Polygenic and developmental profiles of autism differ by age at diagnosis.

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Bibliographic Details
Title: Polygenic and developmental profiles of autism differ by age at diagnosis.
Authors: Zhang X; Department of Psychiatry, University of Cambridge.; Autism Research Centre, Department of Psychiatry, University of Cambridge, Cambridge, UK., Grove J; The Lundbeck Foundation Initiative for Integrative Psychiatric Research, iPSYCH, Aarhus, Denmark.; Center for Genomics and Personalized Medicine (CGPM), Aarhus University, Aarhus, Denmark.; Department of Biomedicine (Human Genetics) and iSEQ Center, Aarhus University, Aarhus, Denmark.; Bioinformatics Research Centre, Aarhus University, Aarhus, Denmark., Gu Y; Department of Psychiatry, University of Cambridge.; Autism Research Centre, Department of Psychiatry, University of Cambridge, Cambridge, UK., Buus CK; Department of Biomedicine (Human Genetics) and iSEQ Center, Aarhus University, Aarhus, Denmark., Nielsen LK; Department of Biomedicine (Human Genetics) and iSEQ Center, Aarhus University, Aarhus, Denmark., Neufeld SAS; Department of Psychiatry, University of Cambridge., Koko M; Human Genetics Programme, Wellcome Sanger Institute, Wellcome Genome Campus, Hinxton, CB10 1SA, UK., Malawsky DS; Human Genetics Programme, Wellcome Sanger Institute, Wellcome Genome Campus, Hinxton, CB10 1SA, UK., Wade EM; Human Genetics Programme, Wellcome Sanger Institute, Wellcome Genome Campus, Hinxton, CB10 1SA, UK., Verhoef E; Language and Genetics Department, Max Planck Institute for Psycholinguistics, Nijmegen, The Netherlands., Gui A; Department of Systems Medicine, University of Rome Tor Vergata, via Montpellier 1, 00133 Rome, Italy.; Centre for Brain and Cognitive Development, Department of Psychological Sciences, Birkbeck University of London, London, WC1E 7HX, United Kingdom., Hegemann L; Research Department, Lovisenberg Diaconal Hospital, Oslo, Norway.; PsychGen Centre for Genetic Epidemiology and Mental Health, Norwegian Institute of Public Health, Oslo, Norway., Geschwind DH; Program in Neurobehavioral Genetics and Center for Autism Research and Treatment, Semel Institute, David Geffen School of Medicine, University of California, Los Angeles, Los Angeles, CA 90095, USA.; Program in Neurogenetics, Department of Neurology, David Geffen School of Medicine, University of California, Los Angeles, Los Angeles, CA 90095, USA.; Department of Psychiatry, Semel Institute, David Geffen School of Medicine, University of California, Los Angeles, Los Angeles, CA 90095, USA.; Department of Human Genetics, David Geffen School of Medicine, University of California, Los Angeles, Los Angeles, CA 90095, USA., Wray NR; Institute for Molecular Bioscience, University of Queensland, Brisbane, QLD 4072, Australia.; Department of Psychiatry, University of Oxford, Oxford, OX3 7JX, United Kingdom., Havdahl A; Research Department, Lovisenberg Diaconal Hospital, Oslo, Norway.; PsychGen Centre for Genetic Epidemiology and Mental Health, Norwegian Institute of Public Health, Oslo, Norway.; Promenta Research Centre, Department of Psychology, University of Oslo, Oslo, Norway., Ronald A; Centre for Brain and Cognitive Development, Department of Psychological Sciences, Birkbeck University of London, London, WC1E 7HX, United Kingdom.; School of Psychology, University of Surrey, Guildford, Surrey, GU2 7XH, United Kingdom., St Pourcain B; Language and Genetics Department, Max Planck Institute for Psycholinguistics, Nijmegen, The Netherlands.; MRC Integrative Epidemiology Unit, University of Bristol, United Kingdom.; Donders Institute for Brain, Cognition and Behaviour, Radboud University, The Netherlands., Robinson EB; Center for Genomic Medicine, Massachusetts General Hospital, Boston, MA, USA.; The Broad Institute of MIT and Harvard, Cambridge, MA, USA., Bourgeron T; Human Genetics and Cognitive Functions, Institut Pasteur, UMR3571 CNRS, IUF, Université Paris Cité, Paris, France., Baron-Cohen S; Department of Psychiatry, University of Cambridge.; Autism Research Centre, Department of Psychiatry, University of Cambridge, Cambridge, UK.; Department of Psychology, University of Cambridge, Cambridge, UK., Børglum AD; The Lundbeck Foundation Initiative for Integrative Psychiatric Research, iPSYCH, Aarhus, Denmark.; Center for Genomics and Personalized Medicine (CGPM), Aarhus University, Aarhus, Denmark.; Department of Biomedicine (Human Genetics) and iSEQ Center, Aarhus University, Aarhus, Denmark., Martin HC; Human Genetics Programme, Wellcome Sanger Institute, Wellcome Genome Campus, Hinxton, CB10 1SA, UK., Warrier V; Department of Psychiatry, University of Cambridge.; Autism Research Centre, Department of Psychiatry, University of Cambridge, Cambridge, UK.; Department of Psychology, University of Cambridge, Cambridge, UK.
Corporate Authors: APEX consortium, iPSYCH Autism Consortium, PGC-PTSD Consortium
Source: MedRxiv : the preprint server for health sciences [medRxiv] 2025 Jul 17. Date of Electronic Publication: 2025 Jul 17.
Publication Type: Journal Article; Preprint
Journal Info: Country of Publication: United States NLM ID: 101767986 Publication Model: Electronic Cited Medium: Internet NLM ISO Abbreviation: medRxiv Subsets: PubMed not MEDLINE
Database: MEDLINE Ultimate
Description
DOI:10.1101/2024.07.31.24311279