Phase 1 study of the pharmacokinetics and clinical proof-of-concept activity of a biofilm-disrupting human monoclonal antibody in patients with chronic prosthetic joint infection of the knee or hip.
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| Title: | Phase 1 study of the pharmacokinetics and clinical proof-of-concept activity of a biofilm-disrupting human monoclonal antibody in patients with chronic prosthetic joint infection of the knee or hip. |
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| Authors: | Conway J; Rubin Institute for Advanced Orthopedics, Sinai Hospital of Baltimore, LifeBridge Health, Baltimore, Maryland., Delanois RE; Rubin Institute for Advanced Orthopedics, Sinai Hospital of Baltimore, LifeBridge Health, Baltimore, Maryland., Mont MA; Rubin Institute for Advanced Orthopedics, Sinai Hospital of Baltimore, LifeBridge Health, Baltimore, Maryland., Stavrakis A; University of California Los Angeles, Los Angeles, California, USA., McPherson E; University of California Los Angeles, Los Angeles, California, USA., Stolarski E; Gulfcoast Research Institute, Sarasota, Florida, USA., Incavo S; Houston Methodist Hospital, Houston, Texas, USA., Oakes D; University of Southern California, Los Angeles, California, USA., Salvagno R; Meritus Medical Center, Hagerstown, Maryland, USA., Adams JS; University of California Los Angeles, Los Angeles, California, USA., Kisch-Hancock A; Trellis Bioscience, Inc., Redwood City, California, USA., Tenorio E; Trellis Bioscience, Inc., Redwood City, California, USA., Leighton A; Trellis Bioscience, Inc., Redwood City, California, USA., Ryser S; Trellis Bioscience, Inc., Redwood City, California, USA., Kauvar LM; Trellis Bioscience, Inc., Redwood City, California, USA., Bernthal NM; University of California Los Angeles, Los Angeles, California, USA. |
| Source: | Antimicrobial agents and chemotherapy [Antimicrob Agents Chemother] 2024 Aug 07; Vol. 68 (8), pp. e0065524. Date of Electronic Publication: 2024 Jul 16. |
| Publication Type: | Journal Article; Clinical Trial, Phase I; Randomized Controlled Trial; Research Support, Non-U.S. Gov't |
| Journal Info: | Publisher: American Society for Microbiology Country of Publication: United States NLM ID: 0315061 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1098-6596 (Electronic) Linking ISSN: 00664804 NLM ISO Abbreviation: Antimicrob Agents Chemother Subsets: MEDLINE |
| Database: | MEDLINE Ultimate |
| FullText | Text: Availability: 0 |
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| Header | DbId: mdl DbLabel: MEDLINE Ultimate An: 39012102 AccessLevel: 2 PubType: Academic Journal PubTypeId: academicJournal PreciseRelevancyScore: 0 |
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| Items | – Name: Title Label: Title Group: Ti Data: Phase 1 study of the pharmacokinetics and clinical proof-of-concept activity of a biofilm-disrupting human monoclonal antibody in patients with chronic prosthetic joint infection of the knee or hip. – Name: Author Label: Authors Group: Au Data: <searchLink fieldCode="AU" term="%22Conway+J%22">Conway J</searchLink>; Rubin Institute for Advanced Orthopedics, Sinai Hospital of Baltimore, LifeBridge Health, Baltimore, Maryland.<br /><searchLink fieldCode="AU" term="%22Delanois+RE%22">Delanois RE</searchLink>; Rubin Institute for Advanced Orthopedics, Sinai Hospital of Baltimore, LifeBridge Health, Baltimore, Maryland.<br /><searchLink fieldCode="AU" term="%22Mont+MA%22">Mont MA</searchLink>; Rubin Institute for Advanced Orthopedics, Sinai Hospital of Baltimore, LifeBridge Health, Baltimore, Maryland.<br /><searchLink fieldCode="AU" term="%22Stavrakis+A%22">Stavrakis A</searchLink>; University of California Los Angeles, Los Angeles, California, USA.<br /><searchLink fieldCode="AU" term="%22McPherson+E%22">McPherson E</searchLink>; University of California Los Angeles, Los Angeles, California, USA.<br /><searchLink fieldCode="AU" term="%22Stolarski+E%22">Stolarski E</searchLink>; Gulfcoast Research Institute, Sarasota, Florida, USA.<br /><searchLink fieldCode="AU" term="%22Incavo+S%22">Incavo S</searchLink>; Houston Methodist Hospital, Houston, Texas, USA.<br /><searchLink fieldCode="AU" term="%22Oakes+D%22">Oakes D</searchLink>; University of Southern California, Los Angeles, California, USA.<br /><searchLink fieldCode="AU" term="%22Salvagno+R%22">Salvagno R</searchLink>; Meritus Medical Center, Hagerstown, Maryland, USA.<br /><searchLink fieldCode="AU" term="%22Adams+JS%22">Adams JS</searchLink>; University of California Los Angeles, Los Angeles, California, USA.<br /><searchLink fieldCode="AU" term="%22Kisch-Hancock+A%22">Kisch-Hancock A</searchLink>; Trellis Bioscience, Inc., Redwood City, California, USA.<br /><searchLink fieldCode="AU" term="%22Tenorio+E%22">Tenorio E</searchLink>; Trellis Bioscience, Inc., Redwood City, California, USA.<br /><searchLink fieldCode="AU" term="%22Leighton+A%22">Leighton A</searchLink>; Trellis Bioscience, Inc., Redwood City, California, USA.<br /><searchLink fieldCode="AU" term="%22Ryser+S%22">Ryser S</searchLink>; Trellis Bioscience, Inc., Redwood City, California, USA.<br /><searchLink fieldCode="AU" term="%22Kauvar+LM%22">Kauvar LM</searchLink>; Trellis Bioscience, Inc., Redwood City, California, USA.<br /><searchLink fieldCode="AU" term="%22Bernthal+NM%22">Bernthal NM</searchLink>; University of California Los Angeles, Los Angeles, California, USA. – Name: TitleSource Label: Source Group: Src Data: <searchLink fieldCode="JN" term="%220315061%22">Antimicrobial agents and chemotherapy</searchLink> [Antimicrob Agents Chemother] 2024 Aug 07; Vol. 68 (8), pp. e0065524. <i>Date of Electronic Publication: </i>2024 Jul 16. – Name: TypePub Label: Publication Type Group: TypPub Data: Journal Article; Clinical Trial, Phase I; Randomized Controlled Trial; Research Support, Non-U.S. Gov't – Name: TitleSource Label: Journal Info Group: Src Data: <i>Publisher: </i><searchLink fieldCode="PB" term="%22American+Society+for+Microbiology%22">American Society for Microbiology </searchLink><i>Country of Publication: </i>United States <i>NLM ID: </i>0315061 <i>Publication Model: </i>Print-Electronic <i>Cited Medium: </i>Internet <i>ISSN: </i>1098-6596 (Electronic) <i>Linking ISSN: </i><searchLink fieldCode="IS" term="%2200664804%22">00664804 </searchLink><i>NLM ISO Abbreviation: </i>Antimicrob Agents Chemother <i>Subsets: </i>MEDLINE |
| PLink | https://search.ebscohost.com/login.aspx?direct=true&site=eds-live&db=mdl&AN=39012102 |
| RecordInfo | BibRecord: BibEntity: Identifiers: – Type: doi Value: 10.1128/aac.00655-24 Languages: – Code: eng Text: English PhysicalDescription: Pagination: StartPage: e0065524 Titles: – TitleFull: Phase 1 study of the pharmacokinetics and clinical proof-of-concept activity of a biofilm-disrupting human monoclonal antibody in patients with chronic prosthetic joint infection of the knee or hip. Type: main BibRelationships: HasContributorRelationships: – PersonEntity: Name: NameFull: Conway J – PersonEntity: Name: NameFull: Delanois RE – PersonEntity: Name: NameFull: Mont MA – PersonEntity: Name: NameFull: Stavrakis A – PersonEntity: Name: NameFull: McPherson E – PersonEntity: Name: NameFull: Stolarski E – PersonEntity: Name: NameFull: Incavo S – PersonEntity: Name: NameFull: Oakes D – PersonEntity: Name: NameFull: Salvagno R – PersonEntity: Name: NameFull: Adams JS – PersonEntity: Name: NameFull: Kisch-Hancock A – PersonEntity: Name: NameFull: Tenorio E – PersonEntity: Name: NameFull: Leighton A – PersonEntity: Name: NameFull: Ryser S – PersonEntity: Name: NameFull: Kauvar LM – PersonEntity: Name: NameFull: Bernthal NM IsPartOfRelationships: – BibEntity: Dates: – D: 07 M: 08 Text: 2024 Aug 07 Type: published Y: 2024 Identifiers: – Type: issn-electronic Value: 1098-6596 Numbering: – Type: volume Value: 68 – Type: issue Value: 8 Titles: – TitleFull: Antimicrobial agents and chemotherapy Type: main |
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