PI3Kγ in B cells promotes antibody responses and generation of antibody-secreting cells.

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Title: PI3Kγ in B cells promotes antibody responses and generation of antibody-secreting cells.
Authors: Lanahan SM; Department of Immunobiology, Yale University School of Medicine, New Haven, CT, USA., Yang L; Department of Immunobiology, Yale University School of Medicine, New Haven, CT, USA., Jones KM; Department of Immunobiology, Yale University School of Medicine, New Haven, CT, USA., Qi Z; Department of Immunobiology, Yale University School of Medicine, New Haven, CT, USA., Cabrera EC; Division of Immunology and Allergy, Children's Hospital of Philadelphia, Philadelphia, PA, USA., Cominsky LY; Immunology Graduate Group, Perelman School of Medicine, Philadelphia, PA, USA., Ramaswamy A; Department of Immunobiology, Yale University School of Medicine, New Haven, CT, USA., Barmada A; Department of Immunobiology, Yale University School of Medicine, New Haven, CT, USA., Gabernet G; Department of Pathology, Yale University School of Medicine, New Haven, CT, USA., Uthaya Kumar DB; Department of Immunobiology, Yale University School of Medicine, New Haven, CT, USA., Xu L; Department of Immunobiology, Yale University School of Medicine, New Haven, CT, USA., Shan P; Department of Immunobiology, Yale University School of Medicine, New Haven, CT, USA., Wymann MP; Department of Biomedicine, University of Basel, Basel, Switzerland., Kleinstein SH; Department of Immunobiology, Yale University School of Medicine, New Haven, CT, USA.; Department of Pathology, Yale University School of Medicine, New Haven, CT, USA.; Program in Computational Biology and Bioinformatics, Yale University, New Haven, CT, USA., Rao VK; Primary Immunodeficiency Clinic, Laboratory of Clinical Immunology and Microbiology, NIAID, NIH, Bethesda, MD, USA., Mustillo P; Division of Allergy and Immunology, Department of Pediatrics, Nationwide Children's Hospital, Columbus, OH, USA., Romberg N; Division of Immunology and Allergy, Children's Hospital of Philadelphia, Philadelphia, PA, USA.; Department of Pediatrics, Perelman School of Medicine, Philadelphia, PA, USA., Abraham RS; Department of Pathology and Laboratory Medicine, Nationwide Children's Hospital, Columbus, OH, USA., Lucas CL; Department of Immunobiology, Yale University School of Medicine, New Haven, CT, USA. Carrie.Lucas@yale.edu.
Source: Nature immunology [Nat Immunol] 2024 Aug; Vol. 25 (8), pp. 1422-1431. Date of Electronic Publication: 2024 Jul 03.
Publication Type: Journal Article
Journal Info: Publisher: Nature America Inc Country of Publication: United States NLM ID: 100941354 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1529-2916 (Electronic) Linking ISSN: 15292908 NLM ISO Abbreviation: Nat Immunol Subsets: MEDLINE
Database: MEDLINE Ultimate
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ISSN:1529-2916
DOI:10.1038/s41590-024-01890-1