Tumor editing suppresses innate and adaptive antitumor immunity and is reversed by inhibiting DNA methylation.

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Title: Tumor editing suppresses innate and adaptive antitumor immunity and is reversed by inhibiting DNA methylation.
Authors: Zhang Y; Program in Cellular and Molecular Medicine, Boston Children's Hospital, Boston, MA, USA. ying.zhang@pku.edu.cn.; Department of Pediatrics, Harvard Medical School, Boston, MA, USA. ying.zhang@pku.edu.cn.; Key Laboratory of Cell Proliferation and Differentiation of the Ministry of Education, School of Life Sciences, Peking University, Beijing, China. ying.zhang@pku.edu.cn.; Peking-Tsinghua Center for Life Sciences, Peking University, Beijing, China. ying.zhang@pku.edu.cn., Naderi Yeganeh P; Department of Pathology, Beth Israel Deaconess Medical Center, Boston, MA, USA.; Harvard Medical School, Boston, MA, USA., Zhang H; Program in Cellular and Molecular Medicine, Boston Children's Hospital, Boston, MA, USA.; Department of Pediatrics, Harvard Medical School, Boston, MA, USA., Wang SY; Department of Pediatrics, Harvard Medical School, Boston, MA, USA.; Division of Newborn Medicine, Boston Children's Hospital, Boston, MA, USA., Li Z; Program in Cellular and Molecular Medicine, Boston Children's Hospital, Boston, MA, USA.; Department of Pediatrics, Harvard Medical School, Boston, MA, USA.; Department of Immunology, University of Texas MD Anderson Cancer Center, Houston, TX, USA., Gu B; Program in Cellular and Molecular Medicine, Boston Children's Hospital, Boston, MA, USA.; Department of Pediatrics, Harvard Medical School, Boston, MA, USA., Lee DJ; Program in Cellular and Molecular Medicine, Boston Children's Hospital, Boston, MA, USA.; Department of Pediatrics, Harvard Medical School, Boston, MA, USA., Zhang Z; Program in Cellular and Molecular Medicine, Boston Children's Hospital, Boston, MA, USA.; Department of Pediatrics, Harvard Medical School, Boston, MA, USA.; Department of Immunology, University of Texas MD Anderson Cancer Center, Houston, TX, USA., Ploumakis A; Harvard Medical School, Boston, MA, USA.; Spatial Technologies Unit, Beth Israel Deaconess Medical Center, Boston, MA, USA., Shi M; Department of Biological Chemistry and Molecular Pharmacology, Harvard Medical School, Boston, MA, USA.; School of Life Science and Technology, Harbin Institute of Technology, Harbin, China., Wu H; Program in Cellular and Molecular Medicine, Boston Children's Hospital, Boston, MA, USA.; Department of Biological Chemistry and Molecular Pharmacology, Harvard Medical School, Boston, MA, USA., Greer EL; Department of Pediatrics, Harvard Medical School, Boston, MA, USA.; Division of Newborn Medicine, Boston Children's Hospital, Boston, MA, USA.; Departments of Pediatrics and Genetics, Washington University School of Medicine in St. Louis, St. Louis, MO, USA., Hide W; Department of Pathology, Beth Israel Deaconess Medical Center, Boston, MA, USA. whide@bidmc.harvard.edu.; Harvard Medical School, Boston, MA, USA. whide@bidmc.harvard.edu., Lieberman J; Program in Cellular and Molecular Medicine, Boston Children's Hospital, Boston, MA, USA. judy.lieberman@childrens.harvard.edu.; Department of Pediatrics, Harvard Medical School, Boston, MA, USA. judy.lieberman@childrens.harvard.edu.
Source: Nature immunology [Nat Immunol] 2024 Oct; Vol. 25 (10), pp. 1858-1870. Date of Electronic Publication: 2024 Aug 21.
Publication Type: Journal Article
Journal Info: Publisher: Nature America Inc Country of Publication: United States NLM ID: 100941354 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1529-2916 (Electronic) Linking ISSN: 15292908 NLM ISO Abbreviation: Nat Immunol Subsets: MEDLINE
Database: MEDLINE Ultimate
Description
ISSN:1529-2916
DOI:10.1038/s41590-024-01932-8