Development of SYK NanoBRET Cellular Target Engagement Assays for Gain-of-Function Variants.
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| Title: | Development of SYK NanoBRET Cellular Target Engagement Assays for Gain-of-Function Variants. |
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| Authors: | Capener JL; Structural Genomics Consortium, Division of Chemical Biology and Medicinal Chemistry, Eshelman School of Pharmacy, The University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA., Vasta JD; Promega Corporation, 2800 Woods Hollow Road, Madison, WI 53711, USA., Katis VL; ARUK Oxford Drug Discovery Institute, Centre for Medicines Discovery, Nuffield Department of Medicine, University of Oxford, Oxford OX3 7FZ, UK., Michaud A; Promega Corporation, 2800 Woods Hollow Road, Madison, WI 53711, USA., Beck MT; Promega Corporation, 2800 Woods Hollow Road, Madison, WI 53711, USA., Daglish SCD; Structural Genomics Consortium, Division of Chemical Biology and Medicinal Chemistry, Eshelman School of Pharmacy, The University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA., Cohen-Kedar S; Division of Gastroenterology, Rabin Medical Center, Petah-Tikva, Israel.; Felsenstein Medical Research Center, Faculty of Medical & Health Sciences, Tel-Aviv University, Tel-Aviv, Israel., Barda ES; Division of Gastroenterology, Rabin Medical Center, Petah-Tikva, Israel.; Felsenstein Medical Research Center, Faculty of Medical & Health Sciences, Tel-Aviv University, Tel-Aviv, Israel., Howell S; Structural Genomics Consortium, Division of Chemical Biology and Medicinal Chemistry, Eshelman School of Pharmacy, The University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA., Dotan I; Division of Gastroenterology, Rabin Medical Center, Petah-Tikva, Israel.; Felsenstein Medical Research Center, Faculty of Medical & Health Sciences, Tel-Aviv University, Tel-Aviv, Israel., Robers MB; Promega Corporation, 2800 Woods Hollow Road, Madison, WI 53711, USA., Axtman AD; Structural Genomics Consortium, Division of Chemical Biology and Medicinal Chemistry, Eshelman School of Pharmacy, The University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA., Bashore FM; Structural Genomics Consortium, Division of Chemical Biology and Medicinal Chemistry, Eshelman School of Pharmacy, The University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA. |
| Source: | BioRxiv : the preprint server for biology [bioRxiv] 2024 Jun 13. Date of Electronic Publication: 2024 Jun 13. |
| Publication Type: | Journal Article; Preprint |
| Journal Info: | Country of Publication: United States NLM ID: 101680187 Publication Model: Electronic Cited Medium: Internet ISSN: 2692-8205 (Electronic) Linking ISSN: 26928205 NLM ISO Abbreviation: bioRxiv Subsets: PubMed not MEDLINE |
| Database: | MEDLINE Ultimate |
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