Intranasal delivery of small extracellular vesicles reduces the progress of amyotrophic lateral sclerosis and the overactivation of complement-coagulation cascade and NF-ĸB signaling in SOD1G93A mice.
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| Title: | Intranasal delivery of small extracellular vesicles reduces the progress of amyotrophic lateral sclerosis and the overactivation of complement-coagulation cascade and NF-ĸB signaling in SOD1G93A mice. |
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| Authors: | Zhou J; Department of Hand Surgery, The Second Hospital of Jilin University, Changchun, 130041, P. R. China., Li F; Key Laboratory of CNS Regeneration (Ministry of Education), Guangdong Key Laboratory of Non-human Primate Research, Guangdong-Hongkong-Macau CNS Regeneration Institute of Jinan University, Guangzhou, 510632, P. R. China., Jia B; Key Laboratory of CNS Regeneration (Ministry of Education), Guangdong Key Laboratory of Non-human Primate Research, Guangdong-Hongkong-Macau CNS Regeneration Institute of Jinan University, Guangzhou, 510632, P. R. China., Wu Z; Otorhinolaryngology Hospital, The First Affiliated Hospital, Sun Yat-sen University, Guangzhou, 510080, P. R. China.; Extracellular Vesicle Research and Clinical Translational Center, The First Affiliated Hospital, Sun Yat-sen University, Guangzhou, 510080, P. R. China., Huang Z; Key Laboratory of CNS Regeneration (Ministry of Education), Guangdong Key Laboratory of Non-human Primate Research, Guangdong-Hongkong-Macau CNS Regeneration Institute of Jinan University, Guangzhou, 510632, P. R. China., He M; Key Laboratory of CNS Regeneration (Ministry of Education), Guangdong Key Laboratory of Non-human Primate Research, Guangdong-Hongkong-Macau CNS Regeneration Institute of Jinan University, Guangzhou, 510632, P. R. China., Weng H; Key Laboratory of CNS Regeneration (Ministry of Education), Guangdong Key Laboratory of Non-human Primate Research, Guangdong-Hongkong-Macau CNS Regeneration Institute of Jinan University, Guangzhou, 510632, P. R. China., So KF; Key Laboratory of CNS Regeneration (Ministry of Education), Guangdong Key Laboratory of Non-human Primate Research, Guangdong-Hongkong-Macau CNS Regeneration Institute of Jinan University, Guangzhou, 510632, P. R. China.; Co-innovation Center of Neuroregeneration, Nantong University, Nantong, Jiangsu, P. R. China.; Neuroscience and Neurorehabilitation Institute, University of Health and Rehabilitation Sciences, Qingdao, Shandong, 266071, P. R. China.; Department of Neurology and Stroke Center, The First Affiliated Hospital & Clinical, Neuroscience Institute of Jinan University, Guangzhou, 510632, P. R. China.; Center for Exercise and Brain Science, School of Psychology, Shanghai University of Sport, Shanghai, 200438, P. R. China., Qu W; Department of Hand Surgery, The Second Hospital of Jilin University, Changchun, 130041, P. R. China. quwenrui@jlu.edu.cn., Fu QL; Otorhinolaryngology Hospital, The First Affiliated Hospital, Sun Yat-sen University, Guangzhou, 510080, P. R. China. fuqingl@mail.sysu.edu.cn.; Extracellular Vesicle Research and Clinical Translational Center, The First Affiliated Hospital, Sun Yat-sen University, Guangzhou, 510080, P. R. China. fuqingl@mail.sysu.edu.cn.; Otorhinolaryngology Hospital, Extracellular Vesicle Research and Clinical Translational Center, The First Affiliated Hospital, Sun Yat-sen University, Zhongshan Road II 58, Guangzhou, 510080, P. R. China. fuqingl@mail.sysu.edu.cn., Zhou L; Key Laboratory of CNS Regeneration (Ministry of Education), Guangdong Key Laboratory of Non-human Primate Research, Guangdong-Hongkong-Macau CNS Regeneration Institute of Jinan University, Guangzhou, 510632, P. R. China. tlibingzh@jnu.edu.cn.; Co-innovation Center of Neuroregeneration, Nantong University, Nantong, Jiangsu, P. R. China. tlibingzh@jnu.edu.cn.; Neuroscience and Neurorehabilitation Institute, University of Health and Rehabilitation Sciences, Qingdao, Shandong, 266071, P. R. China. tlibingzh@jnu.edu.cn.; Department of Neurology and Stroke Center, The First Affiliated Hospital & Clinical, Neuroscience Institute of Jinan University, Guangzhou, 510632, P. R. China. tlibingzh@jnu.edu.cn.; Center for Exercise and Brain Science, School of Psychology, Shanghai University of Sport, Shanghai, 200438, P. R. China. tlibingzh@jnu.edu.cn.; Guangdong-Hongkong-Macau CNS Regeneration Institute, Jinan University, Huangpu Avenue West 601, Guangzhou, 510632, P. R. China. tlibingzh@jnu.edu.cn. |
| Source: | Journal of nanobiotechnology [J Nanobiotechnology] 2024 Aug 22; Vol. 22 (1), pp. 503. Date of Electronic Publication: 2024 Aug 22. |
| Publication Type: | Journal Article |
| Journal Info: | Publisher: BioMed Central Country of Publication: England NLM ID: 101152208 Publication Model: Electronic Cited Medium: Internet ISSN: 1477-3155 (Electronic) Linking ISSN: 14773155 NLM ISO Abbreviation: J Nanobiotechnology Subsets: MEDLINE |
| Database: | MEDLINE Ultimate |
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| ISSN: | 1477-3155 |
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| DOI: | 10.1186/s12951-024-02764-2 |
