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Polygenic and developmental profiles of autism differ by age at diagnosis.

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Title: Polygenic and developmental profiles of autism differ by age at diagnosis.
Authors: Zhang X; Department of Psychiatry, University of Cambridge.; Autism Research Centre, Department of Psychiatry, University of Cambridge, Cambridge, UK., Grove J; The Lundbeck Foundation Initiative for Integrative Psychiatric Research, iPSYCH, Aarhus, Denmark.; Center for Genomics and Personalized Medicine (CGPM), Aarhus University, Aarhus, Denmark.; Department of Biomedicine (Human Genetics) and iSEQ Center, Aarhus University, Aarhus, Denmark.; Bioinformatics Research Centre, Aarhus University, Aarhus, Denmark., Gu Y; Department of Psychiatry, University of Cambridge.; Autism Research Centre, Department of Psychiatry, University of Cambridge, Cambridge, UK., Buus CK; Department of Biomedicine (Human Genetics) and iSEQ Center, Aarhus University, Aarhus, Denmark., Nielsen LK; Department of Biomedicine (Human Genetics) and iSEQ Center, Aarhus University, Aarhus, Denmark., Neufeld SAS; Department of Psychiatry, University of Cambridge., Koko M; Human Genetics Programme, Wellcome Sanger Institute, Wellcome Genome Campus, Hinxton, CB10 1SA, UK., Malawsky DS; Human Genetics Programme, Wellcome Sanger Institute, Wellcome Genome Campus, Hinxton, CB10 1SA, UK., Wade EM; Human Genetics Programme, Wellcome Sanger Institute, Wellcome Genome Campus, Hinxton, CB10 1SA, UK., Verhoef E; Language and Genetics Department, Max Planck Institute for Psycholinguistics, Nijmegen, The Netherlands., Gui A; Department of Systems Medicine, University of Rome Tor Vergata, via Montpellier 1, 00133 Rome, Italy.; Centre for Brain and Cognitive Development, Department of Psychological Sciences, Birkbeck University of London, London, WC1E 7HX, United Kingdom., Hegemann L; Research Department, Lovisenberg Diaconal Hospital, Oslo, Norway.; PsychGen Centre for Genetic Epidemiology and Mental Health, Norwegian Institute of Public Health, Oslo, Norway., Geschwind DH; Program in Neurobehavioral Genetics and Center for Autism Research and Treatment, Semel Institute, David Geffen School of Medicine, University of California, Los Angeles, Los Angeles, CA 90095, USA.; Program in Neurogenetics, Department of Neurology, David Geffen School of Medicine, University of California, Los Angeles, Los Angeles, CA 90095, USA.; Department of Psychiatry, Semel Institute, David Geffen School of Medicine, University of California, Los Angeles, Los Angeles, CA 90095, USA.; Department of Human Genetics, David Geffen School of Medicine, University of California, Los Angeles, Los Angeles, CA 90095, USA., Wray NR; Institute for Molecular Bioscience, University of Queensland, Brisbane, QLD 4072, Australia.; Department of Psychiatry, University of Oxford, Oxford, OX3 7JX, United Kingdom., Havdahl A; Research Department, Lovisenberg Diaconal Hospital, Oslo, Norway.; PsychGen Centre for Genetic Epidemiology and Mental Health, Norwegian Institute of Public Health, Oslo, Norway.; Promenta Research Centre, Department of Psychology, University of Oslo, Oslo, Norway., Ronald A; Centre for Brain and Cognitive Development, Department of Psychological Sciences, Birkbeck University of London, London, WC1E 7HX, United Kingdom.; School of Psychology, University of Surrey, Guildford, Surrey, GU2 7XH, United Kingdom., St Pourcain B; Language and Genetics Department, Max Planck Institute for Psycholinguistics, Nijmegen, The Netherlands.; MRC Integrative Epidemiology Unit, University of Bristol, United Kingdom.; Donders Institute for Brain, Cognition and Behaviour, Radboud University, The Netherlands., Robinson EB; Center for Genomic Medicine, Massachusetts General Hospital, Boston, MA, USA.; The Broad Institute of MIT and Harvard, Cambridge, MA, USA., Bourgeron T; Human Genetics and Cognitive Functions, Institut Pasteur, UMR3571 CNRS, IUF, Université Paris Cité, Paris, France., Baron-Cohen S; Department of Psychiatry, University of Cambridge.; Autism Research Centre, Department of Psychiatry, University of Cambridge, Cambridge, UK.; Department of Psychology, University of Cambridge, Cambridge, UK., Børglum AD; The Lundbeck Foundation Initiative for Integrative Psychiatric Research, iPSYCH, Aarhus, Denmark.; Center for Genomics and Personalized Medicine (CGPM), Aarhus University, Aarhus, Denmark.; Department of Biomedicine (Human Genetics) and iSEQ Center, Aarhus University, Aarhus, Denmark., Martin HC; Human Genetics Programme, Wellcome Sanger Institute, Wellcome Genome Campus, Hinxton, CB10 1SA, UK., Warrier V; Department of Psychiatry, University of Cambridge.; Autism Research Centre, Department of Psychiatry, University of Cambridge, Cambridge, UK.; Department of Psychology, University of Cambridge, Cambridge, UK.
Corporate Authors: APEX consortium, iPSYCH Autism Consortium, PGC-PTSD Consortium
Source: MedRxiv : the preprint server for health sciences [medRxiv] 2025 Jul 17. Date of Electronic Publication: 2025 Jul 17.
Publication Type: Journal Article; Preprint
Journal Info: Country of Publication: United States NLM ID: 101767986 Publication Model: Electronic Cited Medium: Internet NLM ISO Abbreviation: medRxiv Subsets: PubMed not MEDLINE
Database: MEDLINE Ultimate
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  Data: Polygenic and developmental profiles of autism differ by age at diagnosis.
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  Data: <searchLink fieldCode="AU" term="%22Zhang+X%22">Zhang X</searchLink>; Department of Psychiatry, University of Cambridge.; Autism Research Centre, Department of Psychiatry, University of Cambridge, Cambridge, UK.<br /><searchLink fieldCode="AU" term="%22Grove+J%22">Grove J</searchLink>; The Lundbeck Foundation Initiative for Integrative Psychiatric Research, iPSYCH, Aarhus, Denmark.; Center for Genomics and Personalized Medicine (CGPM), Aarhus University, Aarhus, Denmark.; Department of Biomedicine (Human Genetics) and iSEQ Center, Aarhus University, Aarhus, Denmark.; Bioinformatics Research Centre, Aarhus University, Aarhus, Denmark.<br /><searchLink fieldCode="AU" term="%22Gu+Y%22">Gu Y</searchLink>; Department of Psychiatry, University of Cambridge.; Autism Research Centre, Department of Psychiatry, University of Cambridge, Cambridge, UK.<br /><searchLink fieldCode="AU" term="%22Buus+CK%22">Buus CK</searchLink>; Department of Biomedicine (Human Genetics) and iSEQ Center, Aarhus University, Aarhus, Denmark.<br /><searchLink fieldCode="AU" term="%22Nielsen+LK%22">Nielsen LK</searchLink>; Department of Biomedicine (Human Genetics) and iSEQ Center, Aarhus University, Aarhus, Denmark.<br /><searchLink fieldCode="AU" term="%22Neufeld+SAS%22">Neufeld SAS</searchLink>; Department of Psychiatry, University of Cambridge.<br /><searchLink fieldCode="AU" term="%22Koko+M%22">Koko M</searchLink>; Human Genetics Programme, Wellcome Sanger Institute, Wellcome Genome Campus, Hinxton, CB10 1SA, UK.<br /><searchLink fieldCode="AU" term="%22Malawsky+DS%22">Malawsky DS</searchLink>; Human Genetics Programme, Wellcome Sanger Institute, Wellcome Genome Campus, Hinxton, CB10 1SA, UK.<br /><searchLink fieldCode="AU" term="%22Wade+EM%22">Wade EM</searchLink>; Human Genetics Programme, Wellcome Sanger Institute, Wellcome Genome Campus, Hinxton, CB10 1SA, UK.<br /><searchLink fieldCode="AU" term="%22Verhoef+E%22">Verhoef E</searchLink>; Language and Genetics Department, Max Planck Institute for Psycholinguistics, Nijmegen, The Netherlands.<br /><searchLink fieldCode="AU" term="%22Gui+A%22">Gui A</searchLink>; Department of Systems Medicine, University of Rome Tor Vergata, via Montpellier 1, 00133 Rome, Italy.; Centre for Brain and Cognitive Development, Department of Psychological Sciences, Birkbeck University of London, London, WC1E 7HX, United Kingdom.<br /><searchLink fieldCode="AU" term="%22Hegemann+L%22">Hegemann L</searchLink>; Research Department, Lovisenberg Diaconal Hospital, Oslo, Norway.; PsychGen Centre for Genetic Epidemiology and Mental Health, Norwegian Institute of Public Health, Oslo, Norway.<br /><searchLink fieldCode="AU" term="%22Geschwind+DH%22">Geschwind DH</searchLink>; Program in Neurobehavioral Genetics and Center for Autism Research and Treatment, Semel Institute, David Geffen School of Medicine, University of California, Los Angeles, Los Angeles, CA 90095, USA.; Program in Neurogenetics, Department of Neurology, David Geffen School of Medicine, University of California, Los Angeles, Los Angeles, CA 90095, USA.; Department of Psychiatry, Semel Institute, David Geffen School of Medicine, University of California, Los Angeles, Los Angeles, CA 90095, USA.; Department of Human Genetics, David Geffen School of Medicine, University of California, Los Angeles, Los Angeles, CA 90095, USA.<br /><searchLink fieldCode="AU" term="%22Wray+NR%22">Wray NR</searchLink>; Institute for Molecular Bioscience, University of Queensland, Brisbane, QLD 4072, Australia.; Department of Psychiatry, University of Oxford, Oxford, OX3 7JX, United Kingdom.<br /><searchLink fieldCode="AU" term="%22Havdahl+A%22">Havdahl A</searchLink>; Research Department, Lovisenberg Diaconal Hospital, Oslo, Norway.; PsychGen Centre for Genetic Epidemiology and Mental Health, Norwegian Institute of Public Health, Oslo, Norway.; Promenta Research Centre, Department of Psychology, University of Oslo, Oslo, Norway.<br /><searchLink fieldCode="AU" term="%22Ronald+A%22">Ronald A</searchLink>; Centre for Brain and Cognitive Development, Department of Psychological Sciences, Birkbeck University of London, London, WC1E 7HX, United Kingdom.; School of Psychology, University of Surrey, Guildford, Surrey, GU2 7XH, United Kingdom.<br /><searchLink fieldCode="AU" term="%22St+Pourcain+B%22">St Pourcain B</searchLink>; Language and Genetics Department, Max Planck Institute for Psycholinguistics, Nijmegen, The Netherlands.; MRC Integrative Epidemiology Unit, University of Bristol, United Kingdom.; Donders Institute for Brain, Cognition and Behaviour, Radboud University, The Netherlands.<br /><searchLink fieldCode="AU" term="%22Robinson+EB%22">Robinson EB</searchLink>; Center for Genomic Medicine, Massachusetts General Hospital, Boston, MA, USA.; The Broad Institute of MIT and Harvard, Cambridge, MA, USA.<br /><searchLink fieldCode="AU" term="%22Bourgeron+T%22">Bourgeron T</searchLink>; Human Genetics and Cognitive Functions, Institut Pasteur, UMR3571 CNRS, IUF, Université Paris Cité, Paris, France.<br /><searchLink fieldCode="AU" term="%22Baron-Cohen+S%22">Baron-Cohen S</searchLink>; Department of Psychiatry, University of Cambridge.; Autism Research Centre, Department of Psychiatry, University of Cambridge, Cambridge, UK.; Department of Psychology, University of Cambridge, Cambridge, UK.<br /><searchLink fieldCode="AU" term="%22Børglum+AD%22">Børglum AD</searchLink>; The Lundbeck Foundation Initiative for Integrative Psychiatric Research, iPSYCH, Aarhus, Denmark.; Center for Genomics and Personalized Medicine (CGPM), Aarhus University, Aarhus, Denmark.; Department of Biomedicine (Human Genetics) and iSEQ Center, Aarhus University, Aarhus, Denmark.<br /><searchLink fieldCode="AU" term="%22Martin+HC%22">Martin HC</searchLink>; Human Genetics Programme, Wellcome Sanger Institute, Wellcome Genome Campus, Hinxton, CB10 1SA, UK.<br /><searchLink fieldCode="AU" term="%22Warrier+V%22">Warrier V</searchLink>; Department of Psychiatry, University of Cambridge.; Autism Research Centre, Department of Psychiatry, University of Cambridge, Cambridge, UK.; Department of Psychology, University of Cambridge, Cambridge, UK.
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