Structure and function of the SIT1 proline transporter in complex with the COVID-19 receptor ACE2.

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Title: Structure and function of the SIT1 proline transporter in complex with the COVID-19 receptor ACE2.
Authors: Li HZ; Centre for Medicines Discovery, Nuffield Department of Medicine, University of Oxford, Oxford, UK., Pike ACW; Centre for Medicines Discovery, Nuffield Department of Medicine, University of Oxford, Oxford, UK., Lotsaris I; Molecular Biomedicine Theme, School of Medical Sciences, University of Sydney, Sydney, NSW, Australia., Chi G; Centre for Medicines Discovery, Nuffield Department of Medicine, University of Oxford, Oxford, UK., Hansen JS; Centre for Medicines Discovery, Nuffield Department of Medicine, University of Oxford, Oxford, UK., Lee SC; School of Biosciences, University of Birmingham, Birmingham, UK., Rödström KEJ; Centre for Medicines Discovery, Nuffield Department of Medicine, University of Oxford, Oxford, UK., Bushell SR; Centre for Medicines Discovery, Nuffield Department of Medicine, University of Oxford, Oxford, UK., Speedman D; Centre for Medicines Discovery, Nuffield Department of Medicine, University of Oxford, Oxford, UK., Evans A; Centre for Medicines Discovery, Nuffield Department of Medicine, University of Oxford, Oxford, UK., Wang D; Centre for Medicines Discovery, Nuffield Department of Medicine, University of Oxford, Oxford, UK., He D; Centre for Medicines Discovery, Nuffield Department of Medicine, University of Oxford, Oxford, UK., Shrestha L; Centre for Medicines Discovery, Nuffield Department of Medicine, University of Oxford, Oxford, UK., Nasrallah C; Centre for Medicines Discovery, Nuffield Department of Medicine, University of Oxford, Oxford, UK., Burgess-Brown NA; Centre for Medicines Discovery, Nuffield Department of Medicine, University of Oxford, Oxford, UK., Vandenberg RJ; Molecular Biomedicine Theme, School of Medical Sciences, University of Sydney, Sydney, NSW, Australia. robert.vandenberg@sydney.edu.au., Dafforn TR; School of Biosciences, University of Birmingham, Birmingham, UK. t.r.dafforn@bham.ac.uk., Carpenter EP; Centre for Medicines Discovery, Nuffield Department of Medicine, University of Oxford, Oxford, UK. lizcarpen1@gmail.com., Sauer DB; Centre for Medicines Discovery, Nuffield Department of Medicine, University of Oxford, Oxford, UK. david.sauer@cmd.ox.ac.uk.
Source: Nature communications [Nat Commun] 2024 Jun 29; Vol. 15 (1), pp. 5503. Date of Electronic Publication: 2024 Jun 29.
Publication Type: Journal Article
Journal Info: Publisher: Nature Pub. Group Country of Publication: England NLM ID: 101528555 Publication Model: Electronic Cited Medium: Internet ISSN: 2041-1723 (Electronic) Linking ISSN: 20411723 NLM ISO Abbreviation: Nat Commun Subsets: MEDLINE
Database: MEDLINE Ultimate
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ISSN:2041-1723
DOI:10.1038/s41467-024-48921-x