Molecularly guided therapy versus chemotherapy after disease control in unfavourable cancer of unknown primary (CUPISCO): an open-label, randomised, phase 2 study.

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Title: Molecularly guided therapy versus chemotherapy after disease control in unfavourable cancer of unknown primary (CUPISCO): an open-label, randomised, phase 2 study.
Authors: Krämer A; Clinical Cooperation Unit Molecular Hematology-Oncology, German Cancer Research Center (DKFZ), Heidelberg, Germany; Department of Internal Medicine V, University of Heidelberg, Heidelberg, Germany. Electronic address: a.kraemer@dkfz-heidelberg.de., Bochtler T; Clinical Cooperation Unit Molecular Hematology-Oncology, German Cancer Research Center (DKFZ), Heidelberg, Germany; Department of Internal Medicine V, University of Heidelberg, Heidelberg, Germany; Department of Medical Oncology, National Center for Tumor Diseases, Heidelberg University Hospital, Heidelberg, Germany., Pauli C; Department of Pathology and Molecular Pathology, University Hospital Zurich, Zurich, Switzerland; Department of Pathology and Molecular Pathology, University Hospital of Zurich, Zurich, Switzerland; Medical Faculty, University of Zurich, Zurich, Switzerland., Shiu KK; UCLH Gastrointestinal Oncology Service, Cancer of Unknown Primary Service, University College London, Cancer Institute, London, UK., Cook N; The Christie NHS Foundation Trust and Division of Cancer Sciences, Faculty of Biology, Medicine and Health, University of Manchester, Manchester, UK., de Menezes JJ; Clinical Oncology, Centro Integrado de Pesquisa em Oncologia, Porto Alegre, Brazil., Pazo-Cid RA; Medical Oncology Department, Miguel Servet University Hospital, Zaragoza, Spain., Losa F; Medical Oncology Department, Hospital de Sant Joan Despí Moisès Broggi, ICO Hospitalet, Barcelona, Spain., Robbrecht DG; Department of Medical Oncology, Erasmus MC Cancer Institute, Erasmus University Medical Center, Rotterdam, Netherlands., Tomášek J; Masaryk Memorial Cancer Institute, Brno, Czech Republic., Arslan C; Izmir University of Economics Medical Point Hospital, Izmir, Türkiye., Özgüroğlu M; Istanbul University Cerrahpasa, Cerrahpasa Faculty of Medicine, Department of Internal Medicine, Division of Oncology, Istanbul, Türkiye., Stahl M; Evang Kliniken Essen-Mitte, Essen, Germany., Bigot F; Department of Medical Oncology, Institut de Cancérologie de l'Ouest, Angers, France., Kim SY; Department of Oncology, Asan Medical Center, University of Ulsan College of Medicine, Seoul, South Korea., Naito Y; Department of General Internal Medicine, National Cancer Center Hospital East, Kashiwa, Japan., Italiano A; Institut Bergonie, Early Phase Trials and Sarcoma Units, Bordeaux, France., Chalabi N; Global Product Development Medical Affairs, F Hoffmann-La Roche, Basel, Switzerland., Durán-Pacheco G; Global Product Development Medical Affairs, F Hoffmann-La Roche, Basel, Switzerland., Michaud C; Global Product Development Medical Affairs, F Hoffmann-La Roche, Basel, Switzerland., Scarato J; Global Product Development Medical Affairs, F Hoffmann-La Roche, Basel, Switzerland., Thomas M; Global Product Development Medical Affairs, F Hoffmann-La Roche, Basel, Switzerland., Ross JS; Pathology Group, Foundation Medicine, Cambridge, MA, USA; Upstate Medical University Departments of Pathology, Urology and Medicine (Oncology), Syracuse, NY, USA., Moch H; Department of Pathology and Molecular Pathology, University Hospital Zurich, Zurich, Switzerland; Department of Pathology and Molecular Pathology, University Hospital of Zurich, Zurich, Switzerland; Medical Faculty, University of Zurich, Zurich, Switzerland., Mileshkin L; Department of Medical Oncology, Peter MacCallum Cancer Centre, Melbourne, VIC, Australia.
Source: Lancet (London, England) [Lancet] 2024 Aug 10; Vol. 404 (10452), pp. 527-539. Date of Electronic Publication: 2024 Jul 31.
Publication Type: Journal Article; Clinical Trial, Phase II; Randomized Controlled Trial; Multicenter Study; Comparative Study; Research Support, Non-U.S. Gov't
Journal Info: Publisher: Elsevier Country of Publication: England NLM ID: 2985213R Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1474-547X (Electronic) Linking ISSN: 01406736 NLM ISO Abbreviation: Lancet Subsets: MEDLINE
Database: MEDLINE Ultimate
Description
ISSN:1474-547X
DOI:10.1016/S0140-6736(24)00814-6