A Novel Confocal Scanning Protein-Protein Interaction Assay (PPI-CONA) Reveals Exceptional Selectivity and Specificity of CC0651, a Small Molecule Binding Enhancer of the Weak Interaction between the E2 Ubiquitin-Conjugating Enzyme CDC34A and Ubiquitin.

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Title: A Novel Confocal Scanning Protein-Protein Interaction Assay (PPI-CONA) Reveals Exceptional Selectivity and Specificity of CC0651, a Small Molecule Binding Enhancer of the Weak Interaction between the E2 Ubiquitin-Conjugating Enzyme CDC34A and Ubiquitin.
Authors: Koszela J; School of Molecular Biosciences, University of Glasgow, Glasgow G12 8QQ, U.K., Pham NT; School of Biological Sciences, University of Edinburgh, Edinburgh, Scotland EH9 3BF, U.K.; College of Medicine and Veterinary Medicine, Institute for Regeneration and Repair, University of Edinburgh, 4-5 Little France Drive, Edinburgh EH16 4UU, U.K., Shave S; School of Biological Sciences, University of Edinburgh, Edinburgh, Scotland EH9 3BF, U.K.; Edinburgh Cancer Research, Cancer Research UK Scotland Centre, Institute of Genetics and Cancer, University of Edinburgh, Crewe Road South, Edinburgh EH4 2XR, U.K., St-Cyr D; X-Chem Inc., Montréal, Québec H4S 1Z9, Canada.; Institute for Research in Immunology and Cancer, University of Montreal, Montreal, Québec H3T 1J4, Canada., Ceccarelli DF; Centre for Systems Biology, Lunenfeld-Tanenbaum Research Institute, Mount Sinai Hospital, Toronto, Ontario M5G 1X5, Canada., Orlicky S; Centre for Systems Biology, Lunenfeld-Tanenbaum Research Institute, Mount Sinai Hospital, Toronto, Ontario M5G 1X5, Canada., Marinier A; Institute for Research in Immunology and Cancer, University of Montreal, Montreal, Québec H3T 1J4, Canada., Sicheri F; Centre for Systems Biology, Lunenfeld-Tanenbaum Research Institute, Mount Sinai Hospital, Toronto, Ontario M5G 1X5, Canada., Tyers M; Institute for Research in Immunology and Cancer, University of Montreal, Montreal, Québec H3T 1J4, Canada.; Program in Molecular Medicine, The Hospital for Sick Children, Toronto, Ontario M5G 0A4, Canada., Auer M; School of Biological Sciences, University of Edinburgh, Edinburgh, Scotland EH9 3BF, U.K.
Source: Bioconjugate chemistry [Bioconjug Chem] 2024 Sep 18; Vol. 35 (9), pp. 1441-1449. Date of Electronic Publication: 2024 Aug 21.
Publication Type: Journal Article; Research Support, Non-U.S. Gov't
Journal Info: Publisher: American Chemical Society Country of Publication: United States NLM ID: 9010319 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1520-4812 (Electronic) Linking ISSN: 10431802 NLM ISO Abbreviation: Bioconjug Chem Subsets: MEDLINE
Database: MEDLINE Ultimate
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ISSN:1520-4812
DOI:10.1021/acs.bioconjchem.4c00345