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KCa channel targeting impairs DNA repair and invasiveness of patient-derived glioblastoma stem cells in culture and orthotopic mouse xenografts which only in part is predictable by KCa expression levels.

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Title: KCa channel targeting impairs DNA repair and invasiveness of patient-derived glioblastoma stem cells in culture and orthotopic mouse xenografts which only in part is predictable by KCa expression levels.
Authors: Ganser K; Department of Radiation Oncology, University Hospital of Tübingen, Tübingen, Germany., Stransky N; Department of Radiation Oncology, University Hospital of Tübingen, Tübingen, Germany.; Department of Pharmacology, Toxicology and Clinical Pharmacy, Institute of Pharmacy, University of Tübingen, Tübingen, Germany., Abed T; Department of Radiation Oncology, University Hospital of Tübingen, Tübingen, Germany., Quintanilla-Martinez L; Institute of Pathology and Neuropathology, Comprehensive Cancer Center, Eberhard Karls University of Tübingen, Tübingen, Germany.; Cluster of Excellence iFIT (EXC 2180), Image-Guided and Functionally Instructed Tumor Therapies, Eberhard Karls University, Tuebingen, Germany., Gonzalez-Menendez I; Institute of Pathology and Neuropathology, Comprehensive Cancer Center, Eberhard Karls University of Tübingen, Tübingen, Germany.; Cluster of Excellence iFIT (EXC 2180), Image-Guided and Functionally Instructed Tumor Therapies, Eberhard Karls University, Tuebingen, Germany., Naumann U; Molecular Neurooncology, Hertie Institute for Clinical Brain Research and Center Neurology, University of Tübingen, Tübingen, Germany., Koch P; Department of Pharmaceutical/Medicinal Chemistry II, Institute of Pharmacy, University of Regensburg, Regensburg, Germany., Krueger M; Department of Preclinical Imaging and Radiopharmacy, Werner Siemens Imaging Center, University of Tübingen, Tübingen, Germany., Ruth P; Department of Pharmacology, Toxicology and Clinical Pharmacy, Institute of Pharmacy, University of Tübingen, Tübingen, Germany., Huber SM; Department of Radiation Oncology, University Hospital of Tübingen, Tübingen, Germany., Eckert F; Department of Radiation Oncology, University Hospital of Tübingen, Tübingen, Germany.; Department of Radiation Oncology, Medical University Vienna, AKH, Comprehensive Cancer Center, Vienna, Austria.
Source: International journal of cancer [Int J Cancer] 2024 Nov 15; Vol. 155 (10), pp. 1886-1901. Date of Electronic Publication: 2024 Jun 27.
Publication Type: Journal Article; Research Support, Non-U.S. Gov't
Journal Info: Publisher: Wiley-Liss Country of Publication: United States NLM ID: 0042124 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1097-0215 (Electronic) Linking ISSN: 00207136 NLM ISO Abbreviation: Int J Cancer Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: K<subscript>Ca</subscript> channel targeting impairs DNA repair and invasiveness of patient-derived glioblastoma stem cells in culture and orthotopic mouse xenografts which only in part is predictable by K<subscript>Ca</subscript> expression levels.
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  Data: <searchLink fieldCode="AU" term="%22Ganser+K%22">Ganser K</searchLink>; Department of Radiation Oncology, University Hospital of Tübingen, Tübingen, Germany.<br /><searchLink fieldCode="AU" term="%22Stransky+N%22">Stransky N</searchLink>; Department of Radiation Oncology, University Hospital of Tübingen, Tübingen, Germany.; Department of Pharmacology, Toxicology and Clinical Pharmacy, Institute of Pharmacy, University of Tübingen, Tübingen, Germany.<br /><searchLink fieldCode="AU" term="%22Abed+T%22">Abed T</searchLink>; Department of Radiation Oncology, University Hospital of Tübingen, Tübingen, Germany.<br /><searchLink fieldCode="AU" term="%22Quintanilla-Martinez+L%22">Quintanilla-Martinez L</searchLink>; Institute of Pathology and Neuropathology, Comprehensive Cancer Center, Eberhard Karls University of Tübingen, Tübingen, Germany.; Cluster of Excellence iFIT (EXC 2180), Image-Guided and Functionally Instructed Tumor Therapies, Eberhard Karls University, Tuebingen, Germany.<br /><searchLink fieldCode="AU" term="%22Gonzalez-Menendez+I%22">Gonzalez-Menendez I</searchLink>; Institute of Pathology and Neuropathology, Comprehensive Cancer Center, Eberhard Karls University of Tübingen, Tübingen, Germany.; Cluster of Excellence iFIT (EXC 2180), Image-Guided and Functionally Instructed Tumor Therapies, Eberhard Karls University, Tuebingen, Germany.<br /><searchLink fieldCode="AU" term="%22Naumann+U%22">Naumann U</searchLink>; Molecular Neurooncology, Hertie Institute for Clinical Brain Research and Center Neurology, University of Tübingen, Tübingen, Germany.<br /><searchLink fieldCode="AU" term="%22Koch+P%22">Koch P</searchLink>; Department of Pharmaceutical/Medicinal Chemistry II, Institute of Pharmacy, University of Regensburg, Regensburg, Germany.<br /><searchLink fieldCode="AU" term="%22Krueger+M%22">Krueger M</searchLink>; Department of Preclinical Imaging and Radiopharmacy, Werner Siemens Imaging Center, University of Tübingen, Tübingen, Germany.<br /><searchLink fieldCode="AU" term="%22Ruth+P%22">Ruth P</searchLink>; Department of Pharmacology, Toxicology and Clinical Pharmacy, Institute of Pharmacy, University of Tübingen, Tübingen, Germany.<br /><searchLink fieldCode="AU" term="%22Huber+SM%22">Huber SM</searchLink>; Department of Radiation Oncology, University Hospital of Tübingen, Tübingen, Germany.<br /><searchLink fieldCode="AU" term="%22Eckert+F%22">Eckert F</searchLink>; Department of Radiation Oncology, University Hospital of Tübingen, Tübingen, Germany.; Department of Radiation Oncology, Medical University Vienna, AKH, Comprehensive Cancer Center, Vienna, Austria.
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  Data: <searchLink fieldCode="JN" term="%220042124%22">International journal of cancer</searchLink> [Int J Cancer] 2024 Nov 15; Vol. 155 (10), pp. 1886-1901. <i>Date of Electronic Publication: </i>2024 Jun 27.
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              Text: 2024 Nov 15
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