GRK2 kinases in the primary cilium initiate SMOOTHENED-PKA signaling in the Hedgehog cascade.
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| Title: | GRK2 kinases in the primary cilium initiate SMOOTHENED-PKA signaling in the Hedgehog cascade. |
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| Authors: | Walker MF; Department of Oncological Sciences, Huntsman Cancer Institute, University of Utah School of Medicine, Salt Lake City, Utah, United States of America.; Department of Biochemistry, University of Utah School of Medicine, Salt Lake City, Utah, United States of America.; Department of Bioengineering, University of Utah School of Medicine, Salt Lake City, Utah, United States of America., Zhang J; Department of Molecular and Cell Biology, School of Natural Sciences, University of California, Merced, California, United States of America., Steiner W; Department of Oncological Sciences, Huntsman Cancer Institute, University of Utah School of Medicine, Salt Lake City, Utah, United States of America.; Department of Biochemistry, University of Utah School of Medicine, Salt Lake City, Utah, United States of America.; Department of Bioengineering, University of Utah School of Medicine, Salt Lake City, Utah, United States of America., Ku PI; Department of Molecular Biology, Massachusetts General Hospital, Boston, Massachusetts, USA; Department of Genetics, Harvard Medical School, Boston, Massachusetts, United States of America., Zhu JF; Department of Oncological Sciences, Huntsman Cancer Institute, University of Utah School of Medicine, Salt Lake City, Utah, United States of America.; Department of Biochemistry, University of Utah School of Medicine, Salt Lake City, Utah, United States of America.; Department of Bioengineering, University of Utah School of Medicine, Salt Lake City, Utah, United States of America., Michaelson Z; Department of Oncological Sciences, Huntsman Cancer Institute, University of Utah School of Medicine, Salt Lake City, Utah, United States of America.; Department of Biochemistry, University of Utah School of Medicine, Salt Lake City, Utah, United States of America.; Department of Bioengineering, University of Utah School of Medicine, Salt Lake City, Utah, United States of America., Yen YC; Department of Biological Sciences, Purdue University, West Lafayette, Indiana, United States of America., Lee A; Department of Oncological Sciences, Huntsman Cancer Institute, University of Utah School of Medicine, Salt Lake City, Utah, United States of America.; Department of Biochemistry, University of Utah School of Medicine, Salt Lake City, Utah, United States of America.; Department of Bioengineering, University of Utah School of Medicine, Salt Lake City, Utah, United States of America., Long AB; Department of Human Genetics, Emory University School of Medicine, Atlanta, Georgia, United States of America., Casey MJ; Department of Oncological Sciences, Huntsman Cancer Institute, University of Utah School of Medicine, Salt Lake City, Utah, United States of America., Poddar A; Department of Molecular Biology, Massachusetts General Hospital, Boston, Massachusetts, USA; Department of Genetics, Harvard Medical School, Boston, Massachusetts, United States of America., Nelson IB; Department of Oncological Sciences, Huntsman Cancer Institute, University of Utah School of Medicine, Salt Lake City, Utah, United States of America.; Department of Biochemistry, University of Utah School of Medicine, Salt Lake City, Utah, United States of America.; Department of Bioengineering, University of Utah School of Medicine, Salt Lake City, Utah, United States of America., Arveseth CD; Department of Oncological Sciences, Huntsman Cancer Institute, University of Utah School of Medicine, Salt Lake City, Utah, United States of America.; Department of Biochemistry, University of Utah School of Medicine, Salt Lake City, Utah, United States of America.; Department of Bioengineering, University of Utah School of Medicine, Salt Lake City, Utah, United States of America., Nagel F; 7TM Antibodies GmbH, Jena, Germany., Clough R; Department of Human Genetics, University of Utah School of Medicine, Salt Lake City, Utah, United States of America., LaPotin S; Department of Human Genetics, University of Utah School of Medicine, Salt Lake City, Utah, United States of America., Kwan KM; Department of Human Genetics, University of Utah School of Medicine, Salt Lake City, Utah, United States of America., Schulz S; 7TM Antibodies GmbH, Jena, Germany.; Institute of Pharmacology and Toxicology, University Hospital Jena, Jena, Germany., Stewart RA; Department of Oncological Sciences, Huntsman Cancer Institute, University of Utah School of Medicine, Salt Lake City, Utah, United States of America., Tesmer JJG; Department of Biological Sciences, Purdue University, West Lafayette, Indiana, United States of America.; Department of Medicinal Chemistry and Molecular Pharmacology, Purdue University, West Lafayette, Indiana, United States of America., Caspary T; Department of Human Genetics, Emory University School of Medicine, Atlanta, Georgia, United States of America., Subramanian R; Department of Molecular Biology, Massachusetts General Hospital, Boston, Massachusetts, USA; Department of Genetics, Harvard Medical School, Boston, Massachusetts, United States of America., Ge X; Department of Molecular and Cell Biology, School of Natural Sciences, University of California, Merced, California, United States of America., Myers BR; Department of Oncological Sciences, Huntsman Cancer Institute, University of Utah School of Medicine, Salt Lake City, Utah, United States of America.; Department of Biochemistry, University of Utah School of Medicine, Salt Lake City, Utah, United States of America.; Department of Bioengineering, University of Utah School of Medicine, Salt Lake City, Utah, United States of America. |
| Source: | PLoS biology [PLoS Biol] 2024 Aug 13; Vol. 22 (8), pp. e3002685. Date of Electronic Publication: 2024 Aug 13 (Print Publication: 2024). |
| Publication Type: | Journal Article |
| Journal Info: | Publisher: Public Library of Science Country of Publication: United States NLM ID: 101183755 Publication Model: eCollection Cited Medium: Internet ISSN: 1545-7885 (Electronic) Linking ISSN: 15449173 NLM ISO Abbreviation: PLoS Biol Subsets: MEDLINE |
| Database: | MEDLINE Ultimate |
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| ISSN: | 1545-7885 |
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| DOI: | 10.1371/journal.pbio.3002685 |
