Impact of elexacaftor/tezacaftor/ivacaftor therapy on lung clearance index and magnetic resonance imaging in children with cystic fibrosis and one or two F508del alleles.

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Title: Impact of elexacaftor/tezacaftor/ivacaftor therapy on lung clearance index and magnetic resonance imaging in children with cystic fibrosis and one or two F508del alleles.
Authors: Stahl M; Department of Pediatric Respiratory Medicine, Immunology and Critical Care Medicine, and Cystic Fibrosis Center, Charité - Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin and Humboldt-Universität zu Berlin, Berlin, Germany mirjam.stahl@charite.de mirjam.stahl@charite.de.; Berlin Institute of Health (BIH) at Charité - Universitätsmedizin Berlin, Berlin, Germany.; German Center for Lung Research (DZL), Associated Partner Site, Berlin, Germany.; M. Stahl, M. Dohna, S.Y. Graeber and O. Sommerburg contributed equally as first authors., Dohna M; Department for Radiology, Hannover Medical School, Hannover, Germany.; M. Stahl, M. Dohna, S.Y. Graeber and O. Sommerburg contributed equally as first authors., Graeber SY; Department of Pediatric Respiratory Medicine, Immunology and Critical Care Medicine, and Cystic Fibrosis Center, Charité - Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin and Humboldt-Universität zu Berlin, Berlin, Germany.; Berlin Institute of Health (BIH) at Charité - Universitätsmedizin Berlin, Berlin, Germany.; German Center for Lung Research (DZL), Associated Partner Site, Berlin, Germany.; M. Stahl, M. Dohna, S.Y. Graeber and O. Sommerburg contributed equally as first authors., Sommerburg O; Division of Pediatric Pulmonology and Allergy, and Cystic Fibrosis Center, Department of Pediatrics, University of Heidelberg, Heidelberg, Germany.; Translational Lung Research Center Heidelberg (TLRC), German Center for Lung Research (DZL), University of Heidelberg, Heidelberg, Germany.; M. Stahl, M. Dohna, S.Y. Graeber and O. Sommerburg contributed equally as first authors., Renz DM; Department for Radiology, Hannover Medical School, Hannover, Germany., Pallenberg ST; Department for Pediatric Pneumology, Allergology and Neonatology, Hannover Medical School, Hannover, Germany.; German Center for Lung Research, Biomedical Research in Endstage and Obstructive Lung Disease (BREATH), Hannover Medical School, Hannover, Germany., Voskrebenzev A; Department for Radiology, Hannover Medical School, Hannover, Germany., Schütz K; Department for Pediatric Pneumology, Allergology and Neonatology, Hannover Medical School, Hannover, Germany.; German Center for Lung Research, Biomedical Research in Endstage and Obstructive Lung Disease (BREATH), Hannover Medical School, Hannover, Germany., Hansen G; Department for Pediatric Pneumology, Allergology and Neonatology, Hannover Medical School, Hannover, Germany.; German Center for Lung Research, Biomedical Research in Endstage and Obstructive Lung Disease (BREATH), Hannover Medical School, Hannover, Germany.; Cluster of Excellence RESIST (EXC 2155), German Research Foundation (DFG), Hannover Medical School, Hannover, Germany., Doellinger F; Department of Radiology, Charité - Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin and Humboldt-Universität zu Berlin, Berlin, Germany., Steinke E; Department of Pediatric Respiratory Medicine, Immunology and Critical Care Medicine, and Cystic Fibrosis Center, Charité - Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin and Humboldt-Universität zu Berlin, Berlin, Germany.; Berlin Institute of Health (BIH) at Charité - Universitätsmedizin Berlin, Berlin, Germany.; German Center for Lung Research (DZL), Associated Partner Site, Berlin, Germany., Thee S; Department of Pediatric Respiratory Medicine, Immunology and Critical Care Medicine, and Cystic Fibrosis Center, Charité - Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin and Humboldt-Universität zu Berlin, Berlin, Germany.; Berlin Institute of Health (BIH) at Charité - Universitätsmedizin Berlin, Berlin, Germany.; German Center for Lung Research (DZL), Associated Partner Site, Berlin, Germany., Röhmel J; Department of Pediatric Respiratory Medicine, Immunology and Critical Care Medicine, and Cystic Fibrosis Center, Charité - Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin and Humboldt-Universität zu Berlin, Berlin, Germany.; Berlin Institute of Health (BIH) at Charité - Universitätsmedizin Berlin, Berlin, Germany.; German Center for Lung Research (DZL), Associated Partner Site, Berlin, Germany., Barth S; Department of Pediatrics, Justus Liebig University Giessen, Giessen, Germany.; Universities of Giessen and Marburg Lung Center (UGMLC), German Center for Lung Research (DZL), Giessen, Germany., Rückes-Nilges C; Department of Pediatrics, Justus Liebig University Giessen, Giessen, Germany.; Universities of Giessen and Marburg Lung Center (UGMLC), German Center for Lung Research (DZL), Giessen, Germany., Berges J; Division of Pediatric Pulmonology and Allergy, and Cystic Fibrosis Center, Department of Pediatrics, University of Heidelberg, Heidelberg, Germany.; Translational Lung Research Center Heidelberg (TLRC), German Center for Lung Research (DZL), University of Heidelberg, Heidelberg, Germany., Hämmerling S; Division of Pediatric Pulmonology and Allergy, and Cystic Fibrosis Center, Department of Pediatrics, University of Heidelberg, Heidelberg, Germany., Wielpütz MO; Translational Lung Research Center Heidelberg (TLRC), German Center for Lung Research (DZL), University of Heidelberg, Heidelberg, Germany.; Department of Diagnostic and Interventional Radiology, University of Heidelberg, Heidelberg, Germany., Naehrlich L; Department of Pediatrics, Justus Liebig University Giessen, Giessen, Germany.; Universities of Giessen and Marburg Lung Center (UGMLC), German Center for Lung Research (DZL), Giessen, Germany.; L. Naehrlich, J. Vogel-Claussen, B. Tümmler, M.A. Mall and A-M. Dittrich contributed equally as senior authors., Vogel-Claussen J; Department for Radiology, Hannover Medical School, Hannover, Germany.; German Center for Lung Research, Biomedical Research in Endstage and Obstructive Lung Disease (BREATH), Hannover Medical School, Hannover, Germany.; L. Naehrlich, J. Vogel-Claussen, B. Tümmler, M.A. Mall and A-M. Dittrich contributed equally as senior authors., Tümmler B; Department for Pediatric Pneumology, Allergology and Neonatology, Hannover Medical School, Hannover, Germany.; German Center for Lung Research, Biomedical Research in Endstage and Obstructive Lung Disease (BREATH), Hannover Medical School, Hannover, Germany.; L. Naehrlich, J. Vogel-Claussen, B. Tümmler, M.A. Mall and A-M. Dittrich contributed equally as senior authors., Mall MA; Department of Pediatric Respiratory Medicine, Immunology and Critical Care Medicine, and Cystic Fibrosis Center, Charité - Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin and Humboldt-Universität zu Berlin, Berlin, Germany.; Berlin Institute of Health (BIH) at Charité - Universitätsmedizin Berlin, Berlin, Germany.; German Center for Lung Research (DZL), Associated Partner Site, Berlin, Germany.; L. Naehrlich, J. Vogel-Claussen, B. Tümmler, M.A. Mall and A-M. Dittrich contributed equally as senior authors., Dittrich AM; Department for Pediatric Pneumology, Allergology and Neonatology, Hannover Medical School, Hannover, Germany.; German Center for Lung Research, Biomedical Research in Endstage and Obstructive Lung Disease (BREATH), Hannover Medical School, Hannover, Germany.; L. Naehrlich, J. Vogel-Claussen, B. Tümmler, M.A. Mall and A-M. Dittrich contributed equally as senior authors.
Source: The European respiratory journal [Eur Respir J] 2024 Sep 05; Vol. 64 (3). Date of Electronic Publication: 2024 Sep 05 (Print Publication: 2024).
Publication Type: Journal Article; Observational Study; Multicenter Study
Journal Info: Publisher: European Respiratory Society Country of Publication: England NLM ID: 8803460 Publication Model: Electronic-Print Cited Medium: Internet ISSN: 1399-3003 (Electronic) Linking ISSN: 09031936 NLM ISO Abbreviation: Eur Respir J Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: Impact of elexacaftor/tezacaftor/ivacaftor therapy on lung clearance index and magnetic resonance imaging in children with cystic fibrosis and one or two F508del alleles.
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  Data: <searchLink fieldCode="AU" term="%22Stahl+M%22">Stahl M</searchLink>; Department of Pediatric Respiratory Medicine, Immunology and Critical Care Medicine, and Cystic Fibrosis Center, Charité - Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin and Humboldt-Universität zu Berlin, Berlin, Germany mirjam.stahl@charite.de mirjam.stahl@charite.de.; Berlin Institute of Health (BIH) at Charité - Universitätsmedizin Berlin, Berlin, Germany.; German Center for Lung Research (DZL), Associated Partner Site, Berlin, Germany.; M. Stahl, M. Dohna, S.Y. Graeber and O. Sommerburg contributed equally as first authors.<br /><searchLink fieldCode="AU" term="%22Dohna+M%22">Dohna M</searchLink>; Department for Radiology, Hannover Medical School, Hannover, Germany.; M. Stahl, M. Dohna, S.Y. Graeber and O. Sommerburg contributed equally as first authors.<br /><searchLink fieldCode="AU" term="%22Graeber+SY%22">Graeber SY</searchLink>; Department of Pediatric Respiratory Medicine, Immunology and Critical Care Medicine, and Cystic Fibrosis Center, Charité - Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin and Humboldt-Universität zu Berlin, Berlin, Germany.; Berlin Institute of Health (BIH) at Charité - Universitätsmedizin Berlin, Berlin, Germany.; German Center for Lung Research (DZL), Associated Partner Site, Berlin, Germany.; M. Stahl, M. Dohna, S.Y. Graeber and O. Sommerburg contributed equally as first authors.<br /><searchLink fieldCode="AU" term="%22Sommerburg+O%22">Sommerburg O</searchLink>; Division of Pediatric Pulmonology and Allergy, and Cystic Fibrosis Center, Department of Pediatrics, University of Heidelberg, Heidelberg, Germany.; Translational Lung Research Center Heidelberg (TLRC), German Center for Lung Research (DZL), University of Heidelberg, Heidelberg, Germany.; M. Stahl, M. Dohna, S.Y. Graeber and O. Sommerburg contributed equally as first authors.<br /><searchLink fieldCode="AU" term="%22Renz+DM%22">Renz DM</searchLink>; Department for Radiology, Hannover Medical School, Hannover, Germany.<br /><searchLink fieldCode="AU" term="%22Pallenberg+ST%22">Pallenberg ST</searchLink>; Department for Pediatric Pneumology, Allergology and Neonatology, Hannover Medical School, Hannover, Germany.; German Center for Lung Research, Biomedical Research in Endstage and Obstructive Lung Disease (BREATH), Hannover Medical School, Hannover, Germany.<br /><searchLink fieldCode="AU" term="%22Voskrebenzev+A%22">Voskrebenzev A</searchLink>; Department for Radiology, Hannover Medical School, Hannover, Germany.<br /><searchLink fieldCode="AU" term="%22Schütz+K%22">Schütz K</searchLink>; Department for Pediatric Pneumology, Allergology and Neonatology, Hannover Medical School, Hannover, Germany.; German Center for Lung Research, Biomedical Research in Endstage and Obstructive Lung Disease (BREATH), Hannover Medical School, Hannover, Germany.<br /><searchLink fieldCode="AU" term="%22Hansen+G%22">Hansen G</searchLink>; Department for Pediatric Pneumology, Allergology and Neonatology, Hannover Medical School, Hannover, Germany.; German Center for Lung Research, Biomedical Research in Endstage and Obstructive Lung Disease (BREATH), Hannover Medical School, Hannover, Germany.; Cluster of Excellence RESIST (EXC 2155), German Research Foundation (DFG), Hannover Medical School, Hannover, Germany.<br /><searchLink fieldCode="AU" term="%22Doellinger+F%22">Doellinger F</searchLink>; Department of Radiology, Charité - Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin and Humboldt-Universität zu Berlin, Berlin, Germany.<br /><searchLink fieldCode="AU" term="%22Steinke+E%22">Steinke E</searchLink>; Department of Pediatric Respiratory Medicine, Immunology and Critical Care Medicine, and Cystic Fibrosis Center, Charité - Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin and Humboldt-Universität zu Berlin, Berlin, Germany.; Berlin Institute of Health (BIH) at Charité - Universitätsmedizin Berlin, Berlin, Germany.; German Center for Lung Research (DZL), Associated Partner Site, Berlin, Germany.<br /><searchLink fieldCode="AU" term="%22Thee+S%22">Thee S</searchLink>; Department of Pediatric Respiratory Medicine, Immunology and Critical Care Medicine, and Cystic Fibrosis Center, Charité - Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin and Humboldt-Universität zu Berlin, Berlin, Germany.; Berlin Institute of Health (BIH) at Charité - Universitätsmedizin Berlin, Berlin, Germany.; German Center for Lung Research (DZL), Associated Partner Site, Berlin, Germany.<br /><searchLink fieldCode="AU" term="%22Röhmel+J%22">Röhmel J</searchLink>; Department of Pediatric Respiratory Medicine, Immunology and Critical Care Medicine, and Cystic Fibrosis Center, Charité - Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin and Humboldt-Universität zu Berlin, Berlin, Germany.; Berlin Institute of Health (BIH) at Charité - Universitätsmedizin Berlin, Berlin, Germany.; German Center for Lung Research (DZL), Associated Partner Site, Berlin, Germany.<br /><searchLink fieldCode="AU" term="%22Barth+S%22">Barth S</searchLink>; Department of Pediatrics, Justus Liebig University Giessen, Giessen, Germany.; Universities of Giessen and Marburg Lung Center (UGMLC), German Center for Lung Research (DZL), Giessen, Germany.<br /><searchLink fieldCode="AU" term="%22Rückes-Nilges+C%22">Rückes-Nilges C</searchLink>; Department of Pediatrics, Justus Liebig University Giessen, Giessen, Germany.; Universities of Giessen and Marburg Lung Center (UGMLC), German Center for Lung Research (DZL), Giessen, Germany.<br /><searchLink fieldCode="AU" term="%22Berges+J%22">Berges J</searchLink>; Division of Pediatric Pulmonology and Allergy, and Cystic Fibrosis Center, Department of Pediatrics, University of Heidelberg, Heidelberg, Germany.; Translational Lung Research Center Heidelberg (TLRC), German Center for Lung Research (DZL), University of Heidelberg, Heidelberg, Germany.<br /><searchLink fieldCode="AU" term="%22Hämmerling+S%22">Hämmerling S</searchLink>; Division of Pediatric Pulmonology and Allergy, and Cystic Fibrosis Center, Department of Pediatrics, University of Heidelberg, Heidelberg, Germany.<br /><searchLink fieldCode="AU" term="%22Wielpütz+MO%22">Wielpütz MO</searchLink>; Translational Lung Research Center Heidelberg (TLRC), German Center for Lung Research (DZL), University of Heidelberg, Heidelberg, Germany.; Department of Diagnostic and Interventional Radiology, University of Heidelberg, Heidelberg, Germany.<br /><searchLink fieldCode="AU" term="%22Naehrlich+L%22">Naehrlich L</searchLink>; Department of Pediatrics, Justus Liebig University Giessen, Giessen, Germany.; Universities of Giessen and Marburg Lung Center (UGMLC), German Center for Lung Research (DZL), Giessen, Germany.; L. Naehrlich, J. Vogel-Claussen, B. Tümmler, M.A. Mall and A-M. Dittrich contributed equally as senior authors.<br /><searchLink fieldCode="AU" term="%22Vogel-Claussen+J%22">Vogel-Claussen J</searchLink>; Department for Radiology, Hannover Medical School, Hannover, Germany.; German Center for Lung Research, Biomedical Research in Endstage and Obstructive Lung Disease (BREATH), Hannover Medical School, Hannover, Germany.; L. Naehrlich, J. Vogel-Claussen, B. Tümmler, M.A. Mall and A-M. Dittrich contributed equally as senior authors.<br /><searchLink fieldCode="AU" term="%22Tümmler+B%22">Tümmler B</searchLink>; Department for Pediatric Pneumology, Allergology and Neonatology, Hannover Medical School, Hannover, Germany.; German Center for Lung Research, Biomedical Research in Endstage and Obstructive Lung Disease (BREATH), Hannover Medical School, Hannover, Germany.; L. Naehrlich, J. Vogel-Claussen, B. Tümmler, M.A. Mall and A-M. Dittrich contributed equally as senior authors.<br /><searchLink fieldCode="AU" term="%22Mall+MA%22">Mall MA</searchLink>; Department of Pediatric Respiratory Medicine, Immunology and Critical Care Medicine, and Cystic Fibrosis Center, Charité - Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin and Humboldt-Universität zu Berlin, Berlin, Germany.; Berlin Institute of Health (BIH) at Charité - Universitätsmedizin Berlin, Berlin, Germany.; German Center for Lung Research (DZL), Associated Partner Site, Berlin, Germany.; L. Naehrlich, J. Vogel-Claussen, B. Tümmler, M.A. Mall and A-M. Dittrich contributed equally as senior authors.<br /><searchLink fieldCode="AU" term="%22Dittrich+AM%22">Dittrich AM</searchLink>; Department for Pediatric Pneumology, Allergology and Neonatology, Hannover Medical School, Hannover, Germany.; German Center for Lung Research, Biomedical Research in Endstage and Obstructive Lung Disease (BREATH), Hannover Medical School, Hannover, Germany.; L. Naehrlich, J. Vogel-Claussen, B. Tümmler, M.A. Mall and A-M. Dittrich contributed equally as senior authors.
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