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The role of venous capacity in fluid retention with endothelin A antagonism: Mathematical modelling of the RADAR trial.

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Title: The role of venous capacity in fluid retention with endothelin A antagonism: Mathematical modelling of the RADAR trial.
Authors: Yu H; Clinical Pharmacology and Quantitative Pharmacology, Clinical Pharmacology and Safety Sciences, BioPharmaceuticals R&D, AstraZeneca, Gaithersburg, Maryland, USA., Greasley PJ; Early Clinical Development, Research and Early Development, Cardiovascular, Renal and Metabolism, BioPharmaceuticals R&D, AstraZeneca, Gothenburg, Sweden., Lambers Heerspink HJ; Department of Clinical Pharmacy and Pharmacology, University of Groningen, Groningen, The Netherlands.; The George Institute for Global Health, Sydney, Australia., Ambery P; Late-stage Development, Cardiovascular, Renal and Metabolism, BioPharmaceuticals R&D, AstraZeneca, Gothenburg, Sweden., Ahlstrom C; Drug Metabolism and Pharmacokinetics, Research and Early Development, Cardiovascular, Renal and Metabolism, BioPharmaceuticals R&D, AstraZeneca, Gothenburg, Sweden., Hamren B; Clinical Pharmacology and Quantitative Pharmacology, Clinical Pharmacology and Safety Sciences, R&D, AstraZeneca, Gothenburg, Sweden., Khan AA; Clinical Pharmacology and Quantitative Pharmacology, Clinical Pharmacology and Safety Sciences, BioPharmaceuticals R&D, AstraZeneca, Gaithersburg, Maryland, USA., Boulton DW; Clinical Pharmacology and Quantitative Pharmacology, Clinical Pharmacology and Safety Sciences, BioPharmaceuticals R&D, AstraZeneca, Gaithersburg, Maryland, USA., Hallow KM; School of Chemical, Materials, and Biomedical Engineering, University of Georgia, Athens, Georgia, USA.; Department of Epidemiology and Biostatistics, University of Georgia, Athens, Georgia, USA.
Source: British journal of pharmacology [Br J Pharmacol] 2024 Nov; Vol. 181 (22), pp. 4693-4707. Date of Electronic Publication: 2024 Aug 19.
Publication Type: Journal Article; Randomized Controlled Trial
Journal Info: Publisher: Wiley Country of Publication: England NLM ID: 7502536 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1476-5381 (Electronic) Linking ISSN: 00071188 NLM ISO Abbreviation: Br J Pharmacol Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: The role of venous capacity in fluid retention with endothelin A antagonism: Mathematical modelling of the RADAR trial.
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  Data: <searchLink fieldCode="AU" term="%22Yu+H%22">Yu H</searchLink>; Clinical Pharmacology and Quantitative Pharmacology, Clinical Pharmacology and Safety Sciences, BioPharmaceuticals R&D, AstraZeneca, Gaithersburg, Maryland, USA.<br /><searchLink fieldCode="AU" term="%22Greasley+PJ%22">Greasley PJ</searchLink>; Early Clinical Development, Research and Early Development, Cardiovascular, Renal and Metabolism, BioPharmaceuticals R&D, AstraZeneca, Gothenburg, Sweden.<br /><searchLink fieldCode="AU" term="%22Lambers+Heerspink+HJ%22">Lambers Heerspink HJ</searchLink>; Department of Clinical Pharmacy and Pharmacology, University of Groningen, Groningen, The Netherlands.; The George Institute for Global Health, Sydney, Australia.<br /><searchLink fieldCode="AU" term="%22Ambery+P%22">Ambery P</searchLink>; Late-stage Development, Cardiovascular, Renal and Metabolism, BioPharmaceuticals R&D, AstraZeneca, Gothenburg, Sweden.<br /><searchLink fieldCode="AU" term="%22Ahlstrom+C%22">Ahlstrom C</searchLink>; Drug Metabolism and Pharmacokinetics, Research and Early Development, Cardiovascular, Renal and Metabolism, BioPharmaceuticals R&D, AstraZeneca, Gothenburg, Sweden.<br /><searchLink fieldCode="AU" term="%22Hamren+B%22">Hamren B</searchLink>; Clinical Pharmacology and Quantitative Pharmacology, Clinical Pharmacology and Safety Sciences, R&D, AstraZeneca, Gothenburg, Sweden.<br /><searchLink fieldCode="AU" term="%22Khan+AA%22">Khan AA</searchLink>; Clinical Pharmacology and Quantitative Pharmacology, Clinical Pharmacology and Safety Sciences, BioPharmaceuticals R&D, AstraZeneca, Gaithersburg, Maryland, USA.<br /><searchLink fieldCode="AU" term="%22Boulton+DW%22">Boulton DW</searchLink>; Clinical Pharmacology and Quantitative Pharmacology, Clinical Pharmacology and Safety Sciences, BioPharmaceuticals R&D, AstraZeneca, Gaithersburg, Maryland, USA.<br /><searchLink fieldCode="AU" term="%22Hallow+KM%22">Hallow KM</searchLink>; School of Chemical, Materials, and Biomedical Engineering, University of Georgia, Athens, Georgia, USA.; Department of Epidemiology and Biostatistics, University of Georgia, Athens, Georgia, USA.
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  Data: <searchLink fieldCode="JN" term="%227502536%22">British journal of pharmacology</searchLink> [Br J Pharmacol] 2024 Nov; Vol. 181 (22), pp. 4693-4707. <i>Date of Electronic Publication: </i>2024 Aug 19.
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  Data: <i>Publisher: </i><searchLink fieldCode="PB" term="%22Wiley%22">Wiley </searchLink><i>Country of Publication: </i>England <i>NLM ID: </i>7502536 <i>Publication Model: </i>Print-Electronic <i>Cited Medium: </i>Internet <i>ISSN: </i>1476-5381 (Electronic) <i>Linking ISSN: </i><searchLink fieldCode="IS" term="%2200071188%22">00071188 </searchLink><i>NLM ISO Abbreviation: </i>Br J Pharmacol <i>Subsets: </i>MEDLINE
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              Text: 2024 Nov
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