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Structural and mechanistic insights into a lysosomal membrane enzyme HGSNAT involved in Sanfilippo syndrome.

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Title: Structural and mechanistic insights into a lysosomal membrane enzyme HGSNAT involved in Sanfilippo syndrome.
Authors: Zhao B; Amgen Research, Department of Structural biology, South San Francisco, CA, USA., Cao Z; Amgen Research, Department of Inflammation, South San Francisco, CA, USA., Zheng Y; Amgen Research, Department of Discovery Protein Science, South San Francisco, CA, USA., Nguyen P; Department of Biochemistry and Biophysics, University of California San Francisco (UCSF) School of Medicine, San Francisco, CA, USA.; Laboratory for Genomics Research, UCSF School of Medicine, San Francisco, CA, USA., Bowen A; Department of Biochemistry and Biophysics, University of California San Francisco (UCSF) School of Medicine, San Francisco, CA, USA.; Adanate, Alameda, CA, USA., Edwards RH; Departments of Neurology and Physiology, UCSF School of Medicine, San Francisco, CA, USA., Stroud RM; Department of Biochemistry and Biophysics, University of California San Francisco (UCSF) School of Medicine, San Francisco, CA, USA., Zhou Y; Amgen Research, Department of Inflammation, South San Francisco, CA, USA., Van Lookeren Campagne M; Amgen Research, Department of Inflammation, South San Francisco, CA, USA., Li F; Amgen Research, Department of Structural biology, South San Francisco, CA, USA. fli05@amgen.com.
Source: Nature communications [Nat Commun] 2024 Jun 25; Vol. 15 (1), pp. 5388. Date of Electronic Publication: 2024 Jun 25.
Publication Type: Journal Article
Journal Info: Publisher: Nature Pub. Group Country of Publication: England NLM ID: 101528555 Publication Model: Electronic Cited Medium: Internet ISSN: 2041-1723 (Electronic) Linking ISSN: 20411723 NLM ISO Abbreviation: Nat Commun Subsets: MEDLINE
Database: MEDLINE Ultimate
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ISSN:2041-1723
DOI:10.1038/s41467-024-49614-1