Activation of the Keap1/Nrf2 pathway suppresses mitochondrial dysfunction, oxidative stress, and motor phenotypes in C9orf72 ALS/FTD models.
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| Title: | Activation of the Keap1/Nrf2 pathway suppresses mitochondrial dysfunction, oxidative stress, and motor phenotypes in C9orf72 ALS/FTD models. |
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| Authors: | Au WH; MRC Mitochondrial Biology Unit, University of Cambridge, Cambridge, UK.; John van Geest Centre for Brain Repair, Department of Clinical Neurosciences, University of Cambridge, Cambridge, UK., Miller-Fleming L; MRC Mitochondrial Biology Unit, University of Cambridge, Cambridge, UK., Sanchez-Martinez A; MRC Mitochondrial Biology Unit, University of Cambridge, Cambridge, UK., Lee JA; Sheffield Institute for Translational Neuroscience (SITraN), School of Medicine and Population Health, University of Sheffield, Sheffield, UK., Twyning MJ; MRC Mitochondrial Biology Unit, University of Cambridge, Cambridge, UK., Prag HA; MRC Mitochondrial Biology Unit, University of Cambridge, Cambridge, UK.; Department of Medicine, University of Cambridge, Cambridge, UK., Raik L; MRC Mitochondrial Biology Unit, University of Cambridge, Cambridge, UK., Allen SP; Sheffield Institute for Translational Neuroscience (SITraN), School of Medicine and Population Health, University of Sheffield, Sheffield, UK., Shaw PJ; Sheffield Institute for Translational Neuroscience (SITraN), School of Medicine and Population Health, University of Sheffield, Sheffield, UK.; NIHR Sheffield Biomedical Research Centre, Sheffield Teaching Hospitals NHS Foundation Trust, Sheffield, UK., Ferraiuolo L; Sheffield Institute for Translational Neuroscience (SITraN), School of Medicine and Population Health, University of Sheffield, Sheffield, UK., Mortiboys H; Sheffield Institute for Translational Neuroscience (SITraN), School of Medicine and Population Health, University of Sheffield, Sheffield, UK., Whitworth AJ; MRC Mitochondrial Biology Unit, University of Cambridge, Cambridge, UK a.whitworth@mrc-mbu.cam.ac.uk. |
| Source: | Life science alliance [Life Sci Alliance] 2024 Jun 21; Vol. 7 (9). Date of Electronic Publication: 2024 Jun 21 (Print Publication: 2024). |
| Publication Type: | Journal Article; Research Support, Non-U.S. Gov't |
| Journal Info: | Publisher: Life Science Alliance, LLC Country of Publication: United States NLM ID: 101728869 Publication Model: Electronic-Print Cited Medium: Internet ISSN: 2575-1077 (Electronic) Linking ISSN: 25751077 NLM ISO Abbreviation: Life Sci Alliance Subsets: MEDLINE |
| Database: | MEDLINE Ultimate |
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