A µ-opioid receptor modulator that works cooperatively with naloxone.

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Title: A µ-opioid receptor modulator that works cooperatively with naloxone.
Authors: O'Brien ES; Department of Molecular and Cellular Physiology, Stanford University School of Medicine, Stanford, CA, USA., Rangari VA; Center for Clinical Pharmacology, University of Health Sciences and Pharmacy at St Louis and Washington University School of Medicine, St Louis, MO, USA., El Daibani A; Center for Clinical Pharmacology, University of Health Sciences and Pharmacy at St Louis and Washington University School of Medicine, St Louis, MO, USA., Eans SO; Department of Pharmacodynamics, University of Florida, Gainesville, FL, USA., Hammond HR; Department of Pharmacodynamics, University of Florida, Gainesville, FL, USA., White E; Department of Molecular and Cellular Physiology, Stanford University School of Medicine, Stanford, CA, USA., Wang H; Department of Molecular and Cellular Physiology, Stanford University School of Medicine, Stanford, CA, USA., Shiimura Y; Department of Molecular and Cellular Physiology, Stanford University School of Medicine, Stanford, CA, USA.; Division of Molecular Genetics, Institute of Life Science, Kurume University, Fukuoka, Japan., Krishna Kumar K; Department of Molecular and Cellular Physiology, Stanford University School of Medicine, Stanford, CA, USA., Jiang Q; Center for Clinical Pharmacology, University of Health Sciences and Pharmacy at St Louis and Washington University School of Medicine, St Louis, MO, USA., Appourchaux K; Center for Clinical Pharmacology, University of Health Sciences and Pharmacy at St Louis and Washington University School of Medicine, St Louis, MO, USA., Huang W; Department of Molecular and Cellular Physiology, Stanford University School of Medicine, Stanford, CA, USA., Zhang C; Division of CryoEM and Bioimaging, SSRL, SLAC National Acceleration Laboratory, Menlo Park, CA, USA., Kennedy BJ; Lotus Separations, Princeton University, Princeton, NJ, USA., Mathiesen JM; Department of Drug Design and Pharmacology, University of Copenhagen, Copenhagen, Denmark., Che T; Center for Clinical Pharmacology, University of Health Sciences and Pharmacy at St Louis and Washington University School of Medicine, St Louis, MO, USA., McLaughlin JP; Department of Pharmacodynamics, University of Florida, Gainesville, FL, USA. jpmclaughlin@ufl.edu., Majumdar S; Center for Clinical Pharmacology, University of Health Sciences and Pharmacy at St Louis and Washington University School of Medicine, St Louis, MO, USA. susrutam@wustl.edu., Kobilka BK; Department of Molecular and Cellular Physiology, Stanford University School of Medicine, Stanford, CA, USA. kobilka@stanford.edu.
Source: Nature [Nature] 2024 Jul; Vol. 631 (8021), pp. 686-693. Date of Electronic Publication: 2024 Jul 03.
Publication Type: Journal Article; Research Support, N.I.H., Extramural
Journal Info: Publisher: Nature Publishing Group Country of Publication: England NLM ID: 0410462 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1476-4687 (Electronic) Linking ISSN: 00280836 NLM ISO Abbreviation: Nature Subsets: MEDLINE
Database: MEDLINE Ultimate
Description
ISSN:1476-4687
DOI:10.1038/s41586-024-07587-7