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Mutational profiling of SARS-CoV-2 papain-like protease reveals requirements for function, structure, and drug escape.

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Title: Mutational profiling of SARS-CoV-2 papain-like protease reveals requirements for function, structure, and drug escape.
Authors: Wu X; The Walter and Eliza Hall Institute of Medical Research, Parkville, VIC, Australia.; Department of Medical Biology, University of Melbourne, Parkville, VIC, Australia., Go M; The Walter and Eliza Hall Institute of Medical Research, Parkville, VIC, Australia., Nguyen JV; The Walter and Eliza Hall Institute of Medical Research, Parkville, VIC, Australia., Kuchel NW; The Walter and Eliza Hall Institute of Medical Research, Parkville, VIC, Australia.; Department of Medical Biology, University of Melbourne, Parkville, VIC, Australia., Lu BGC; The Walter and Eliza Hall Institute of Medical Research, Parkville, VIC, Australia.; Department of Medical Biology, University of Melbourne, Parkville, VIC, Australia., Zeglinski K; The Walter and Eliza Hall Institute of Medical Research, Parkville, VIC, Australia.; Department of Medical Biology, University of Melbourne, Parkville, VIC, Australia., Lowes KN; The Walter and Eliza Hall Institute of Medical Research, Parkville, VIC, Australia.; Department of Medical Biology, University of Melbourne, Parkville, VIC, Australia., Calleja DJ; The Walter and Eliza Hall Institute of Medical Research, Parkville, VIC, Australia.; Department of Medical Biology, University of Melbourne, Parkville, VIC, Australia., Mitchell JP; The Walter and Eliza Hall Institute of Medical Research, Parkville, VIC, Australia.; Department of Medical Biology, University of Melbourne, Parkville, VIC, Australia., Lessene G; The Walter and Eliza Hall Institute of Medical Research, Parkville, VIC, Australia.; Department of Medical Biology, University of Melbourne, Parkville, VIC, Australia.; Department of Biochemistry and Pharmacology, University of Melbourne, Parkville, VIC, Australia., Komander D; The Walter and Eliza Hall Institute of Medical Research, Parkville, VIC, Australia.; Department of Medical Biology, University of Melbourne, Parkville, VIC, Australia., Call ME; The Walter and Eliza Hall Institute of Medical Research, Parkville, VIC, Australia.; Department of Medical Biology, University of Melbourne, Parkville, VIC, Australia., Call MJ; The Walter and Eliza Hall Institute of Medical Research, Parkville, VIC, Australia. mjcall@wehi.edu.au.; Department of Medical Biology, University of Melbourne, Parkville, VIC, Australia. mjcall@wehi.edu.au.
Source: Nature communications [Nat Commun] 2024 Jul 23; Vol. 15 (1), pp. 6219. Date of Electronic Publication: 2024 Jul 23.
Publication Type: Journal Article; Research Support, Non-U.S. Gov't
Journal Info: Publisher: Nature Pub. Group Country of Publication: England NLM ID: 101528555 Publication Model: Electronic Cited Medium: Internet ISSN: 2041-1723 (Electronic) Linking ISSN: 20411723 NLM ISO Abbreviation: Nat Commun Subsets: MEDLINE
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