Activation of the Keap1/Nrf2 pathway suppresses mitochondrial dysfunction, oxidative stress, and motor phenotypes in C9orf72 ALS/FTD models.

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Title: Activation of the Keap1/Nrf2 pathway suppresses mitochondrial dysfunction, oxidative stress, and motor phenotypes in C9orf72 ALS/FTD models.
Authors: Au WH; MRC Mitochondrial Biology Unit, University of Cambridge, Cambridge, UK.; John van Geest Centre for Brain Repair, Department of Clinical Neurosciences, University of Cambridge, Cambridge, UK., Miller-Fleming L; MRC Mitochondrial Biology Unit, University of Cambridge, Cambridge, UK., Sanchez-Martinez A; MRC Mitochondrial Biology Unit, University of Cambridge, Cambridge, UK., Lee JA; Sheffield Institute for Translational Neuroscience (SITraN), School of Medicine and Population Health, University of Sheffield, Sheffield, UK., Twyning MJ; MRC Mitochondrial Biology Unit, University of Cambridge, Cambridge, UK., Prag HA; MRC Mitochondrial Biology Unit, University of Cambridge, Cambridge, UK.; Department of Medicine, University of Cambridge, Cambridge, UK., Raik L; MRC Mitochondrial Biology Unit, University of Cambridge, Cambridge, UK., Allen SP; Sheffield Institute for Translational Neuroscience (SITraN), School of Medicine and Population Health, University of Sheffield, Sheffield, UK., Shaw PJ; Sheffield Institute for Translational Neuroscience (SITraN), School of Medicine and Population Health, University of Sheffield, Sheffield, UK.; NIHR Sheffield Biomedical Research Centre, Sheffield Teaching Hospitals NHS Foundation Trust, Sheffield, UK., Ferraiuolo L; Sheffield Institute for Translational Neuroscience (SITraN), School of Medicine and Population Health, University of Sheffield, Sheffield, UK., Mortiboys H; Sheffield Institute for Translational Neuroscience (SITraN), School of Medicine and Population Health, University of Sheffield, Sheffield, UK., Whitworth AJ; MRC Mitochondrial Biology Unit, University of Cambridge, Cambridge, UK a.whitworth@mrc-mbu.cam.ac.uk.
Source: Life science alliance [Life Sci Alliance] 2024 Jun 21; Vol. 7 (9). Date of Electronic Publication: 2024 Jun 21 (Print Publication: 2024).
Publication Type: Journal Article; Research Support, Non-U.S. Gov't
Journal Info: Publisher: Life Science Alliance, LLC Country of Publication: United States NLM ID: 101728869 Publication Model: Electronic-Print Cited Medium: Internet ISSN: 2575-1077 (Electronic) Linking ISSN: 25751077 NLM ISO Abbreviation: Life Sci Alliance Subsets: MEDLINE
Database: MEDLINE Ultimate
Description
ISSN:2575-1077
DOI:10.26508/lsa.202402853