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Single-nucleus sequencing reveals enriched expression of genetic risk factors in extratelencephalic neurons sensitive to degeneration in ALS.

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Title: Single-nucleus sequencing reveals enriched expression of genetic risk factors in extratelencephalic neurons sensitive to degeneration in ALS.
Authors: Limone F; Department of Stem Cell and Regenerative Biology, Harvard University, Cambridge, MA, USA. francesco.limone@nyulangone.org.; Stanley Center for Psychiatric Research, Broad Institute of MIT and Harvard, Cambridge, MA, USA. francesco.limone@nyulangone.org.; Neuroscience Institute, NYU Grossman School of Medicine, New York, NY, USA. francesco.limone@nyulangone.org., Mordes DA; Department of Stem Cell and Regenerative Biology, Harvard University, Cambridge, MA, USA.; Stanley Center for Psychiatric Research, Broad Institute of MIT and Harvard, Cambridge, MA, USA.; Department of Pathology, Massachusetts General Hospital, Boston, MA, USA., Couto A; Department of Stem Cell and Regenerative Biology, Harvard University, Cambridge, MA, USA., Joseph BJ; Department of Stem Cell and Regenerative Biology, Harvard University, Cambridge, MA, USA., Mitchell JM; Department of Stem Cell and Regenerative Biology, Harvard University, Cambridge, MA, USA.; Stanley Center for Psychiatric Research, Broad Institute of MIT and Harvard, Cambridge, MA, USA., Therrien M; Stanley Center for Psychiatric Research, Broad Institute of MIT and Harvard, Cambridge, MA, USA.; FM Kirby Neurobiology Center, Boston Children's Hospital, Boston, MA, USA., Ghosh SD; Department of Stem Cell and Regenerative Biology, Harvard University, Cambridge, MA, USA.; Stanley Center for Psychiatric Research, Broad Institute of MIT and Harvard, Cambridge, MA, USA.; Department of Genetics, Harvard Medical School, Boston, MA, USA., Meyer D; Stanley Center for Psychiatric Research, Broad Institute of MIT and Harvard, Cambridge, MA, USA.; Department of Genetics, Harvard Medical School, Boston, MA, USA., Zhang Y; Department of Stem Cell and Regenerative Biology, Harvard University, Cambridge, MA, USA.; Stanley Center for Psychiatric Research, Broad Institute of MIT and Harvard, Cambridge, MA, USA., Goldman M; Stanley Center for Psychiatric Research, Broad Institute of MIT and Harvard, Cambridge, MA, USA.; Department of Genetics, Harvard Medical School, Boston, MA, USA., Bortolin L; Stanley Center for Psychiatric Research, Broad Institute of MIT and Harvard, Cambridge, MA, USA.; Department of Genetics, Harvard Medical School, Boston, MA, USA., Cobos I; Department of Pathology, Massachusetts General Hospital, Boston, MA, USA., Stevens B; Stanley Center for Psychiatric Research, Broad Institute of MIT and Harvard, Cambridge, MA, USA.; FM Kirby Neurobiology Center, Boston Children's Hospital, Boston, MA, USA.; Howard Hughes Medical Institute, Boston, MA, USA., McCarroll SA; Stanley Center for Psychiatric Research, Broad Institute of MIT and Harvard, Cambridge, MA, USA.; Department of Genetics, Harvard Medical School, Boston, MA, USA., Kadiu I; Neuroinflammation Focus Area, UCB Pharma, Braine-l'Alleud, Belgium., Burberry A; Department of Stem Cell and Regenerative Biology, Harvard University, Cambridge, MA, USA.; Stanley Center for Psychiatric Research, Broad Institute of MIT and Harvard, Cambridge, MA, USA.; Department of Pathology, School of Medicine, Case Western Reserve University, Cleveland, OH, USA., Pietiläinen O; Department of Stem Cell and Regenerative Biology, Harvard University, Cambridge, MA, USA.; Stanley Center for Psychiatric Research, Broad Institute of MIT and Harvard, Cambridge, MA, USA.; Neuroscience Center, Helsinki Institute of Life Science, University of Helsinki, Helsinki, Finland., Eggan K; Department of Stem Cell and Regenerative Biology, Harvard University, Cambridge, MA, USA. kevin.eggan@bmrn.com.; Stanley Center for Psychiatric Research, Broad Institute of MIT and Harvard, Cambridge, MA, USA. kevin.eggan@bmrn.com.
Source: Nature aging [Nat Aging] 2024 Jul; Vol. 4 (7), pp. 984-997. Date of Electronic Publication: 2024 Jun 21.
Publication Type: Journal Article
Journal Info: Publisher: Nature Publishing Group US Country of Publication: United States NLM ID: 101773306 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 2662-8465 (Electronic) Linking ISSN: 26628465 NLM ISO Abbreviation: Nat Aging Subsets: MEDLINE
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  Data: Single-nucleus sequencing reveals enriched expression of genetic risk factors in extratelencephalic neurons sensitive to degeneration in ALS.
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  Data: <searchLink fieldCode="AU" term="%22Limone+F%22">Limone F</searchLink>; Department of Stem Cell and Regenerative Biology, Harvard University, Cambridge, MA, USA. francesco.limone@nyulangone.org.; Stanley Center for Psychiatric Research, Broad Institute of MIT and Harvard, Cambridge, MA, USA. francesco.limone@nyulangone.org.; Neuroscience Institute, NYU Grossman School of Medicine, New York, NY, USA. francesco.limone@nyulangone.org.<br /><searchLink fieldCode="AU" term="%22Mordes+DA%22">Mordes DA</searchLink>; Department of Stem Cell and Regenerative Biology, Harvard University, Cambridge, MA, USA.; Stanley Center for Psychiatric Research, Broad Institute of MIT and Harvard, Cambridge, MA, USA.; Department of Pathology, Massachusetts General Hospital, Boston, MA, USA.<br /><searchLink fieldCode="AU" term="%22Couto+A%22">Couto A</searchLink>; Department of Stem Cell and Regenerative Biology, Harvard University, Cambridge, MA, USA.<br /><searchLink fieldCode="AU" term="%22Joseph+BJ%22">Joseph BJ</searchLink>; Department of Stem Cell and Regenerative Biology, Harvard University, Cambridge, MA, USA.<br /><searchLink fieldCode="AU" term="%22Mitchell+JM%22">Mitchell JM</searchLink>; Department of Stem Cell and Regenerative Biology, Harvard University, Cambridge, MA, USA.; Stanley Center for Psychiatric Research, Broad Institute of MIT and Harvard, Cambridge, MA, USA.<br /><searchLink fieldCode="AU" term="%22Therrien+M%22">Therrien M</searchLink>; Stanley Center for Psychiatric Research, Broad Institute of MIT and Harvard, Cambridge, MA, USA.; FM Kirby Neurobiology Center, Boston Children's Hospital, Boston, MA, USA.<br /><searchLink fieldCode="AU" term="%22Ghosh+SD%22">Ghosh SD</searchLink>; Department of Stem Cell and Regenerative Biology, Harvard University, Cambridge, MA, USA.; Stanley Center for Psychiatric Research, Broad Institute of MIT and Harvard, Cambridge, MA, USA.; Department of Genetics, Harvard Medical School, Boston, MA, USA.<br /><searchLink fieldCode="AU" term="%22Meyer+D%22">Meyer D</searchLink>; Stanley Center for Psychiatric Research, Broad Institute of MIT and Harvard, Cambridge, MA, USA.; Department of Genetics, Harvard Medical School, Boston, MA, USA.<br /><searchLink fieldCode="AU" term="%22Zhang+Y%22">Zhang Y</searchLink>; Department of Stem Cell and Regenerative Biology, Harvard University, Cambridge, MA, USA.; Stanley Center for Psychiatric Research, Broad Institute of MIT and Harvard, Cambridge, MA, USA.<br /><searchLink fieldCode="AU" term="%22Goldman+M%22">Goldman M</searchLink>; Stanley Center for Psychiatric Research, Broad Institute of MIT and Harvard, Cambridge, MA, USA.; Department of Genetics, Harvard Medical School, Boston, MA, USA.<br /><searchLink fieldCode="AU" term="%22Bortolin+L%22">Bortolin L</searchLink>; Stanley Center for Psychiatric Research, Broad Institute of MIT and Harvard, Cambridge, MA, USA.; Department of Genetics, Harvard Medical School, Boston, MA, USA.<br /><searchLink fieldCode="AU" term="%22Cobos+I%22">Cobos I</searchLink>; Department of Pathology, Massachusetts General Hospital, Boston, MA, USA.<br /><searchLink fieldCode="AU" term="%22Stevens+B%22">Stevens B</searchLink>; Stanley Center for Psychiatric Research, Broad Institute of MIT and Harvard, Cambridge, MA, USA.; FM Kirby Neurobiology Center, Boston Children's Hospital, Boston, MA, USA.; Howard Hughes Medical Institute, Boston, MA, USA.<br /><searchLink fieldCode="AU" term="%22McCarroll+SA%22">McCarroll SA</searchLink>; Stanley Center for Psychiatric Research, Broad Institute of MIT and Harvard, Cambridge, MA, USA.; Department of Genetics, Harvard Medical School, Boston, MA, USA.<br /><searchLink fieldCode="AU" term="%22Kadiu+I%22">Kadiu I</searchLink>; Neuroinflammation Focus Area, UCB Pharma, Braine-l'Alleud, Belgium.<br /><searchLink fieldCode="AU" term="%22Burberry+A%22">Burberry A</searchLink>; Department of Stem Cell and Regenerative Biology, Harvard University, Cambridge, MA, USA.; Stanley Center for Psychiatric Research, Broad Institute of MIT and Harvard, Cambridge, MA, USA.; Department of Pathology, School of Medicine, Case Western Reserve University, Cleveland, OH, USA.<br /><searchLink fieldCode="AU" term="%22Pietiläinen+O%22">Pietiläinen O</searchLink>; Department of Stem Cell and Regenerative Biology, Harvard University, Cambridge, MA, USA.; Stanley Center for Psychiatric Research, Broad Institute of MIT and Harvard, Cambridge, MA, USA.; Neuroscience Center, Helsinki Institute of Life Science, University of Helsinki, Helsinki, Finland.<br /><searchLink fieldCode="AU" term="%22Eggan+K%22">Eggan K</searchLink>; Department of Stem Cell and Regenerative Biology, Harvard University, Cambridge, MA, USA. kevin.eggan@bmrn.com.; Stanley Center for Psychiatric Research, Broad Institute of MIT and Harvard, Cambridge, MA, USA. kevin.eggan@bmrn.com.
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  Data: <searchLink fieldCode="JN" term="%22101773306%22">Nature aging</searchLink> [Nat Aging] 2024 Jul; Vol. 4 (7), pp. 984-997. <i>Date of Electronic Publication: </i>2024 Jun 21.
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