Xenografted human iPSC-derived neurons with the familial Alzheimer's disease APPV717I mutation reveal dysregulated transcriptome signatures linked to synaptic function and implicate LINGO2 as a disease signaling mediator.
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| Title: | Xenografted human iPSC-derived neurons with the familial Alzheimer's disease APPV717I mutation reveal dysregulated transcriptome signatures linked to synaptic function and implicate LINGO2 as a disease signaling mediator. |
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| Authors: | Qu W; Department of Pathology and Cell Biology, Presbyterian Hospital, Columbia University, 650W 168th Street, New York, NY, USA., Lam M; Department of Neurology, Center for Translational and Computational Neuroimmunology, Neurological Institute, Columbia University, 710 West 168th Street, New York, NY, USA., McInvale JJ; Department of Pathology and Cell Biology, Presbyterian Hospital, Columbia University, 650W 168th Street, New York, NY, USA., Mares JA; Department of Neurology, Center for Translational and Computational Neuroimmunology, Neurological Institute, Columbia University, 710 West 168th Street, New York, NY, USA., Kwon S; Department of Pathology and Cell Biology, Presbyterian Hospital, Columbia University, 650W 168th Street, New York, NY, USA., Humala N; Department of Neurosurgery, Columbia University, New York, NY, USA., Mahajan A; Department of Neurosurgery, Columbia University, New York, NY, USA., Nguyen T; Department of Pathology and Cell Biology, Presbyterian Hospital, Columbia University, 650W 168th Street, New York, NY, USA., Jakubiak KA; Department of Pathology and Cell Biology, Presbyterian Hospital, Columbia University, 650W 168th Street, New York, NY, USA., Mun JY; Department of Pathology and Cell Biology, Presbyterian Hospital, Columbia University, 650W 168th Street, New York, NY, USA., Tedesco TG; Taub Institute for Research on Alzheimer's Disease and the Aging Brain, Columbia University, New York, NY, USA., Al-Dalahmah O; Department of Pathology and Cell Biology, Presbyterian Hospital, Columbia University, 650W 168th Street, New York, NY, USA., Hussaini SA; Taub Institute for Research on Alzheimer's Disease and the Aging Brain, Columbia University, New York, NY, USA., Sproul AA; Department of Pathology and Cell Biology, Presbyterian Hospital, Columbia University, 650W 168th Street, New York, NY, USA.; Taub Institute for Research on Alzheimer's Disease and the Aging Brain, Columbia University, New York, NY, USA., Siegelin MD; Department of Pathology and Cell Biology, Presbyterian Hospital, Columbia University, 650W 168th Street, New York, NY, USA., De Jager PL; Department of Neurology, Center for Translational and Computational Neuroimmunology, Neurological Institute, Columbia University, 710 West 168th Street, New York, NY, USA.; Taub Institute for Research on Alzheimer's Disease and the Aging Brain, Columbia University, New York, NY, USA., Canoll P; Department of Pathology and Cell Biology, Presbyterian Hospital, Columbia University, 650W 168th Street, New York, NY, USA., Menon V; Department of Neurology, Center for Translational and Computational Neuroimmunology, Neurological Institute, Columbia University, 710 West 168th Street, New York, NY, USA. vm2545@cumc.columbia.edu.; Taub Institute for Research on Alzheimer's Disease and the Aging Brain, Columbia University, New York, NY, USA. vm2545@cumc.columbia.edu., Hargus G; Department of Pathology and Cell Biology, Presbyterian Hospital, Columbia University, 650W 168th Street, New York, NY, USA. gh2374@cumc.columbia.edu.; Taub Institute for Research on Alzheimer's Disease and the Aging Brain, Columbia University, New York, NY, USA. gh2374@cumc.columbia.edu. |
| Source: | Acta neuropathologica [Acta Neuropathol] 2024 Jun 25; Vol. 147 (1), pp. 107. Date of Electronic Publication: 2024 Jun 25. |
| Publication Type: | Journal Article; Research Support, Non-U.S. Gov't; Research Support, N.I.H., Extramural |
| Journal Info: | Publisher: Springer Verlag Country of Publication: Germany NLM ID: 0412041 Publication Model: Electronic Cited Medium: Internet ISSN: 1432-0533 (Electronic) Linking ISSN: 00016322 NLM ISO Abbreviation: Acta Neuropathol Subsets: MEDLINE |
| Database: | MEDLINE Ultimate |
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| Header | DbId: mdl DbLabel: MEDLINE Ultimate An: 38918213 AccessLevel: 2 PubType: Academic Journal PubTypeId: academicJournal PreciseRelevancyScore: 0 |
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| Items | – Name: Title Label: Title Group: Ti Data: Xenografted human iPSC-derived neurons with the familial Alzheimer's disease APP<superscript>V717I</superscript> mutation reveal dysregulated transcriptome signatures linked to synaptic function and implicate LINGO2 as a disease signaling mediator. – Name: Author Label: Authors Group: Au Data: <searchLink fieldCode="AU" term="%22Qu+W%22">Qu W</searchLink>; Department of Pathology and Cell Biology, Presbyterian Hospital, Columbia University, 650W 168th Street, New York, NY, USA.<br /><searchLink fieldCode="AU" term="%22Lam+M%22">Lam M</searchLink>; Department of Neurology, Center for Translational and Computational Neuroimmunology, Neurological Institute, Columbia University, 710 West 168th Street, New York, NY, USA.<br /><searchLink fieldCode="AU" term="%22McInvale+JJ%22">McInvale JJ</searchLink>; Department of Pathology and Cell Biology, Presbyterian Hospital, Columbia University, 650W 168th Street, New York, NY, USA.<br /><searchLink fieldCode="AU" term="%22Mares+JA%22">Mares JA</searchLink>; Department of Neurology, Center for Translational and Computational Neuroimmunology, Neurological Institute, Columbia University, 710 West 168th Street, New York, NY, USA.<br /><searchLink fieldCode="AU" term="%22Kwon+S%22">Kwon S</searchLink>; Department of Pathology and Cell Biology, Presbyterian Hospital, Columbia University, 650W 168th Street, New York, NY, USA.<br /><searchLink fieldCode="AU" term="%22Humala+N%22">Humala N</searchLink>; Department of Neurosurgery, Columbia University, New York, NY, USA.<br /><searchLink fieldCode="AU" term="%22Mahajan+A%22">Mahajan A</searchLink>; Department of Neurosurgery, Columbia University, New York, NY, USA.<br /><searchLink fieldCode="AU" term="%22Nguyen+T%22">Nguyen T</searchLink>; Department of Pathology and Cell Biology, Presbyterian Hospital, Columbia University, 650W 168th Street, New York, NY, USA.<br /><searchLink fieldCode="AU" term="%22Jakubiak+KA%22">Jakubiak KA</searchLink>; Department of Pathology and Cell Biology, Presbyterian Hospital, Columbia University, 650W 168th Street, New York, NY, USA.<br /><searchLink fieldCode="AU" term="%22Mun+JY%22">Mun JY</searchLink>; Department of Pathology and Cell Biology, Presbyterian Hospital, Columbia University, 650W 168th Street, New York, NY, USA.<br /><searchLink fieldCode="AU" term="%22Tedesco+TG%22">Tedesco TG</searchLink>; Taub Institute for Research on Alzheimer's Disease and the Aging Brain, Columbia University, New York, NY, USA.<br /><searchLink fieldCode="AU" term="%22Al-Dalahmah+O%22">Al-Dalahmah O</searchLink>; Department of Pathology and Cell Biology, Presbyterian Hospital, Columbia University, 650W 168th Street, New York, NY, USA.<br /><searchLink fieldCode="AU" term="%22Hussaini+SA%22">Hussaini SA</searchLink>; Taub Institute for Research on Alzheimer's Disease and the Aging Brain, Columbia University, New York, NY, USA.<br /><searchLink fieldCode="AU" term="%22Sproul+AA%22">Sproul AA</searchLink>; Department of Pathology and Cell Biology, Presbyterian Hospital, Columbia University, 650W 168th Street, New York, NY, USA.; Taub Institute for Research on Alzheimer's Disease and the Aging Brain, Columbia University, New York, NY, USA.<br /><searchLink fieldCode="AU" term="%22Siegelin+MD%22">Siegelin MD</searchLink>; Department of Pathology and Cell Biology, Presbyterian Hospital, Columbia University, 650W 168th Street, New York, NY, USA.<br /><searchLink fieldCode="AU" term="%22De+Jager+PL%22">De Jager PL</searchLink>; Department of Neurology, Center for Translational and Computational Neuroimmunology, Neurological Institute, Columbia University, 710 West 168th Street, New York, NY, USA.; Taub Institute for Research on Alzheimer's Disease and the Aging Brain, Columbia University, New York, NY, USA.<br /><searchLink fieldCode="AU" term="%22Canoll+P%22">Canoll P</searchLink>; Department of Pathology and Cell Biology, Presbyterian Hospital, Columbia University, 650W 168th Street, New York, NY, USA.<br /><searchLink fieldCode="AU" term="%22Menon+V%22">Menon V</searchLink>; Department of Neurology, Center for Translational and Computational Neuroimmunology, Neurological Institute, Columbia University, 710 West 168th Street, New York, NY, USA. vm2545@cumc.columbia.edu.; Taub Institute for Research on Alzheimer's Disease and the Aging Brain, Columbia University, New York, NY, USA. vm2545@cumc.columbia.edu.<br /><searchLink fieldCode="AU" term="%22Hargus+G%22">Hargus G</searchLink>; Department of Pathology and Cell Biology, Presbyterian Hospital, Columbia University, 650W 168th Street, New York, NY, USA. gh2374@cumc.columbia.edu.; Taub Institute for Research on Alzheimer's Disease and the Aging Brain, Columbia University, New York, NY, USA. gh2374@cumc.columbia.edu. – Name: TitleSource Label: Source Group: Src Data: <searchLink fieldCode="JN" term="%220412041%22">Acta neuropathologica</searchLink> [Acta Neuropathol] 2024 Jun 25; Vol. 147 (1), pp. 107. <i>Date of Electronic Publication: </i>2024 Jun 25. – Name: TypePub Label: Publication Type Group: TypPub Data: Journal Article; Research Support, Non-U.S. Gov't; Research Support, N.I.H., Extramural – Name: TitleSource Label: Journal Info Group: Src Data: <i>Publisher: </i><searchLink fieldCode="PB" term="%22Springer+Verlag%22">Springer Verlag </searchLink><i>Country of Publication: </i>Germany <i>NLM ID: </i>0412041 <i>Publication Model: </i>Electronic <i>Cited Medium: </i>Internet <i>ISSN: </i>1432-0533 (Electronic) <i>Linking ISSN: </i><searchLink fieldCode="IS" term="%2200016322%22">00016322 </searchLink><i>NLM ISO Abbreviation: </i>Acta Neuropathol <i>Subsets: </i>MEDLINE |
| PLink | https://search.ebscohost.com/login.aspx?direct=true&site=eds-live&db=mdl&AN=38918213 |
| RecordInfo | BibRecord: BibEntity: Identifiers: – Type: doi Value: 10.1007/s00401-024-02755-5 Languages: – Code: eng Text: English PhysicalDescription: Pagination: StartPage: 107 Titles: – TitleFull: Xenografted human iPSC-derived neurons with the familial Alzheimer's disease APPV717I mutation reveal dysregulated transcriptome signatures linked to synaptic function and implicate LINGO2 as a disease signaling mediator. Type: main BibRelationships: HasContributorRelationships: – PersonEntity: Name: NameFull: Qu W – PersonEntity: Name: NameFull: Lam M – PersonEntity: Name: NameFull: McInvale JJ – PersonEntity: Name: NameFull: Mares JA – PersonEntity: Name: NameFull: Kwon S – PersonEntity: Name: NameFull: Humala N – PersonEntity: Name: NameFull: Mahajan A – PersonEntity: Name: NameFull: Nguyen T – PersonEntity: Name: NameFull: Jakubiak KA – PersonEntity: Name: NameFull: Mun JY – PersonEntity: Name: NameFull: Tedesco TG – PersonEntity: Name: NameFull: Al-Dalahmah O – PersonEntity: Name: NameFull: Hussaini SA – PersonEntity: Name: NameFull: Sproul AA – PersonEntity: Name: NameFull: Siegelin MD – PersonEntity: Name: NameFull: De Jager PL – PersonEntity: Name: NameFull: Canoll P – PersonEntity: Name: NameFull: Menon V – PersonEntity: Name: NameFull: Hargus G IsPartOfRelationships: – BibEntity: Dates: – D: 25 M: 06 Text: 2024 Jun 25 Type: published Y: 2024 Identifiers: – Type: issn-electronic Value: 1432-0533 Numbering: – Type: volume Value: 147 – Type: issue Value: 1 Titles: – TitleFull: Acta neuropathologica Type: main |
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