Adjunctive therapy with an oral H2S donor provides additional therapeutic benefit beyond SGLT2 inhibition in cardiometabolic heart failure with preserved ejection fraction.

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Title: Adjunctive therapy with an oral H2S donor provides additional therapeutic benefit beyond SGLT2 inhibition in cardiometabolic heart failure with preserved ejection fraction.
Authors: Doiron JE; Department of Pharmacology and Experimental Therapeutics, LSU Health Sciences Center, New Orleans, Louisiana, USA., Xia H; Department of Pharmacology and Experimental Therapeutics, LSU Health Sciences Center, New Orleans, Louisiana, USA.; Cardiovascular Center of Excellence, LSU Health Sciences Center, New Orleans, Louisiana, USA., Yu X; Department of Cardiac Surgery, Smidt Heart Institute, Cedars-Sinai Medical Center, Los Angeles, California, USA., Nevins AR; Department of Cardiac Surgery, Smidt Heart Institute, Cedars-Sinai Medical Center, Los Angeles, California, USA., LaPenna KB; Department of Pharmacology and Experimental Therapeutics, LSU Health Sciences Center, New Orleans, Louisiana, USA., Sharp TE 3rd; Molecular Pharmacology and Physiology, University of South Florida, Tampa, Florida, USA., Goodchild TT; Department of Cardiac Surgery, Smidt Heart Institute, Cedars-Sinai Medical Center, Los Angeles, California, USA., Allerton TD; Pennington Biomedical Research Center, Baton Rouge, Louisiana, USA., Elgazzaz M; Department of Pharmacology and Experimental Therapeutics, LSU Health Sciences Center, New Orleans, Louisiana, USA.; Cardiovascular Center of Excellence, LSU Health Sciences Center, New Orleans, Louisiana, USA., Lazartigues E; Department of Pharmacology and Experimental Therapeutics, LSU Health Sciences Center, New Orleans, Louisiana, USA.; Cardiovascular Center of Excellence, LSU Health Sciences Center, New Orleans, Louisiana, USA., Shah SJ; Feinberg School of Medicine, Northwestern University Medicine, Chicago, Illinois, USA., Li Z; Department of Cardiac Surgery, Smidt Heart Institute, Cedars-Sinai Medical Center, Los Angeles, California, USA., Lefer DJ; Department of Cardiac Surgery, Smidt Heart Institute, Cedars-Sinai Medical Center, Los Angeles, California, USA.
Source: British journal of pharmacology [Br J Pharmacol] 2024 Nov; Vol. 181 (21), pp. 4294-4310. Date of Electronic Publication: 2024 Jul 09.
Publication Type: Journal Article
Journal Info: Publisher: Wiley Country of Publication: England NLM ID: 7502536 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1476-5381 (Electronic) Linking ISSN: 00071188 NLM ISO Abbreviation: Br J Pharmacol Subsets: MEDLINE
Database: MEDLINE Ultimate
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Description
ISSN:1476-5381
DOI:10.1111/bph.16493