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Bioactivity-driven fungal metabologenomics identifies antiproliferative stemphone analogs and their biosynthetic gene cluster.

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Title: Bioactivity-driven fungal metabologenomics identifies antiproliferative stemphone analogs and their biosynthetic gene cluster.
Authors: Ayon NJ; Department of Chemistry, Northwestern University, Evanston, IL, USA.; Proteomics Center of Excellence, Northwestern University, Evanston, IL, USA., Earp CE; Department of Chemistry and Biochemistry, University of North Carolina at Greensboro, Greensboro, NC, USA., Gupta R; Department of Chemistry, Northwestern University, Evanston, IL, USA., Butun FA; Department of Chemistry, Northwestern University, Evanston, IL, USA.; Proteomics Center of Excellence, Northwestern University, Evanston, IL, USA., Clements AE; Department of Chemistry and Biochemistry, James Madison University, Harrisonburg, VA, USA., Lee AG; Department of Chemistry and Biochemistry, James Madison University, Harrisonburg, VA, USA., Dainko D; Department of Chemistry, Northwestern University, Evanston, IL, USA., Robey MT; Department of Molecular Biosciences, Northwestern University, Evanston, IL, USA., Khin M; College of Pharmacy-Pharmaceutical Science, University of Illinois Chicago, Chicago, IL, USA., Mardiana L; Chemistry, School of Natural and Environmental Sciences, Newcastle University, Newcastle Upon Tyne, NE1 7RU, UK.; Department of Chemistry, Universitas Indonesia, Depok, Jawa Barat, Indonesia.; Indicatrix Crystallography, Newcastle University, Newcastle Upon Tyne, NE1 7RU, UK., Longcake A; Chemistry, School of Natural and Environmental Sciences, Newcastle University, Newcastle Upon Tyne, NE1 7RU, UK., Rangel-Grimaldo M; Department of Chemistry and Biochemistry, University of North Carolina at Greensboro, Greensboro, NC, USA., Hall MJ; Chemistry, School of Natural and Environmental Sciences, Newcastle University, Newcastle Upon Tyne, NE1 7RU, UK., Probert MR; Chemistry, School of Natural and Environmental Sciences, Newcastle University, Newcastle Upon Tyne, NE1 7RU, UK., Burdette JE; College of Pharmacy-Pharmaceutical Science, University of Illinois Chicago, Chicago, IL, USA., Keller NP; Department of Medical Microbiology and Immunology, University of Wisconsin-Madison, Madison, WI, USA.; Department of Bacteriology, University of Wisconsin-Madison, Madison, WI, USA., Raja HA; Department of Chemistry and Biochemistry, University of North Carolina at Greensboro, Greensboro, NC, USA., Oberlies NH; Department of Chemistry and Biochemistry, University of North Carolina at Greensboro, Greensboro, NC, USA., Kelleher NL; Department of Chemistry, Northwestern University, Evanston, IL, USA.; Proteomics Center of Excellence, Northwestern University, Evanston, IL, USA.; Department of Molecular Biosciences, Northwestern University, Evanston, IL, USA., Caesar LK; Department of Chemistry and Biochemistry, James Madison University, Harrisonburg, VA, USA. caesarlk@jmu.edu.
Source: Metabolomics : Official journal of the Metabolomic Society [Metabolomics] 2024 Aug 02; Vol. 20 (5), pp. 90. Date of Electronic Publication: 2024 Aug 02.
Publication Type: Journal Article
Journal Info: Publisher: Springer Country of Publication: United States NLM ID: 101274889 Publication Model: Electronic Cited Medium: Internet ISSN: 1573-3890 (Electronic) Linking ISSN: 15733882 NLM ISO Abbreviation: Metabolomics Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: Bioactivity-driven fungal metabologenomics identifies antiproliferative stemphone analogs and their biosynthetic gene cluster.
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  Data: <searchLink fieldCode="AU" term="%22Ayon+NJ%22">Ayon NJ</searchLink>; Department of Chemistry, Northwestern University, Evanston, IL, USA.; Proteomics Center of Excellence, Northwestern University, Evanston, IL, USA.<br /><searchLink fieldCode="AU" term="%22Earp+CE%22">Earp CE</searchLink>; Department of Chemistry and Biochemistry, University of North Carolina at Greensboro, Greensboro, NC, USA.<br /><searchLink fieldCode="AU" term="%22Gupta+R%22">Gupta R</searchLink>; Department of Chemistry, Northwestern University, Evanston, IL, USA.<br /><searchLink fieldCode="AU" term="%22Butun+FA%22">Butun FA</searchLink>; Department of Chemistry, Northwestern University, Evanston, IL, USA.; Proteomics Center of Excellence, Northwestern University, Evanston, IL, USA.<br /><searchLink fieldCode="AU" term="%22Clements+AE%22">Clements AE</searchLink>; Department of Chemistry and Biochemistry, James Madison University, Harrisonburg, VA, USA.<br /><searchLink fieldCode="AU" term="%22Lee+AG%22">Lee AG</searchLink>; Department of Chemistry and Biochemistry, James Madison University, Harrisonburg, VA, USA.<br /><searchLink fieldCode="AU" term="%22Dainko+D%22">Dainko D</searchLink>; Department of Chemistry, Northwestern University, Evanston, IL, USA.<br /><searchLink fieldCode="AU" term="%22Robey+MT%22">Robey MT</searchLink>; Department of Molecular Biosciences, Northwestern University, Evanston, IL, USA.<br /><searchLink fieldCode="AU" term="%22Khin+M%22">Khin M</searchLink>; College of Pharmacy-Pharmaceutical Science, University of Illinois Chicago, Chicago, IL, USA.<br /><searchLink fieldCode="AU" term="%22Mardiana+L%22">Mardiana L</searchLink>; Chemistry, School of Natural and Environmental Sciences, Newcastle University, Newcastle Upon Tyne, NE1 7RU, UK.; Department of Chemistry, Universitas Indonesia, Depok, Jawa Barat, Indonesia.; Indicatrix Crystallography, Newcastle University, Newcastle Upon Tyne, NE1 7RU, UK.<br /><searchLink fieldCode="AU" term="%22Longcake+A%22">Longcake A</searchLink>; Chemistry, School of Natural and Environmental Sciences, Newcastle University, Newcastle Upon Tyne, NE1 7RU, UK.<br /><searchLink fieldCode="AU" term="%22Rangel-Grimaldo+M%22">Rangel-Grimaldo M</searchLink>; Department of Chemistry and Biochemistry, University of North Carolina at Greensboro, Greensboro, NC, USA.<br /><searchLink fieldCode="AU" term="%22Hall+MJ%22">Hall MJ</searchLink>; Chemistry, School of Natural and Environmental Sciences, Newcastle University, Newcastle Upon Tyne, NE1 7RU, UK.<br /><searchLink fieldCode="AU" term="%22Probert+MR%22">Probert MR</searchLink>; Chemistry, School of Natural and Environmental Sciences, Newcastle University, Newcastle Upon Tyne, NE1 7RU, UK.<br /><searchLink fieldCode="AU" term="%22Burdette+JE%22">Burdette JE</searchLink>; College of Pharmacy-Pharmaceutical Science, University of Illinois Chicago, Chicago, IL, USA.<br /><searchLink fieldCode="AU" term="%22Keller+NP%22">Keller NP</searchLink>; Department of Medical Microbiology and Immunology, University of Wisconsin-Madison, Madison, WI, USA.; Department of Bacteriology, University of Wisconsin-Madison, Madison, WI, USA.<br /><searchLink fieldCode="AU" term="%22Raja+HA%22">Raja HA</searchLink>; Department of Chemistry and Biochemistry, University of North Carolina at Greensboro, Greensboro, NC, USA.<br /><searchLink fieldCode="AU" term="%22Oberlies+NH%22">Oberlies NH</searchLink>; Department of Chemistry and Biochemistry, University of North Carolina at Greensboro, Greensboro, NC, USA.<br /><searchLink fieldCode="AU" term="%22Kelleher+NL%22">Kelleher NL</searchLink>; Department of Chemistry, Northwestern University, Evanston, IL, USA.; Proteomics Center of Excellence, Northwestern University, Evanston, IL, USA.; Department of Molecular Biosciences, Northwestern University, Evanston, IL, USA.<br /><searchLink fieldCode="AU" term="%22Caesar+LK%22">Caesar LK</searchLink>; Department of Chemistry and Biochemistry, James Madison University, Harrisonburg, VA, USA. caesarlk@jmu.edu.
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  Data: <searchLink fieldCode="JN" term="%22101274889%22">Metabolomics : Official journal of the Metabolomic Society</searchLink> [Metabolomics] 2024 Aug 02; Vol. 20 (5), pp. 90. <i>Date of Electronic Publication: </i>2024 Aug 02.
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  Data: <i>Publisher: </i><searchLink fieldCode="PB" term="%22Springer%22">Springer </searchLink><i>Country of Publication: </i>United States <i>NLM ID: </i>101274889 <i>Publication Model: </i>Electronic <i>Cited Medium: </i>Internet <i>ISSN: </i>1573-3890 (Electronic) <i>Linking ISSN: </i><searchLink fieldCode="IS" term="%2215733882%22">15733882 </searchLink><i>NLM ISO Abbreviation: </i>Metabolomics <i>Subsets: </i>MEDLINE
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