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Cabozantinib and nivolumab with or without live bacterial supplementation in metastatic renal cell carcinoma: a randomized phase 1 trial.

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Title: Cabozantinib and nivolumab with or without live bacterial supplementation in metastatic renal cell carcinoma: a randomized phase 1 trial.
Authors: Ebrahimi H; Department of Medical Oncology, City of Hope Comprehensive Cancer Center, Duarte, CA, USA., Dizman N; Department of Medical Oncology, City of Hope Comprehensive Cancer Center, Duarte, CA, USA.; MD Anderson Cancer Center, Houston, TX, USA., Meza L; Department of Medical Oncology, City of Hope Comprehensive Cancer Center, Duarte, CA, USA.; Yale University School of Medicine, New Haven, CT, USA., Malhotra J; Department of Medical Oncology, City of Hope Comprehensive Cancer Center, Duarte, CA, USA., Li X; Department of Medical Oncology, City of Hope Comprehensive Cancer Center, Duarte, CA, USA., Dorff T; Department of Medical Oncology, City of Hope Comprehensive Cancer Center, Duarte, CA, USA., Frankel P; Department of Biostatistics, City of Hope Comprehensive Cancer Center, Duarte, CA, USA., Llamas-Quitiquit M; Department of Medical Oncology, City of Hope Comprehensive Cancer Center, Duarte, CA, USA., Hsu J; Department of Medical Oncology, City of Hope Comprehensive Cancer Center, Duarte, CA, USA., Zengin ZB; Department of Medical Oncology, City of Hope Comprehensive Cancer Center, Duarte, CA, USA.; Yale University School of Medicine, New Haven, CT, USA., Alcantara M; Department of Immuno-Oncology, Beckman Research Institute, City of Hope Comprehensive Cancer Center, Duarte, CA, USA., Castro D; Department of Medical Oncology, City of Hope Comprehensive Cancer Center, Duarte, CA, USA., Mercier B; Department of Medical Oncology, City of Hope Comprehensive Cancer Center, Duarte, CA, USA., Chawla N; Department of Medical Oncology, City of Hope Comprehensive Cancer Center, Duarte, CA, USA., Chehrazi-Raffle A; Department of Medical Oncology, City of Hope Comprehensive Cancer Center, Duarte, CA, USA., Barragan-Carrillo R; Department of Medical Oncology, City of Hope Comprehensive Cancer Center, Duarte, CA, USA., Jaime-Casas S; Department of Medical Oncology, City of Hope Comprehensive Cancer Center, Duarte, CA, USA., Govindarajan A; Department of Medical Oncology, City of Hope Comprehensive Cancer Center, Duarte, CA, USA., Gillece J; Translational Genomics Research Institute (TGen), Phoenix, AZ, USA., Trent J; Translational Genomics Research Institute (TGen), Phoenix, AZ, USA., Lee PP; Department of Immuno-Oncology, Beckman Research Institute, City of Hope Comprehensive Cancer Center, Duarte, CA, USA., Parks TP; Osel, Inc., Mountain View, CA, USA., Takahashi M; Miyarisan Pharmaceutical Co., Ltd, Tokyo, Japan., Hayashi A; Miyarisan Pharmaceutical Co., Ltd, Tokyo, Japan., Kortylewski M; Department of Immuno-Oncology, Beckman Research Institute, City of Hope Comprehensive Cancer Center, Duarte, CA, USA., Caporaso JG; Translational Genomics Research Institute (TGen), Flagstaff, AZ, USA., Lee K; Translational Genomics Research Institute (TGen), Flagstaff, AZ, USA., Tripathi A; Department of Medical Oncology, City of Hope Comprehensive Cancer Center, Duarte, CA, USA. atripathi@coh.org., Pal SK; Department of Medical Oncology, City of Hope Comprehensive Cancer Center, Duarte, CA, USA. spal@coh.org.
Source: Nature medicine [Nat Med] 2024 Sep; Vol. 30 (9), pp. 2576-2585. Date of Electronic Publication: 2024 Jun 28.
Publication Type: Journal Article; Randomized Controlled Trial; Clinical Trial, Phase I
Journal Info: Publisher: Nature Publishing Company Country of Publication: United States NLM ID: 9502015 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1546-170X (Electronic) Linking ISSN: 10788956 NLM ISO Abbreviation: Nat Med Subsets: MEDLINE
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  Data: Cabozantinib and nivolumab with or without live bacterial supplementation in metastatic renal cell carcinoma: a randomized phase 1 trial.
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Department of Medical Oncology, City of Hope Comprehensive Cancer Center, Duarte, CA, USA.<br /><searchLink fieldCode="AU" term="%22Frankel+P%22">Frankel P</searchLink>; Department of Biostatistics, City of Hope Comprehensive Cancer Center, Duarte, CA, USA.<br /><searchLink fieldCode="AU" term="%22Llamas-Quitiquit+M%22">Llamas-Quitiquit M</searchLink>; Department of Medical Oncology, City of Hope Comprehensive Cancer Center, Duarte, CA, USA.<br /><searchLink fieldCode="AU" term="%22Hsu+J%22">Hsu J</searchLink>; Department of Medical Oncology, City of Hope Comprehensive Cancer Center, Duarte, CA, USA.<br /><searchLink fieldCode="AU" term="%22Zengin+ZB%22">Zengin ZB</searchLink>; Department of Medical Oncology, City of Hope Comprehensive Cancer Center, Duarte, CA, USA.; Yale University School of Medicine, New Haven, CT, USA.<br /><searchLink fieldCode="AU" term="%22Alcantara+M%22">Alcantara M</searchLink>; Department of Immuno-Oncology, Beckman Research Institute, City of Hope Comprehensive Cancer Center, Duarte, CA, USA.<br /><searchLink fieldCode="AU" term="%22Castro+D%22">Castro D</searchLink>; Department of Medical Oncology, City of Hope Comprehensive Cancer Center, Duarte, CA, USA.<br /><searchLink fieldCode="AU" term="%22Mercier+B%22">Mercier B</searchLink>; Department of Medical Oncology, City of Hope Comprehensive Cancer Center, Duarte, CA, USA.<br /><searchLink fieldCode="AU" term="%22Chawla+N%22">Chawla N</searchLink>; Department of Medical Oncology, City of Hope Comprehensive Cancer Center, Duarte, CA, USA.<br /><searchLink fieldCode="AU" term="%22Chehrazi-Raffle+A%22">Chehrazi-Raffle A</searchLink>; Department of Medical Oncology, City of Hope Comprehensive Cancer Center, Duarte, CA, USA.<br /><searchLink fieldCode="AU" term="%22Barragan-Carrillo+R%22">Barragan-Carrillo R</searchLink>; Department of Medical Oncology, City of Hope Comprehensive Cancer Center, Duarte, CA, USA.<br /><searchLink fieldCode="AU" term="%22Jaime-Casas+S%22">Jaime-Casas S</searchLink>; Department of Medical Oncology, City of Hope Comprehensive Cancer Center, Duarte, CA, USA.<br /><searchLink fieldCode="AU" term="%22Govindarajan+A%22">Govindarajan A</searchLink>; Department of Medical Oncology, City of Hope Comprehensive Cancer Center, Duarte, CA, USA.<br /><searchLink fieldCode="AU" term="%22Gillece+J%22">Gillece J</searchLink>; Translational Genomics Research Institute (TGen), Phoenix, AZ, USA.<br /><searchLink fieldCode="AU" term="%22Trent+J%22">Trent J</searchLink>; Translational Genomics Research Institute (TGen), Phoenix, AZ, USA.<br /><searchLink fieldCode="AU" term="%22Lee+PP%22">Lee PP</searchLink>; Department of Immuno-Oncology, Beckman Research Institute, City of Hope Comprehensive Cancer Center, Duarte, CA, USA.<br /><searchLink fieldCode="AU" term="%22Parks+TP%22">Parks TP</searchLink>; Osel, Inc., Mountain View, CA, USA.<br /><searchLink fieldCode="AU" term="%22Takahashi+M%22">Takahashi M</searchLink>; Miyarisan Pharmaceutical Co., Ltd, Tokyo, Japan.<br /><searchLink fieldCode="AU" term="%22Hayashi+A%22">Hayashi A</searchLink>; Miyarisan Pharmaceutical Co., Ltd, Tokyo, Japan.<br /><searchLink fieldCode="AU" term="%22Kortylewski+M%22">Kortylewski M</searchLink>; Department of Immuno-Oncology, Beckman Research Institute, City of Hope Comprehensive Cancer Center, Duarte, CA, USA.<br /><searchLink fieldCode="AU" term="%22Caporaso+JG%22">Caporaso JG</searchLink>; Translational Genomics Research Institute (TGen), Flagstaff, AZ, USA.<br /><searchLink fieldCode="AU" term="%22Lee+K%22">Lee K</searchLink>; Translational Genomics Research Institute (TGen), Flagstaff, AZ, USA.<br /><searchLink fieldCode="AU" term="%22Tripathi+A%22">Tripathi A</searchLink>; Department of Medical Oncology, City of Hope Comprehensive Cancer Center, Duarte, CA, USA. atripathi@coh.org.<br /><searchLink fieldCode="AU" term="%22Pal+SK%22">Pal SK</searchLink>; Department of Medical Oncology, City of Hope Comprehensive Cancer Center, Duarte, CA, USA. spal@coh.org.
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  Data: <searchLink fieldCode="JN" term="%229502015%22">Nature medicine</searchLink> [Nat Med] 2024 Sep; Vol. 30 (9), pp. 2576-2585. <i>Date of Electronic Publication: </i>2024 Jun 28.
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