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Assessing the interplay between off-target promiscuity, cytotoxicity, and tolerability in rodents to improve the safety profile of novel anti-malarial plasmepsin X inhibitors.

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Title: Assessing the interplay between off-target promiscuity, cytotoxicity, and tolerability in rodents to improve the safety profile of novel anti-malarial plasmepsin X inhibitors.
Authors: Gerets HHJ; UCB Biopharma SRL, 1420 Braine-l'Alleud, Belgium., Delaunois A; UCB Biopharma SRL, 1420 Braine-l'Alleud, Belgium., Cardenas A; UCB Biopharma SRL, 1420 Braine-l'Alleud, Belgium., Class R; UCB Biopharma SRL, 1420 Braine-l'Alleud, Belgium., Fleurance R; UCB Biopharma SRL, 1420 Braine-l'Alleud, Belgium., de Haro T; UCB Biopharma SRL, 1420 Braine-l'Alleud, Belgium., Laleu B; MMV Medicines for Malaria Venture, ICC, 1215 Geneva, Switzerland., Lowe MA; UK Branch of UCB Pharma, SL1 3WE Slough, United Kingdom., Rosseels ML; UCB Biopharma SRL, 1420 Braine-l'Alleud, Belgium., Valentin JP; UCB Biopharma SRL, 1420 Braine-l'Alleud, Belgium.
Source: Toxicological sciences : an official journal of the Society of Toxicology [Toxicol Sci] 2024 Oct 01; Vol. 201 (2), pp. 311-320.
Publication Type: Journal Article
Journal Info: Publisher: Oxford University Press Country of Publication: United States NLM ID: 9805461 Publication Model: Print Cited Medium: Internet ISSN: 1096-0929 (Electronic) Linking ISSN: 10960929 NLM ISO Abbreviation: Toxicol Sci Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: <searchLink fieldCode="AU" term="%22Gerets+HHJ%22">Gerets HHJ</searchLink>; UCB Biopharma SRL, 1420 Braine-l'Alleud, Belgium.<br /><searchLink fieldCode="AU" term="%22Delaunois+A%22">Delaunois A</searchLink>; UCB Biopharma SRL, 1420 Braine-l'Alleud, Belgium.<br /><searchLink fieldCode="AU" term="%22Cardenas+A%22">Cardenas A</searchLink>; UCB Biopharma SRL, 1420 Braine-l'Alleud, Belgium.<br /><searchLink fieldCode="AU" term="%22Class+R%22">Class R</searchLink>; UCB Biopharma SRL, 1420 Braine-l'Alleud, Belgium.<br /><searchLink fieldCode="AU" term="%22Fleurance+R%22">Fleurance R</searchLink>; UCB Biopharma SRL, 1420 Braine-l'Alleud, Belgium.<br /><searchLink fieldCode="AU" term="%22de+Haro+T%22">de Haro T</searchLink>; UCB Biopharma SRL, 1420 Braine-l'Alleud, Belgium.<br /><searchLink fieldCode="AU" term="%22Laleu+B%22">Laleu B</searchLink>; MMV Medicines for Malaria Venture, ICC, 1215 Geneva, Switzerland.<br /><searchLink fieldCode="AU" term="%22Lowe+MA%22">Lowe MA</searchLink>; UK Branch of UCB Pharma, SL1 3WE Slough, United Kingdom.<br /><searchLink fieldCode="AU" term="%22Rosseels+ML%22">Rosseels ML</searchLink>; UCB Biopharma SRL, 1420 Braine-l'Alleud, Belgium.<br /><searchLink fieldCode="AU" term="%22Valentin+JP%22">Valentin JP</searchLink>; UCB Biopharma SRL, 1420 Braine-l'Alleud, Belgium.
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  Data: <i>Publisher: </i><searchLink fieldCode="PB" term="%22Oxford+University+Press%22">Oxford University Press </searchLink><i>Country of Publication: </i>United States <i>NLM ID: </i>9805461 <i>Publication Model: </i>Print <i>Cited Medium: </i>Internet <i>ISSN: </i>1096-0929 (Electronic) <i>Linking ISSN: </i><searchLink fieldCode="IS" term="%2210960929%22">10960929 </searchLink><i>NLM ISO Abbreviation: </i>Toxicol Sci <i>Subsets: </i>MEDLINE
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              Text: 2024 Oct 01
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