Losartan alters osteoblast differentiation and increases bone mass through inhibition of TGFB signalling in vitro and in an OIM mouse model.

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Title: Losartan alters osteoblast differentiation and increases bone mass through inhibition of TGFB signalling in vitro and in an OIM mouse model.
Authors: Morita M; Mellanby Centre for Musculoskeletal Research and Division of Clinical Medicine, University of Sheffield, Beech Hill Road, Sheffield, UK., Arshad F; Mellanby Centre for Musculoskeletal Research and Division of Clinical Medicine, University of Sheffield, Beech Hill Road, Sheffield, UK., Quayle LA; Department of Computing, Sheffield Hallam University, Cantor Building, Arundel Street, Sheffield, UK., George CN; Mellanby Centre for Musculoskeletal Research and Division of Clinical Medicine, University of Sheffield, Beech Hill Road, Sheffield, UK., Lefley DV; Mellanby Centre for Musculoskeletal Research and Division of Clinical Medicine, University of Sheffield, Beech Hill Road, Sheffield, UK., Kalajzic I; Reconstructive Sciences, UConn Health, Farmington, CT. USA., Balsubramanian M; Mellanby Centre for Musculoskeletal Research and Division of Clinical Medicine, University of Sheffield, Beech Hill Road, Sheffield, UK.; Highly specialised Osteogenesis Imparfecta Service, Sheffield Children's NHS Foundation Trust, Sheffield, UK., Cebe T; INSIGNIO Institute for in silico Medicine and the Kroto Research Institute, Department of Materials Science and Engineering, University of Sheffield, Sheffield, UK., Reilly G; INSIGNIO Institute for in silico Medicine and the Kroto Research Institute, Department of Materials Science and Engineering, University of Sheffield, Sheffield, UK., Bishop NJ; Mellanby Centre for Musculoskeletal Research and Division of Clinical Medicine, University of Sheffield, Beech Hill Road, Sheffield, UK.; Highly specialised Osteogenesis Imparfecta Service, Sheffield Children's NHS Foundation Trust, Sheffield, UK., Ottewell PD; Mellanby Centre for Musculoskeletal Research and Division of Clinical Medicine, University of Sheffield, Beech Hill Road, Sheffield, UK.
Source: Bone reports [Bone Rep] 2024 Jul 25; Vol. 22, pp. 101795. Date of Electronic Publication: 2024 Jul 25 (Print Publication: 2024).
Publication Type: Journal Article
Journal Info: Publisher: Elsevier Inc Country of Publication: United States NLM ID: 101646176 Publication Model: eCollection Cited Medium: Print ISSN: 2352-1872 (Print) Linking ISSN: 23521872 NLM ISO Abbreviation: Bone Rep Subsets: PubMed not MEDLINE
Database: MEDLINE Ultimate
Description
ISSN:2352-1872
DOI:10.1016/j.bonr.2024.101795