In situ deposition of nanobodies by an engineered commensal microbe promotes survival in a mouse model of enterohemorrhagic E. coli.

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Title: In situ deposition of nanobodies by an engineered commensal microbe promotes survival in a mouse model of enterohemorrhagic E. coli.
Authors: Srivastava R; Center for Bacterial Pathogenesis, Division of Infectious Diseases, Department of Medicine, Massachusetts General Hospital, MA, 02115, USA.; Department of Microbiology, Blavatnik Institute, Harvard Medical School, Boston, MA, 02115, USA., González-Prieto C; Center for Bacterial Pathogenesis, Division of Infectious Diseases, Department of Medicine, Massachusetts General Hospital, MA, 02115, USA.; Department of Microbiology, Blavatnik Institute, Harvard Medical School, Boston, MA, 02115, USA., Lynch JP; Center for Bacterial Pathogenesis, Division of Infectious Diseases, Department of Medicine, Massachusetts General Hospital, MA, 02115, USA.; Department of Microbiology, Blavatnik Institute, Harvard Medical School, Boston, MA, 02115, USA., Muscolo M; Center for Bacterial Pathogenesis, Division of Infectious Diseases, Department of Medicine, Massachusetts General Hospital, MA, 02115, USA., Lin CY; Center for Bacterial Pathogenesis, Division of Infectious Diseases, Department of Medicine, Massachusetts General Hospital, MA, 02115, USA., Brown MA; Center for Bacterial Pathogenesis, Division of Infectious Diseases, Department of Medicine, Massachusetts General Hospital, MA, 02115, USA.; Department of Microbiology, Blavatnik Institute, Harvard Medical School, Boston, MA, 02115, USA., Lemos L; Center for Bacterial Pathogenesis, Division of Infectious Diseases, Department of Medicine, Massachusetts General Hospital, MA, 02115, USA.; Department of Microbiology, Blavatnik Institute, Harvard Medical School, Boston, MA, 02115, USA., Shrestha A; Department of Molecular Biology and Microbiology, Tufts University School of Medicine, Boston, MA, 02111, USA., Osburne MS; Department of Molecular Biology and Microbiology, Tufts University School of Medicine, Boston, MA, 02111, USA., Leong JM; Department of Molecular Biology and Microbiology, Tufts University School of Medicine, Boston, MA, 02111, USA.; Tufts Stuart B Levy Center for Integrated Management of Antimicrobial Resistance, Tufts University, Boston, MA, 02111, USA., Lesser CF; Center for Bacterial Pathogenesis, Division of Infectious Diseases, Department of Medicine, Massachusetts General Hospital, MA, 02115, USA.; Department of Microbiology, Blavatnik Institute, Harvard Medical School, Boston, MA, 02115, USA.; Broad Institute of MIT and Harvard, Cambridge, MA, 02142, USA.; Ragon Institute of Harvard and MIT, Cambridge, MA, 02139, USA.
Source: BioRxiv : the preprint server for biology [bioRxiv] 2024 Jul 30. Date of Electronic Publication: 2024 Jul 30.
Publication Type: Journal Article; Preprint
Journal Info: Country of Publication: United States NLM ID: 101680187 Publication Model: Electronic Cited Medium: Internet ISSN: 2692-8205 (Electronic) Linking ISSN: 26928205 NLM ISO Abbreviation: bioRxiv Subsets: PubMed not MEDLINE
Database: MEDLINE Ultimate
Description
ISSN:2692-8205
DOI:10.1101/2024.07.30.605899