GRK2 kinases in the primary cilium initiate SMOOTHENED-PKA signaling in the Hedgehog cascade.
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| Title: | GRK2 kinases in the primary cilium initiate SMOOTHENED-PKA signaling in the Hedgehog cascade. |
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| Authors: | Walker MF; Department of Oncological Sciences, Huntsman Cancer Institute, University of Utah School of Medicine, Salt Lake City, Utah, United States of America.; Department of Biochemistry, University of Utah School of Medicine, Salt Lake City, Utah, United States of America.; Department of Bioengineering, University of Utah School of Medicine, Salt Lake City, Utah, United States of America., Zhang J; Department of Molecular and Cell Biology, School of Natural Sciences, University of California, Merced, California, United States of America., Steiner W; Department of Oncological Sciences, Huntsman Cancer Institute, University of Utah School of Medicine, Salt Lake City, Utah, United States of America.; Department of Biochemistry, University of Utah School of Medicine, Salt Lake City, Utah, United States of America.; Department of Bioengineering, University of Utah School of Medicine, Salt Lake City, Utah, United States of America., Ku PI; Department of Molecular Biology, Massachusetts General Hospital, Boston, Massachusetts, USA; Department of Genetics, Harvard Medical School, Boston, Massachusetts, United States of America., Zhu JF; Department of Oncological Sciences, Huntsman Cancer Institute, University of Utah School of Medicine, Salt Lake City, Utah, United States of America.; Department of Biochemistry, University of Utah School of Medicine, Salt Lake City, Utah, United States of America.; Department of Bioengineering, University of Utah School of Medicine, Salt Lake City, Utah, United States of America., Michaelson Z; Department of Oncological Sciences, Huntsman Cancer Institute, University of Utah School of Medicine, Salt Lake City, Utah, United States of America.; Department of Biochemistry, University of Utah School of Medicine, Salt Lake City, Utah, United States of America.; Department of Bioengineering, University of Utah School of Medicine, Salt Lake City, Utah, United States of America., Yen YC; Department of Biological Sciences, Purdue University, West Lafayette, Indiana, United States of America., Lee A; Department of Oncological Sciences, Huntsman Cancer Institute, University of Utah School of Medicine, Salt Lake City, Utah, United States of America.; Department of Biochemistry, University of Utah School of Medicine, Salt Lake City, Utah, United States of America.; Department of Bioengineering, University of Utah School of Medicine, Salt Lake City, Utah, United States of America., Long AB; Department of Human Genetics, Emory University School of Medicine, Atlanta, Georgia, United States of America., Casey MJ; Department of Oncological Sciences, Huntsman Cancer Institute, University of Utah School of Medicine, Salt Lake City, Utah, United States of America., Poddar A; Department of Molecular Biology, Massachusetts General Hospital, Boston, Massachusetts, USA; Department of Genetics, Harvard Medical School, Boston, Massachusetts, United States of America., Nelson IB; Department of Oncological Sciences, Huntsman Cancer Institute, University of Utah School of Medicine, Salt Lake City, Utah, United States of America.; Department of Biochemistry, University of Utah School of Medicine, Salt Lake City, Utah, United States of America.; Department of Bioengineering, University of Utah School of Medicine, Salt Lake City, Utah, United States of America., Arveseth CD; Department of Oncological Sciences, Huntsman Cancer Institute, University of Utah School of Medicine, Salt Lake City, Utah, United States of America.; Department of Biochemistry, University of Utah School of Medicine, Salt Lake City, Utah, United States of America.; Department of Bioengineering, University of Utah School of Medicine, Salt Lake City, Utah, United States of America., Nagel F; 7TM Antibodies GmbH, Jena, Germany., Clough R; Department of Human Genetics, University of Utah School of Medicine, Salt Lake City, Utah, United States of America., LaPotin S; Department of Human Genetics, University of Utah School of Medicine, Salt Lake City, Utah, United States of America., Kwan KM; Department of Human Genetics, University of Utah School of Medicine, Salt Lake City, Utah, United States of America., Schulz S; 7TM Antibodies GmbH, Jena, Germany.; Institute of Pharmacology and Toxicology, University Hospital Jena, Jena, Germany., Stewart RA; Department of Oncological Sciences, Huntsman Cancer Institute, University of Utah School of Medicine, Salt Lake City, Utah, United States of America., Tesmer JJG; Department of Biological Sciences, Purdue University, West Lafayette, Indiana, United States of America.; Department of Medicinal Chemistry and Molecular Pharmacology, Purdue University, West Lafayette, Indiana, United States of America., Caspary T; Department of Human Genetics, Emory University School of Medicine, Atlanta, Georgia, United States of America., Subramanian R; Department of Molecular Biology, Massachusetts General Hospital, Boston, Massachusetts, USA; Department of Genetics, Harvard Medical School, Boston, Massachusetts, United States of America., Ge X; Department of Molecular and Cell Biology, School of Natural Sciences, University of California, Merced, California, United States of America., Myers BR; Department of Oncological Sciences, Huntsman Cancer Institute, University of Utah School of Medicine, Salt Lake City, Utah, United States of America.; Department of Biochemistry, University of Utah School of Medicine, Salt Lake City, Utah, United States of America.; Department of Bioengineering, University of Utah School of Medicine, Salt Lake City, Utah, United States of America. |
| Source: | PLoS biology [PLoS Biol] 2024 Aug 13; Vol. 22 (8), pp. e3002685. Date of Electronic Publication: 2024 Aug 13 (Print Publication: 2024). |
| Publication Type: | Journal Article |
| Journal Info: | Publisher: Public Library of Science Country of Publication: United States NLM ID: 101183755 Publication Model: eCollection Cited Medium: Internet ISSN: 1545-7885 (Electronic) Linking ISSN: 15449173 NLM ISO Abbreviation: PLoS Biol Subsets: MEDLINE |
| Database: | MEDLINE Ultimate |
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| Header | DbId: mdl DbLabel: MEDLINE Ultimate An: 39138140 AccessLevel: 2 PubType: Academic Journal PubTypeId: academicJournal PreciseRelevancyScore: 0 |
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| Items | – Name: Title Label: Title Group: Ti Data: GRK2 kinases in the primary cilium initiate SMOOTHENED-PKA signaling in the Hedgehog cascade. – Name: Author Label: Authors Group: Au Data: <searchLink fieldCode="AU" term="%22Walker+MF%22">Walker MF</searchLink>; Department of Oncological Sciences, Huntsman Cancer Institute, University of Utah School of Medicine, Salt Lake City, Utah, United States of America.; Department of Biochemistry, University of Utah School of Medicine, Salt Lake City, Utah, United States of America.; Department of Bioengineering, University of Utah School of Medicine, Salt Lake City, Utah, United States of America.<br /><searchLink fieldCode="AU" term="%22Zhang+J%22">Zhang J</searchLink>; Department of Molecular and Cell Biology, School of Natural Sciences, University of California, Merced, California, United States of America.<br /><searchLink fieldCode="AU" term="%22Steiner+W%22">Steiner W</searchLink>; Department of Oncological Sciences, Huntsman Cancer Institute, University of Utah School of Medicine, Salt Lake City, Utah, United States of America.; Department of Biochemistry, University of Utah School of Medicine, Salt Lake City, Utah, United States of America.; Department of Bioengineering, University of Utah School of Medicine, Salt Lake City, Utah, United States of America.<br /><searchLink fieldCode="AU" term="%22Ku+PI%22">Ku PI</searchLink>; Department of Molecular Biology, Massachusetts General Hospital, Boston, Massachusetts, USA; Department of Genetics, Harvard Medical School, Boston, Massachusetts, United States of America.<br /><searchLink fieldCode="AU" term="%22Zhu+JF%22">Zhu JF</searchLink>; Department of Oncological Sciences, Huntsman Cancer Institute, University of Utah School of Medicine, Salt Lake City, Utah, United States of America.; Department of Biochemistry, University of Utah School of Medicine, Salt Lake City, Utah, United States of America.; Department of Bioengineering, University of Utah School of Medicine, Salt Lake City, Utah, United States of America.<br /><searchLink fieldCode="AU" term="%22Michaelson+Z%22">Michaelson Z</searchLink>; Department of Oncological Sciences, Huntsman Cancer Institute, University of Utah School of Medicine, Salt Lake City, Utah, United States of America.; Department of Biochemistry, University of Utah School of Medicine, Salt Lake City, Utah, United States of America.; Department of Bioengineering, University of Utah School of Medicine, Salt Lake City, Utah, United States of America.<br /><searchLink fieldCode="AU" term="%22Yen+YC%22">Yen YC</searchLink>; Department of Biological Sciences, Purdue University, West Lafayette, Indiana, United States of America.<br /><searchLink fieldCode="AU" term="%22Lee+A%22">Lee A</searchLink>; Department of Oncological Sciences, Huntsman Cancer Institute, University of Utah School of Medicine, Salt Lake City, Utah, United States of America.; Department of Biochemistry, University of Utah School of Medicine, Salt Lake City, Utah, United States of America.; Department of Bioengineering, University of Utah School of Medicine, Salt Lake City, Utah, United States of America.<br /><searchLink fieldCode="AU" term="%22Long+AB%22">Long AB</searchLink>; Department of Human Genetics, Emory University School of Medicine, Atlanta, Georgia, United States of America.<br /><searchLink fieldCode="AU" term="%22Casey+MJ%22">Casey MJ</searchLink>; Department of Oncological Sciences, Huntsman Cancer Institute, University of Utah School of Medicine, Salt Lake City, Utah, United States of America.<br /><searchLink fieldCode="AU" term="%22Poddar+A%22">Poddar A</searchLink>; Department of Molecular Biology, Massachusetts General Hospital, Boston, Massachusetts, USA; Department of Genetics, Harvard Medical School, Boston, Massachusetts, United States of America.<br /><searchLink fieldCode="AU" term="%22Nelson+IB%22">Nelson IB</searchLink>; Department of Oncological Sciences, Huntsman Cancer Institute, University of Utah School of Medicine, Salt Lake City, Utah, United States of America.; Department of Biochemistry, University of Utah School of Medicine, Salt Lake City, Utah, United States of America.; Department of Bioengineering, University of Utah School of Medicine, Salt Lake City, Utah, United States of America.<br /><searchLink fieldCode="AU" term="%22Arveseth+CD%22">Arveseth CD</searchLink>; Department of Oncological Sciences, Huntsman Cancer Institute, University of Utah School of Medicine, Salt Lake City, Utah, United States of America.; Department of Biochemistry, University of Utah School of Medicine, Salt Lake City, Utah, United States of America.; Department of Bioengineering, University of Utah School of Medicine, Salt Lake City, Utah, United States of America.<br /><searchLink fieldCode="AU" term="%22Nagel+F%22">Nagel F</searchLink>; 7TM Antibodies GmbH, Jena, Germany.<br /><searchLink fieldCode="AU" term="%22Clough+R%22">Clough R</searchLink>; Department of Human Genetics, University of Utah School of Medicine, Salt Lake City, Utah, United States of America.<br /><searchLink fieldCode="AU" term="%22LaPotin+S%22">LaPotin S</searchLink>; Department of Human Genetics, University of Utah School of Medicine, Salt Lake City, Utah, United States of America.<br /><searchLink fieldCode="AU" term="%22Kwan+KM%22">Kwan KM</searchLink>; Department of Human Genetics, University of Utah School of Medicine, Salt Lake City, Utah, United States of America.<br /><searchLink fieldCode="AU" term="%22Schulz+S%22">Schulz S</searchLink>; 7TM Antibodies GmbH, Jena, Germany.; Institute of Pharmacology and Toxicology, University Hospital Jena, Jena, Germany.<br /><searchLink fieldCode="AU" term="%22Stewart+RA%22">Stewart RA</searchLink>; Department of Oncological Sciences, Huntsman Cancer Institute, University of Utah School of Medicine, Salt Lake City, Utah, United States of America.<br /><searchLink fieldCode="AU" term="%22Tesmer+JJG%22">Tesmer JJG</searchLink>; Department of Biological Sciences, Purdue University, West Lafayette, Indiana, United States of America.; Department of Medicinal Chemistry and Molecular Pharmacology, Purdue University, West Lafayette, Indiana, United States of America.<br /><searchLink fieldCode="AU" term="%22Caspary+T%22">Caspary T</searchLink>; Department of Human Genetics, Emory University School of Medicine, Atlanta, Georgia, United States of America.<br /><searchLink fieldCode="AU" term="%22Subramanian+R%22">Subramanian R</searchLink>; Department of Molecular Biology, Massachusetts General Hospital, Boston, Massachusetts, USA; Department of Genetics, Harvard Medical School, Boston, Massachusetts, United States of America.<br /><searchLink fieldCode="AU" term="%22Ge+X%22">Ge X</searchLink>; Department of Molecular and Cell Biology, School of Natural Sciences, University of California, Merced, California, United States of America.<br /><searchLink fieldCode="AU" term="%22Myers+BR%22">Myers BR</searchLink>; Department of Oncological Sciences, Huntsman Cancer Institute, University of Utah School of Medicine, Salt Lake City, Utah, United States of America.; Department of Biochemistry, University of Utah School of Medicine, Salt Lake City, Utah, United States of America.; Department of Bioengineering, University of Utah School of Medicine, Salt Lake City, Utah, United States of America. – Name: TitleSource Label: Source Group: Src Data: <searchLink fieldCode="JN" term="%22101183755%22">PLoS biology</searchLink> [PLoS Biol] 2024 Aug 13; Vol. 22 (8), pp. e3002685. <i>Date of Electronic Publication: </i>2024 Aug 13 (<i>Print Publication: </i>2024). – Name: TypePub Label: Publication Type Group: TypPub Data: Journal Article – Name: TitleSource Label: Journal Info Group: Src Data: <i>Publisher: </i><searchLink fieldCode="PB" term="%22Public+Library+of+Science%22">Public Library of Science </searchLink><i>Country of Publication: </i>United States <i>NLM ID: </i>101183755 <i>Publication Model: </i>eCollection <i>Cited Medium: </i>Internet <i>ISSN: </i>1545-7885 (Electronic) <i>Linking ISSN: </i><searchLink fieldCode="IS" term="%2215449173%22">15449173 </searchLink><i>NLM ISO Abbreviation: </i>PLoS Biol <i>Subsets: </i>MEDLINE |
| PLink | https://search.ebscohost.com/login.aspx?direct=true&site=eds-live&db=mdl&AN=39138140 |
| RecordInfo | BibRecord: BibEntity: Identifiers: – Type: doi Value: 10.1371/journal.pbio.3002685 Languages: – Code: eng Text: English PhysicalDescription: Pagination: StartPage: e3002685 Titles: – TitleFull: GRK2 kinases in the primary cilium initiate SMOOTHENED-PKA signaling in the Hedgehog cascade. Type: main BibRelationships: HasContributorRelationships: – PersonEntity: Name: NameFull: Walker MF – PersonEntity: Name: NameFull: Zhang J – PersonEntity: Name: NameFull: Steiner W – PersonEntity: Name: NameFull: Ku PI – PersonEntity: Name: NameFull: Zhu JF – PersonEntity: Name: NameFull: Michaelson Z – PersonEntity: Name: NameFull: Yen YC – PersonEntity: Name: NameFull: Lee A – PersonEntity: Name: NameFull: Long AB – PersonEntity: Name: NameFull: Casey MJ – PersonEntity: Name: NameFull: Poddar A – PersonEntity: Name: NameFull: Nelson IB – PersonEntity: Name: NameFull: Arveseth CD – PersonEntity: Name: NameFull: Nagel F – PersonEntity: Name: NameFull: Clough R – PersonEntity: Name: NameFull: LaPotin S – PersonEntity: Name: NameFull: Kwan KM – PersonEntity: Name: NameFull: Schulz S – PersonEntity: Name: NameFull: Stewart RA – PersonEntity: Name: NameFull: Tesmer JJG – PersonEntity: Name: NameFull: Caspary T – PersonEntity: Name: NameFull: Subramanian R – PersonEntity: Name: NameFull: Ge X – PersonEntity: Name: NameFull: Myers BR IsPartOfRelationships: – BibEntity: Dates: – D: 13 M: 08 Text: 2024 Aug 13 Type: published Y: 2024 Identifiers: – Type: issn-electronic Value: 1545-7885 Numbering: – Type: volume Value: 22 – Type: issue Value: 8 Titles: – TitleFull: PLoS biology Type: main |
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