Altered desensitization and internalization patterns of rodent versus human glucose-dependent insulinotropic polypeptide (GIP) receptors. An important drug discovery challenge.
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| Title: | Altered desensitization and internalization patterns of rodent versus human glucose-dependent insulinotropic polypeptide (GIP) receptors. An important drug discovery challenge. |
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| Authors: | Gasbjerg LS; Department of Biomedical Sciences, Faculty of Healthy and Medical Sciences, University of Copenhagen, Copenhagen, Denmark., Rasmussen RS; Department of Biomedical Sciences, Faculty of Healthy and Medical Sciences, University of Copenhagen, Copenhagen, Denmark., Dragan A; Department of Biomedical Sciences, Faculty of Healthy and Medical Sciences, University of Copenhagen, Copenhagen, Denmark., Lindquist P; Department of Biomedical Sciences, Faculty of Healthy and Medical Sciences, University of Copenhagen, Copenhagen, Denmark., Melchiorsen JU; Department of Biomedical Sciences, Faculty of Healthy and Medical Sciences, University of Copenhagen, Copenhagen, Denmark., Stepniewski TM; Research Programme on Biomedical Informatics (GRIB), Hospital del Mar Research Institute and Pompeu Fabra University, Barcelona, Spain.; InterAx Biotech AG, Villigen, Switzerland.; Biological and Chemical Research Centre, Faculty of Chemistry, University of Warsaw, Warsaw, Poland., Schiellerup S; Department of Biomedical Sciences, Faculty of Healthy and Medical Sciences, University of Copenhagen, Copenhagen, Denmark., Tordrup EK; Department of Biomedical Sciences, Faculty of Healthy and Medical Sciences, University of Copenhagen, Copenhagen, Denmark., Gadgaard S; Department of Biomedical Sciences, Faculty of Healthy and Medical Sciences, University of Copenhagen, Copenhagen, Denmark.; Bainan Biotech, Copenhagen, Denmark., Kizilkaya HS; Department of Biomedical Sciences, Faculty of Healthy and Medical Sciences, University of Copenhagen, Copenhagen, Denmark., Willems S; Department of Physiology and Pharmacology, Karolinska Institutet, Stockholm, Sweden., Zhong Y; Department of Physiology and Pharmacology, Karolinska Institutet, Stockholm, Sweden.; College of Pharmaceutical Sciences, Zhejiang University, Hangzhou, China., Wang Y; College of Pharmaceutical Sciences, Zhejiang University, Hangzhou, China.; Innovation Institute for Artificial Intelligence in Medicine of Zhejiang University, Hangzhou, China.; National Key Laboratory of Chinese Medicine Modernization, Innovation Center of Yangtze River Delta, Zhejiang University, Jiaxing, China., Wright SC; Department of Physiology and Pharmacology, Karolinska Institutet, Stockholm, Sweden., Lauschke VM; Department of Physiology and Pharmacology, Karolinska Institutet, Stockholm, Sweden.; Dr Margarete Fischer-Bosch Institute of Clinical Pharmacology, Stuttgart, Germany.; University of Tübingen, Tübingen, Germany., Hartmann B; Department of Biomedical Sciences, Faculty of Healthy and Medical Sciences, University of Copenhagen, Copenhagen, Denmark., Holst JJ; Department of Biomedical Sciences, Faculty of Healthy and Medical Sciences, University of Copenhagen, Copenhagen, Denmark.; Novo Nordisk Center for Basic Metabolic Research, Faculty of Healthy and Medical Sciences, University of Copenhagen, Copenhagen, Denmark., Selent J; Research Programme on Biomedical Informatics (GRIB), Hospital del Mar Research Institute and Pompeu Fabra University, Barcelona, Spain., Rosenkilde MM; Department of Biomedical Sciences, Faculty of Healthy and Medical Sciences, University of Copenhagen, Copenhagen, Denmark. |
| Source: | British journal of pharmacology [Br J Pharmacol] 2025 Jul; Vol. 182 (14), pp. 3353-3370. Date of Electronic Publication: 2024 Jul 01. |
| Publication Type: | Journal Article; Comparative Study |
| Journal Info: | Publisher: Wiley Country of Publication: England NLM ID: 7502536 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1476-5381 (Electronic) Linking ISSN: 00071188 NLM ISO Abbreviation: Br J Pharmacol Subsets: MEDLINE |
| Database: | MEDLINE Ultimate |
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| ISSN: | 1476-5381 |
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| DOI: | 10.1111/bph.16478 |
