU" term="%22Hausmann+F%22">Hausmann F</searchLink>; Center for Biomedical AI, University Medical Center Hamburg-Eppendorf, Hamburg, Germany.; Institute of Medical Systems Biology, University Medical Center Hamburg-Eppendorf, Hamburg, Germany.<br /><searchLink fieldCode="AU" term="%22Khatri+R%22">Khatri R</searchLink>; Center for Biomedical AI, University Medical Center Hamburg-Eppendorf, Hamburg, Germany.; Institute of Medical Systems Biology, University Medical Center Hamburg-Eppendorf, Hamburg, Germany.<br /><searchLink fieldCode="AU" term="%22Oller+S%22">Oller S</searchLink>; Center for Biomedical AI, University Medical Center Hamburg-Eppendorf, Hamburg, Germany.; Institute of Medical Systems Biology, University Medical Center Hamburg-Eppendorf, Hamburg, Germany.<br /><searchLink fieldCode="AU" term="%22Parvaz+M%22">Parvaz M</searchLink>; Technical University of Munich, School of Medicine, rechts der Isar Hospital, Clinical Department of Neurology, Munich, Germany.<br /><searchLink fieldCode="AU" term="%22Tzeplaeff+L%22">Tzeplaeff L</searchLink>; Technical University of Munich, School of Medicine, rechts der Isar Hospital, Clinical Department of Neurology, Munich, Germany.<br /><searchLink fieldCode="AU" term="%22Pasetto+L%22">Pasetto L</searchLink>; Research Center for ALS, Istituto di Ricerche Farmacologiche Mario Negri IRCCS, Milan, Italy.<br /><searchLink fieldCode="AU" term="%22Gebelin+M%22">Gebelin M</searchLink>; Laboratoire de Spectrométrie de Masse Bio-Organique, Université de Strasbourg, Infrastructure Nationale de Protéomique, Strasbourg, France.<br /><searchLink fieldCode="AU" term="%22Ebbing+M%22">Ebbing M</searchLink>; Center for Biomedical AI, University Medical Center Hamburg-Eppendorf, Hamburg, Germany.; Institute of Medical Systems Biology, University Medical Center Hamburg-Eppendorf, Hamburg, Germany.<br /><searchLink fieldCode="AU" term="%22Holzapfel+C%22">Holzapfel C</searchLink>; Center for Biomedical AI, University Medical Center Hamburg-Eppendorf, Hamburg, Germany.; Institute of Medical Systems Biology, University Medical Center Hamburg-Eppendorf, Hamburg, Germany.<br /><searchLink fieldCode="AU" term="%22Columbro+SF%22">Columbro SF</searchLink>; Research Center for ALS, Istituto di Ricerche Farmacologiche Mario Negri IRCCS, Milan, Italy.<br /><searchLink fieldCode="AU" term="%22Scozzari+S%22">Scozzari S</searchLink>; Research Center for ALS, Istituto di Ricerche Farmacologiche Mario Negri IRCCS, Milan, Italy.<br /><searchLink fieldCode="AU" term="%22Knöferle+J%22">Knöferle J</searchLink>; Technical University of Munich, School of Medicine, rechts der Isar Hospital, Clinical Department of Neurology, Munich, Germany.<br /><searchLink fieldCode="AU" term="%22Cordts+I%22">Cordts I</searchLink>; Technical University of Munich, School of Medicine, rechts der Isar Hospital, Clinical Department of Neurology, Munich, Germany.<br /><searchLink fieldCode="AU" term="%22Demleitner+AF%22">Demleitner AF</searchLink>; Technical University of Munich, School of Medicine, rechts der Isar Hospital, Clinical Department of Neurology, Munich, Germany.<br /><searchLink fieldCode="AU" term="%22Deschauer+M%22">Deschauer M</searchLink>; Technical University of Munich, School of Medicine, rechts der Isar Hospital, Clinical Department of Neurology, Munich, Germany.<br /><searchLink fieldCode="AU" term="%22Dufke+C%22">Dufke C</searchLink>; Institute of Medical Genetics and Applied Genomics, University of Tübingen, Tübingen, Germany.<br /><searchLink fieldCode="AU" term="%22Sturm+M%22">Sturm M</searchLink>; Institute of Medical Genetics and Applied Genomics, University of Tübingen, Tübingen, Germany.<br /><searchLink fieldCode="AU" term="%22Zhou+Q%22">Zhou Q</searchLink>; German Center for Neurodegenerative Diseases (DZNE), München, Germany.; Munich Cluster for Systems Neurology (SyNergy), Munich, Germany.<br /><searchLink fieldCode="AU" term="%22Zelina+P%22">Zelina P</searchLink>; Department of Translational Neuroscience, University Medical Center Utrecht, Utrecht University, Utrecht, The Netherlands.<br /><searchLink fieldCode="AU" term="%22Sudria-Lopez+E%22">Sudria-Lopez E</searchLink>; Department of Translational Neuroscience, University Medical Center Utrecht, Utrecht University, Utrecht, The Netherlands.<br /><searchLink fieldCode="AU" term="%22Haack+TB%22">Haack TB</searchLink>; Institute of Medical Genetics and Applied Genomics, University of Tübingen, Tübingen, Germany.; Center for Rare Diseases, University of Tübingen, Tübingen, Germany.<br /><searchLink fieldCode="AU" term="%22Streb+S%22">Streb S</searchLink>; Functional Genomics Center Zürich, ETH Zürich and University of Zürich, Zürich, Switzerland.<br /><searchLink fieldCode="AU" term="%22Kuzma-Kozakiewicz+M%22">Kuzma-Kozakiewicz M</searchLink>; Department of Neurology, Medical University of Warsaw, Warsaw, Poland.<br /><searchLink fieldCode="AU" term="%22Edbauer+D%22">Edbauer D</searchLink>; German Center for Neurodegenerative Diseases (DZNE), München, Germany.; Munich Cluster for Systems Neurology (SyNergy), Munich, Germany.<br /><searchLink fieldCode="AU" term="%22Pasterkamp+RJ%22">Pasterkamp RJ</searchLink>; Department of Translational Neuroscience, University Medical Center Utrecht, Utrecht University, Utrecht, The Netherlands.<br /><searchLink fieldCode="AU" term="%22Laczko+E%22">Laczko E</searchLink>; Functional Genomics Center Zürich, ETH Zürich and University of Zürich, Zürich, Switzerland.<br /><searchLink fieldCode="AU" term="%22Rehrauer+H%22">Rehrauer H</searchLink>; Functional Genomics Center Zürich, ETH Zürich and University of Zürich, Zürich, Switzerland.<br /><searchLink fieldCode="AU" term="%22Schlapbach+R%22">Schlapbach R</searchLink>; Functional Genomics Center Zürich, ETH Zürich and University of Zürich, Zürich, Switzerland.<br /><searchLink fieldCode="AU" term="%22Carapito+C%22">Carapito C</searchLink>; Laboratoire de Spectrométrie de Masse Bio-Organique, Université de Strasbourg, Infrastructure Nationale de Protéomique, Strasbourg, France.<br /><searchLink fieldCode="AU" term="%22Bonetto+V%22">Bonetto V</searchLink>; Research Center for ALS, Istituto di Ricerche Farmacologiche Mario Negri IRCCS, Milan, Italy.<br /><searchLink fieldCode="AU" term="%22Bonn+S%22">Bonn S</searchLink>; Center for Biomedical AI, University Medical Center Hamburg-Eppendorf, Hamburg, Germany. stefan.bonn@zmnh.uni-hamburg.de.; Institute of Medical Systems Biology, University Medical Center Hamburg-Eppendorf, Hamburg, Germany. stefan.bonn@zmnh.uni-hamburg.de.<br /><searchLink fieldCode="AU" term="%22Lingor+P%22">Lingor P</searchLink>; Technical University of Munich, School of Medicine, rechts der Isar Hospital, Clinical Department of Neurology, Munich, Germany. paul.lingor@tum.de.; German Center for Neurodegenerative Diseases (DZNE), München, Germany. paul.lingor@tum.de.; Munich Cluster for Systems Neurology (SyNergy), Munich, Germany. paul.lingor@tum.de.
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