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Adjunctive therapy with an oral H2S donor provides additional therapeutic benefit beyond SGLT2 inhibition in cardiometabolic heart failure with preserved ejection fraction.

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Title: Adjunctive therapy with an oral H2S donor provides additional therapeutic benefit beyond SGLT2 inhibition in cardiometabolic heart failure with preserved ejection fraction.
Authors: Doiron JE; Department of Pharmacology and Experimental Therapeutics, LSU Health Sciences Center, New Orleans, Louisiana, USA., Xia H; Department of Pharmacology and Experimental Therapeutics, LSU Health Sciences Center, New Orleans, Louisiana, USA.; Cardiovascular Center of Excellence, LSU Health Sciences Center, New Orleans, Louisiana, USA., Yu X; Department of Cardiac Surgery, Smidt Heart Institute, Cedars-Sinai Medical Center, Los Angeles, California, USA., Nevins AR; Department of Cardiac Surgery, Smidt Heart Institute, Cedars-Sinai Medical Center, Los Angeles, California, USA., LaPenna KB; Department of Pharmacology and Experimental Therapeutics, LSU Health Sciences Center, New Orleans, Louisiana, USA., Sharp TE 3rd; Molecular Pharmacology and Physiology, University of South Florida, Tampa, Florida, USA., Goodchild TT; Department of Cardiac Surgery, Smidt Heart Institute, Cedars-Sinai Medical Center, Los Angeles, California, USA., Allerton TD; Pennington Biomedical Research Center, Baton Rouge, Louisiana, USA., Elgazzaz M; Department of Pharmacology and Experimental Therapeutics, LSU Health Sciences Center, New Orleans, Louisiana, USA.; Cardiovascular Center of Excellence, LSU Health Sciences Center, New Orleans, Louisiana, USA., Lazartigues E; Department of Pharmacology and Experimental Therapeutics, LSU Health Sciences Center, New Orleans, Louisiana, USA.; Cardiovascular Center of Excellence, LSU Health Sciences Center, New Orleans, Louisiana, USA., Shah SJ; Feinberg School of Medicine, Northwestern University Medicine, Chicago, Illinois, USA., Li Z; Department of Cardiac Surgery, Smidt Heart Institute, Cedars-Sinai Medical Center, Los Angeles, California, USA., Lefer DJ; Department of Cardiac Surgery, Smidt Heart Institute, Cedars-Sinai Medical Center, Los Angeles, California, USA.
Source: British journal of pharmacology [Br J Pharmacol] 2024 Nov; Vol. 181 (21), pp. 4294-4310. Date of Electronic Publication: 2024 Jul 09.
Publication Type: Journal Article
Journal Info: Publisher: Wiley Country of Publication: England NLM ID: 7502536 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1476-5381 (Electronic) Linking ISSN: 00071188 NLM ISO Abbreviation: Br J Pharmacol Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: Adjunctive therapy with an oral H<subscript>2</subscript>S donor provides additional therapeutic benefit beyond SGLT2 inhibition in cardiometabolic heart failure with preserved ejection fraction.
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  Data: <searchLink fieldCode="AU" term="%22Doiron+JE%22">Doiron JE</searchLink>; Department of Pharmacology and Experimental Therapeutics, LSU Health Sciences Center, New Orleans, Louisiana, USA.<br /><searchLink fieldCode="AU" term="%22Xia+H%22">Xia H</searchLink>; Department of Pharmacology and Experimental Therapeutics, LSU Health Sciences Center, New Orleans, Louisiana, USA.; Cardiovascular Center of Excellence, LSU Health Sciences Center, New Orleans, Louisiana, USA.<br /><searchLink fieldCode="AU" term="%22Yu+X%22">Yu X</searchLink>; Department of Cardiac Surgery, Smidt Heart Institute, Cedars-Sinai Medical Center, Los Angeles, California, USA.<br /><searchLink fieldCode="AU" term="%22Nevins+AR%22">Nevins AR</searchLink>; Department of Cardiac Surgery, Smidt Heart Institute, Cedars-Sinai Medical Center, Los Angeles, California, USA.<br /><searchLink fieldCode="AU" term="%22LaPenna+KB%22">LaPenna KB</searchLink>; Department of Pharmacology and Experimental Therapeutics, LSU Health Sciences Center, New Orleans, Louisiana, USA.<br /><searchLink fieldCode="AU" term="%22Sharp+TE+3rd%22">Sharp TE 3rd</searchLink>; Molecular Pharmacology and Physiology, University of South Florida, Tampa, Florida, USA.<br /><searchLink fieldCode="AU" term="%22Goodchild+TT%22">Goodchild TT</searchLink>; Department of Cardiac Surgery, Smidt Heart Institute, Cedars-Sinai Medical Center, Los Angeles, California, USA.<br /><searchLink fieldCode="AU" term="%22Allerton+TD%22">Allerton TD</searchLink>; Pennington Biomedical Research Center, Baton Rouge, Louisiana, USA.<br /><searchLink fieldCode="AU" term="%22Elgazzaz+M%22">Elgazzaz M</searchLink>; Department of Pharmacology and Experimental Therapeutics, LSU Health Sciences Center, New Orleans, Louisiana, USA.; Cardiovascular Center of Excellence, LSU Health Sciences Center, New Orleans, Louisiana, USA.<br /><searchLink fieldCode="AU" term="%22Lazartigues+E%22">Lazartigues E</searchLink>; Department of Pharmacology and Experimental Therapeutics, LSU Health Sciences Center, New Orleans, Louisiana, USA.; Cardiovascular Center of Excellence, LSU Health Sciences Center, New Orleans, Louisiana, USA.<br /><searchLink fieldCode="AU" term="%22Shah+SJ%22">Shah SJ</searchLink>; Feinberg School of Medicine, Northwestern University Medicine, Chicago, Illinois, USA.<br /><searchLink fieldCode="AU" term="%22Li+Z%22">Li Z</searchLink>; Department of Cardiac Surgery, Smidt Heart Institute, Cedars-Sinai Medical Center, Los Angeles, California, USA.<br /><searchLink fieldCode="AU" term="%22Lefer+DJ%22">Lefer DJ</searchLink>; Department of Cardiac Surgery, Smidt Heart Institute, Cedars-Sinai Medical Center, Los Angeles, California, USA.
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  Data: <searchLink fieldCode="JN" term="%227502536%22">British journal of pharmacology</searchLink> [Br J Pharmacol] 2024 Nov; Vol. 181 (21), pp. 4294-4310. <i>Date of Electronic Publication: </i>2024 Jul 09.
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