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A large-scale CRISPR screen reveals context-specific genetic regulation of retinal ganglion cell regeneration.

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Title: A large-scale CRISPR screen reveals context-specific genetic regulation of retinal ganglion cell regeneration.
Authors: Emmerich K; Wilmer Eye Institute and the Department of Ophthalmology, Johns Hopkins University School of Medicine, Baltimore, MD 21287, USA.; McKusick-Nathans Institute and the Department of Genetic Medicine, Johns Hopkins University School of Medicine, Baltimore, MD 21287, USA., Hageter J; Department of Biology, West Virginia University, Morgantown, WV 26505, USA., Hoang T; Wilmer Eye Institute and the Department of Ophthalmology, Johns Hopkins University School of Medicine, Baltimore, MD 21287, USA.; Department of Ophthalmology and Visual Sciences, University of Michigan School of Medicine, Ann Arbor, MI 48105, USA.; Department of Cell and Developmental Biology, University of Michigan School of Medicine, Ann Arbor, MI 48105, USA., Lyu P; Wilmer Eye Institute and the Department of Ophthalmology, Johns Hopkins University School of Medicine, Baltimore, MD 21287, USA., Sharrock AV; School of Biological Sciences, Victoria University of Wellington, Wellington 6012, New Zealand., Ceisel A; Wilmer Eye Institute and the Department of Ophthalmology, Johns Hopkins University School of Medicine, Baltimore, MD 21287, USA., Thierer J; Wilmer Eye Institute and the Department of Ophthalmology, Johns Hopkins University School of Medicine, Baltimore, MD 21287, USA., Chunawala Z; Wilmer Eye Institute and the Department of Ophthalmology, Johns Hopkins University School of Medicine, Baltimore, MD 21287, USA., Nimmagadda S; Wilmer Eye Institute and the Department of Ophthalmology, Johns Hopkins University School of Medicine, Baltimore, MD 21287, USA., Palazzo I; Institute for Cell Engineering, Johns Hopkins University School of Medicine, Baltimore, MD 21287, USA., Matthews F; Wilmer Eye Institute and the Department of Ophthalmology, Johns Hopkins University School of Medicine, Baltimore, MD 21287, USA., Zhang L; Wilmer Eye Institute and the Department of Ophthalmology, Johns Hopkins University School of Medicine, Baltimore, MD 21287, USA., White DT; Wilmer Eye Institute and the Department of Ophthalmology, Johns Hopkins University School of Medicine, Baltimore, MD 21287, USA., Rodriguez C; Wilmer Eye Institute and the Department of Ophthalmology, Johns Hopkins University School of Medicine, Baltimore, MD 21287, USA., Graziano G; Wilmer Eye Institute and the Department of Ophthalmology, Johns Hopkins University School of Medicine, Baltimore, MD 21287, USA., Marcos P; Wilmer Eye Institute and the Department of Ophthalmology, Johns Hopkins University School of Medicine, Baltimore, MD 21287, USA., May A; Wilmer Eye Institute and the Department of Ophthalmology, Johns Hopkins University School of Medicine, Baltimore, MD 21287, USA., Mulligan T; Wilmer Eye Institute and the Department of Ophthalmology, Johns Hopkins University School of Medicine, Baltimore, MD 21287, USA., Reibman B; Wilmer Eye Institute and the Department of Ophthalmology, Johns Hopkins University School of Medicine, Baltimore, MD 21287, USA., Saxena MT; Wilmer Eye Institute and the Department of Ophthalmology, Johns Hopkins University School of Medicine, Baltimore, MD 21287, USA., Ackerley DF; School of Biological Sciences, Victoria University of Wellington, Wellington 6012, New Zealand., Qian J; Wilmer Eye Institute and the Department of Ophthalmology, Johns Hopkins University School of Medicine, Baltimore, MD 21287, USA., Blackshaw S; Wilmer Eye Institute and the Department of Ophthalmology, Johns Hopkins University School of Medicine, Baltimore, MD 21287, USA.; McKusick-Nathans Institute and the Department of Genetic Medicine, Johns Hopkins University School of Medicine, Baltimore, MD 21287, USA.; Institute for Cell Engineering, Johns Hopkins University School of Medicine, Baltimore, MD 21287, USA.; Department of Neurology, Johns Hopkins University School of Medicine, Baltimore, MD 21287, USA.; Department of Neuroscience, Johns Hopkins University School of Medicine, Baltimore, MD 21287, USA., Horstick E; Department of Biology, West Virginia University, Morgantown, WV 26505, USA.; Department of Neuroscience, West Virginia University, Morgantown, WV 26506, USA., Mumm JS; Wilmer Eye Institute and the Department of Ophthalmology, Johns Hopkins University School of Medicine, Baltimore, MD 21287, USA.; McKusick-Nathans Institute and the Department of Genetic Medicine, Johns Hopkins University School of Medicine, Baltimore, MD 21287, USA.; Department of Neuroscience, Johns Hopkins University School of Medicine, Baltimore, MD 21287, USA.; Center for Nanomedicine, Johns Hopkins University School of Medicine, Baltimore, MD 21287, USA.
Source: Development (Cambridge, England) [Development] 2024 Aug 01; Vol. 151 (15). Date of Electronic Publication: 2024 Aug 12.
Publication Type: Journal Article
Journal Info: Publisher: Company Of Biologists Limited Country of Publication: England NLM ID: 8701744 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1477-9129 (Electronic) Linking ISSN: 09501991 NLM ISO Abbreviation: Development Subsets: MEDLINE
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  Data: <searchLink fieldCode="AU" term="%22Emmerich+K%22">Emmerich K</searchLink>; Wilmer Eye Institute and the Department of Ophthalmology, Johns Hopkins University School of Medicine, Baltimore, MD 21287, USA.; McKusick-Nathans Institute and the Department of Genetic Medicine, Johns Hopkins University School of Medicine, Baltimore, MD 21287, USA.<br /><searchLink fieldCode="AU" term="%22Hageter+J%22">Hageter J</searchLink>; Department of Biology, West Virginia University, Morgantown, WV 26505, USA.<br /><searchLink fieldCode="AU" term="%22Hoang+T%22">Hoang T</searchLink>; Wilmer Eye Institute and the Department of Ophthalmology, Johns Hopkins University School of Medicine, Baltimore, MD 21287, USA.; Department of Ophthalmology and Visual Sciences, University of Michigan School of Medicine, Ann Arbor, MI 48105, USA.; Department of Cell and Developmental Biology, University of Michigan School of Medicine, Ann Arbor, MI 48105, USA.<br /><searchLink fieldCode="AU" term="%22Lyu+P%22">Lyu P</searchLink>; Wilmer Eye Institute and the Department of Ophthalmology, Johns Hopkins University School of Medicine, Baltimore, MD 21287, USA.<br /><searchLink fieldCode="AU" term="%22Sharrock+AV%22">Sharrock AV</searchLink>; School of Biological Sciences, Victoria University of Wellington, Wellington 6012, New Zealand.<br /><searchLink fieldCode="AU" term="%22Ceisel+A%22">Ceisel A</searchLink>; Wilmer Eye Institute and the Department of Ophthalmology, Johns Hopkins University School of Medicine, Baltimore, MD 21287, USA.<br /><searchLink fieldCode="AU" term="%22Thierer+J%22">Thierer J</searchLink>; Wilmer Eye Institute and the Department of Ophthalmology, Johns Hopkins University School of Medicine, Baltimore, MD 21287, USA.<br /><searchLink fieldCode="AU" term="%22Chunawala+Z%22">Chunawala Z</searchLink>; Wilmer Eye Institute and the Department of Ophthalmology, Johns Hopkins University School of Medicine, Baltimore, MD 21287, USA.<br /><searchLink fieldCode="AU" term="%22Nimmagadda+S%22">Nimmagadda S</searchLink>; 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Wilmer Eye Institute and the Department of Ophthalmology, Johns Hopkins University School of Medicine, Baltimore, MD 21287, USA.<br /><searchLink fieldCode="AU" term="%22Saxena+MT%22">Saxena MT</searchLink>; Wilmer Eye Institute and the Department of Ophthalmology, Johns Hopkins University School of Medicine, Baltimore, MD 21287, USA.<br /><searchLink fieldCode="AU" term="%22Ackerley+DF%22">Ackerley DF</searchLink>; School of Biological Sciences, Victoria University of Wellington, Wellington 6012, New Zealand.<br /><searchLink fieldCode="AU" term="%22Qian+J%22">Qian J</searchLink>; Wilmer Eye Institute and the Department of Ophthalmology, Johns Hopkins University School of Medicine, Baltimore, MD 21287, USA.<br /><searchLink fieldCode="AU" term="%22Blackshaw+S%22">Blackshaw S</searchLink>; Wilmer Eye Institute and the Department of Ophthalmology, Johns Hopkins University School of Medicine, Baltimore, MD 21287, USA.; McKusick-Nathans Institute and the Department of Genetic Medicine, Johns Hopkins University School of Medicine, Baltimore, MD 21287, USA.; Institute for Cell Engineering, Johns Hopkins University School of Medicine, Baltimore, MD 21287, USA.; Department of Neurology, Johns Hopkins University School of Medicine, Baltimore, MD 21287, USA.; Department of Neuroscience, Johns Hopkins University School of Medicine, Baltimore, MD 21287, USA.<br /><searchLink fieldCode="AU" term="%22Horstick+E%22">Horstick E</searchLink>; Department of Biology, West Virginia University, Morgantown, WV 26505, USA.; Department of Neuroscience, West Virginia University, Morgantown, WV 26506, USA.<br /><searchLink fieldCode="AU" term="%22Mumm+JS%22">Mumm JS</searchLink>; Wilmer Eye Institute and the Department of Ophthalmology, Johns Hopkins University School of Medicine, Baltimore, MD 21287, USA.; McKusick-Nathans Institute and the Department of Genetic Medicine, Johns Hopkins University School of Medicine, Baltimore, MD 21287, USA.; Department of Neuroscience, Johns Hopkins University School of Medicine, Baltimore, MD 21287, USA.; Center for Nanomedicine, Johns Hopkins University School of Medicine, Baltimore, MD 21287, USA.
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