A Novel Confocal Scanning Protein-Protein Interaction Assay (PPI-CONA) Reveals Exceptional Selectivity and Specificity of CC0651, a Small Molecule Binding Enhancer of the Weak Interaction between the E2 Ubiquitin-Conjugating Enzyme CDC34A and Ubiquitin.
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| Title: | A Novel Confocal Scanning Protein-Protein Interaction Assay (PPI-CONA) Reveals Exceptional Selectivity and Specificity of CC0651, a Small Molecule Binding Enhancer of the Weak Interaction between the E2 Ubiquitin-Conjugating Enzyme CDC34A and Ubiquitin. |
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| Authors: | Koszela J; School of Molecular Biosciences, University of Glasgow, Glasgow G12 8QQ, U.K., Pham NT; School of Biological Sciences, University of Edinburgh, Edinburgh, Scotland EH9 3BF, U.K.; College of Medicine and Veterinary Medicine, Institute for Regeneration and Repair, University of Edinburgh, 4-5 Little France Drive, Edinburgh EH16 4UU, U.K., Shave S; School of Biological Sciences, University of Edinburgh, Edinburgh, Scotland EH9 3BF, U.K.; Edinburgh Cancer Research, Cancer Research UK Scotland Centre, Institute of Genetics and Cancer, University of Edinburgh, Crewe Road South, Edinburgh EH4 2XR, U.K., St-Cyr D; X-Chem Inc., Montréal, Québec H4S 1Z9, Canada.; Institute for Research in Immunology and Cancer, University of Montreal, Montreal, Québec H3T 1J4, Canada., Ceccarelli DF; Centre for Systems Biology, Lunenfeld-Tanenbaum Research Institute, Mount Sinai Hospital, Toronto, Ontario M5G 1X5, Canada., Orlicky S; Centre for Systems Biology, Lunenfeld-Tanenbaum Research Institute, Mount Sinai Hospital, Toronto, Ontario M5G 1X5, Canada., Marinier A; Institute for Research in Immunology and Cancer, University of Montreal, Montreal, Québec H3T 1J4, Canada., Sicheri F; Centre for Systems Biology, Lunenfeld-Tanenbaum Research Institute, Mount Sinai Hospital, Toronto, Ontario M5G 1X5, Canada., Tyers M; Institute for Research in Immunology and Cancer, University of Montreal, Montreal, Québec H3T 1J4, Canada.; Program in Molecular Medicine, The Hospital for Sick Children, Toronto, Ontario M5G 0A4, Canada., Auer M; School of Biological Sciences, University of Edinburgh, Edinburgh, Scotland EH9 3BF, U.K. |
| Source: | Bioconjugate chemistry [Bioconjug Chem] 2024 Sep 18; Vol. 35 (9), pp. 1441-1449. Date of Electronic Publication: 2024 Aug 21. |
| Publication Type: | Journal Article; Research Support, Non-U.S. Gov't |
| Journal Info: | Publisher: American Chemical Society Country of Publication: United States NLM ID: 9010319 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1520-4812 (Electronic) Linking ISSN: 10431802 NLM ISO Abbreviation: Bioconjug Chem Subsets: MEDLINE |
| Database: | MEDLINE Ultimate |
| FullText | Text: Availability: 0 |
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| Header | DbId: mdl DbLabel: MEDLINE Ultimate An: 39167708 AccessLevel: 2 PubType: Academic Journal PubTypeId: academicJournal PreciseRelevancyScore: 0 |
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| Items | – Name: Title Label: Title Group: Ti Data: A Novel Confocal Scanning Protein-Protein Interaction Assay (PPI-CONA) Reveals Exceptional Selectivity and Specificity of CC0651, a Small Molecule Binding Enhancer of the Weak Interaction between the E2 Ubiquitin-Conjugating Enzyme CDC34A and Ubiquitin. – Name: Author Label: Authors Group: Au Data: <searchLink fieldCode="AU" term="%22Koszela+J%22">Koszela J</searchLink>; School of Molecular Biosciences, University of Glasgow, Glasgow G12 8QQ, U.K.<br /><searchLink fieldCode="AU" term="%22Pham+NT%22">Pham NT</searchLink>; School of Biological Sciences, University of Edinburgh, Edinburgh, Scotland EH9 3BF, U.K.; College of Medicine and Veterinary Medicine, Institute for Regeneration and Repair, University of Edinburgh, 4-5 Little France Drive, Edinburgh EH16 4UU, U.K.<br /><searchLink fieldCode="AU" term="%22Shave+S%22">Shave S</searchLink>; School of Biological Sciences, University of Edinburgh, Edinburgh, Scotland EH9 3BF, U.K.; Edinburgh Cancer Research, Cancer Research UK Scotland Centre, Institute of Genetics and Cancer, University of Edinburgh, Crewe Road South, Edinburgh EH4 2XR, U.K.<br /><searchLink fieldCode="AU" term="%22St-Cyr+D%22">St-Cyr D</searchLink>; X-Chem Inc., Montréal, Québec H4S 1Z9, Canada.; Institute for Research in Immunology and Cancer, University of Montreal, Montreal, Québec H3T 1J4, Canada.<br /><searchLink fieldCode="AU" term="%22Ceccarelli+DF%22">Ceccarelli DF</searchLink>; Centre for Systems Biology, Lunenfeld-Tanenbaum Research Institute, Mount Sinai Hospital, Toronto, Ontario M5G 1X5, Canada.<br /><searchLink fieldCode="AU" term="%22Orlicky+S%22">Orlicky S</searchLink>; Centre for Systems Biology, Lunenfeld-Tanenbaum Research Institute, Mount Sinai Hospital, Toronto, Ontario M5G 1X5, Canada.<br /><searchLink fieldCode="AU" term="%22Marinier+A%22">Marinier A</searchLink>; Institute for Research in Immunology and Cancer, University of Montreal, Montreal, Québec H3T 1J4, Canada.<br /><searchLink fieldCode="AU" term="%22Sicheri+F%22">Sicheri F</searchLink>; Centre for Systems Biology, Lunenfeld-Tanenbaum Research Institute, Mount Sinai Hospital, Toronto, Ontario M5G 1X5, Canada.<br /><searchLink fieldCode="AU" term="%22Tyers+M%22">Tyers M</searchLink>; Institute for Research in Immunology and Cancer, University of Montreal, Montreal, Québec H3T 1J4, Canada.; Program in Molecular Medicine, The Hospital for Sick Children, Toronto, Ontario M5G 0A4, Canada.<br /><searchLink fieldCode="AU" term="%22Auer+M%22">Auer M</searchLink>; School of Biological Sciences, University of Edinburgh, Edinburgh, Scotland EH9 3BF, U.K. – Name: TitleSource Label: Source Group: Src Data: <searchLink fieldCode="JN" term="%229010319%22">Bioconjugate chemistry</searchLink> [Bioconjug Chem] 2024 Sep 18; Vol. 35 (9), pp. 1441-1449. <i>Date of Electronic Publication: </i>2024 Aug 21. – Name: TypePub Label: Publication Type Group: TypPub Data: Journal Article; Research Support, Non-U.S. Gov't – Name: TitleSource Label: Journal Info Group: Src Data: <i>Publisher: </i><searchLink fieldCode="PB" term="%22American+Chemical+Society%22">American Chemical Society </searchLink><i>Country of Publication: </i>United States <i>NLM ID: </i>9010319 <i>Publication Model: </i>Print-Electronic <i>Cited Medium: </i>Internet <i>ISSN: </i>1520-4812 (Electronic) <i>Linking ISSN: </i><searchLink fieldCode="IS" term="%2210431802%22">10431802 </searchLink><i>NLM ISO Abbreviation: </i>Bioconjug Chem <i>Subsets: </i>MEDLINE |
| PLink | https://search.ebscohost.com/login.aspx?direct=true&site=eds-live&db=mdl&AN=39167708 |
| RecordInfo | BibRecord: BibEntity: Identifiers: – Type: doi Value: 10.1021/acs.bioconjchem.4c00345 Languages: – Code: eng Text: English PhysicalDescription: Pagination: StartPage: 1441 Titles: – TitleFull: A Novel Confocal Scanning Protein-Protein Interaction Assay (PPI-CONA) Reveals Exceptional Selectivity and Specificity of CC0651, a Small Molecule Binding Enhancer of the Weak Interaction between the E2 Ubiquitin-Conjugating Enzyme CDC34A and Ubiquitin. Type: main BibRelationships: HasContributorRelationships: – PersonEntity: Name: NameFull: Koszela J – PersonEntity: Name: NameFull: Pham NT – PersonEntity: Name: NameFull: Shave S – PersonEntity: Name: NameFull: St-Cyr D – PersonEntity: Name: NameFull: Ceccarelli DF – PersonEntity: Name: NameFull: Orlicky S – PersonEntity: Name: NameFull: Marinier A – PersonEntity: Name: NameFull: Sicheri F – PersonEntity: Name: NameFull: Tyers M – PersonEntity: Name: NameFull: Auer M IsPartOfRelationships: – BibEntity: Dates: – D: 18 M: 09 Text: 2024 Sep 18 Type: published Y: 2024 Identifiers: – Type: issn-electronic Value: 1520-4812 Numbering: – Type: volume Value: 35 – Type: issue Value: 9 Titles: – TitleFull: Bioconjugate chemistry Type: main |
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