Improved resilience and proteostasis mediate longevity upon DAF-2 degradation in old age.
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| Title: | Improved resilience and proteostasis mediate longevity upon DAF-2 degradation in old age. |
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| Authors: | Molière A; Laboratory of Extracellular Matrix Regeneration, Institute of Translational Medicine, Department of Health Sciences and Technology, ETH Zürich, CH-8603, Schwerzenbach, Switzerland., Park JYC; Laboratory of Extracellular Matrix Regeneration, Institute of Translational Medicine, Department of Health Sciences and Technology, ETH Zürich, CH-8603, Schwerzenbach, Switzerland., Goyala A; Laboratory of Extracellular Matrix Regeneration, Institute of Translational Medicine, Department of Health Sciences and Technology, ETH Zürich, CH-8603, Schwerzenbach, Switzerland., Vayndorf EM; Department of Laboratory Medicine and Pathology, University of Washington, Seattle, WA, 98195-7470, USA., Zhang B; Institute of Healthy Ageing, and Research Department of Genetics, Evolution and Environment, University College London, London, UK., Hsiung KC; Institute of Healthy Ageing, and Research Department of Genetics, Evolution and Environment, University College London, London, UK., Jung Y; Department of Biological Sciences, Korea Advanced Institute of Science and Technology, 291 Daehak-ro, Yuseong-gu, Daejeon, 34141, South Korea., Kwon S; Department of Biological Sciences, Korea Advanced Institute of Science and Technology, 291 Daehak-ro, Yuseong-gu, Daejeon, 34141, South Korea., Statzer C; Laboratory of Extracellular Matrix Regeneration, Institute of Translational Medicine, Department of Health Sciences and Technology, ETH Zürich, CH-8603, Schwerzenbach, Switzerland., Meyer D; Institute for Genome Stability in Aging and Disease, Medical Faculty, University Hospital and University of Cologne, Joseph-Stelzmann-Str. 26, 50931, Cologne, Germany.; Cologne Excellence Cluster for Cellular Stress Responses in Aging-Associated Diseases (CECAD), Center for Molecular Medicine Cologne (CMMC), University of Cologne, Joseph-Stelzmann-Str. 26, 50931, Cologne, Germany., Nguyen R; Department of Laboratory Medicine and Pathology, University of Washington, Seattle, WA, 98195-7470, USA., Chadwick J; The Babraham Institute, Cambridge, UK., Thompson MA; The Babraham Institute, Cambridge, UK., Schumacher B; Institute for Genome Stability in Aging and Disease, Medical Faculty, University Hospital and University of Cologne, Joseph-Stelzmann-Str. 26, 50931, Cologne, Germany.; Cologne Excellence Cluster for Cellular Stress Responses in Aging-Associated Diseases (CECAD), Center for Molecular Medicine Cologne (CMMC), University of Cologne, Joseph-Stelzmann-Str. 26, 50931, Cologne, Germany., Lee SV; Department of Biological Sciences, Korea Advanced Institute of Science and Technology, 291 Daehak-ro, Yuseong-gu, Daejeon, 34141, South Korea., Essmann CL; Bioinformatics and Molecular Genetics, Institute of Biology III, Faculty of Biology, Albert-Ludwigs-University Freiburg, 79108, Freiburg, Germany., MacArthur MR; Lewis-Sigler Institute for Integrative Genomics, Princeton University, Princeton, NJ, 08540, USA., Kaeberlein M; Department of Laboratory Medicine and Pathology, University of Washington, Seattle, WA, 98195-7470, USA., David D; The Babraham Institute, Cambridge, UK., Gems D; Institute of Healthy Ageing, and Research Department of Genetics, Evolution and Environment, University College London, London, UK., Ewald CY; Laboratory of Extracellular Matrix Regeneration, Institute of Translational Medicine, Department of Health Sciences and Technology, ETH Zürich, CH-8603, Schwerzenbach, Switzerland. collin-ewald@ethz.ch. |
| Source: | GeroScience [Geroscience] 2024 Oct; Vol. 46 (5), pp. 5015-5036. Date of Electronic Publication: 2024 Jun 20. |
| Publication Type: | Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't |
| Journal Info: | Publisher: Springer International Publishing Country of Publication: Switzerland NLM ID: 101686284 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 2509-2723 (Electronic) Linking ISSN: 25092723 NLM ISO Abbreviation: Geroscience Subsets: MEDLINE |
| Database: | MEDLINE Ultimate |
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| ISSN: | 2509-2723 |
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| DOI: | 10.1007/s11357-024-01232-x |
